Patents Examined by Scott David Priebe
  • Patent number: 5580734
    Abstract: Materials and methods for homologous-recombination screening of DNA libraries constructed in a eukaryotic host and methods for homologous-recombination chromosome walking for isolating overlapping DNA sequences for building an extended physical map of a chromosomal region.
    Type: Grant
    Filed: September 6, 1994
    Date of Patent: December 3, 1996
    Assignee: Transkaryotic Therapies, Inc.
    Inventors: Douglas A. Treco, Allan M. Miller
  • Patent number: 5580958
    Abstract: The invention provides a purified polypeptide having substantially the same amino acid sequence and activity as the protein having the amino acid sequence of FIG. 1 , or a characteristic fragment thereof. The polypeptide is a transcriptional activator. Nucleic acids encoding the polypeptide and uses are also provided.
    Type: Grant
    Filed: June 28, 1994
    Date of Patent: December 3, 1996
    Assignee: La Jolla Cancer Research Foundation
    Inventors: Richard A. Maki, Michael J. Klemsz, Scott R. McKercher, Antonio Celada
  • Patent number: 5561043
    Abstract: The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.
    Type: Grant
    Filed: January 31, 1994
    Date of Patent: October 1, 1996
    Assignee: Trustees of Boston University
    Inventors: Charles R. Cantor, Christof M. Niemeyer, Cassandra L. Smith, Takeshi Sano, Donald J. Hnatowich, Mary Rusckowski
  • Patent number: 5556752
    Abstract: Libraries of unimolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific interactions between the double-stranded oligonucleotides, and peptides, proteins, drugs and RNA. In a related aspect, the present invention provides libraries of conformationally restricted probes on a solid support. The probes are restricted in their movement and flexibility using double-stranded oligonucleotides as scaffolding. The probes are also useful in various screening procedures associated with drug discovery and diagnosis. The present invention further provides methods for the preparation and screening of the above libraries.
    Type: Grant
    Filed: October 24, 1994
    Date of Patent: September 17, 1996
    Assignee: Affymetrix, Inc.
    Inventors: David J. Lockhart, Dirk Vetter, Martin Diggelmann