Abstract: The present invention relates to a novel human epidermal growth factor (hEGF)-trigger factor (TF) fusion protein and a use thereof. More particularly, the human epidermal growth factor (hEGF)-trigger factor (TF) fusion protein of the present invention has fused therein: a signal peptide of a Bacillus subtilis-derived xylanase; a human epidermal growth factor (hEGF); and an Escherichia coli-derived trigger factor (TF). Therefore, the present invention not only enhances the water solubility and expression rate of a target protein, but also notably enhances useful effects such as the effects of increasing skin cell growth and healing a wound, and thus may be widely used in various industries as an active ingredient for a functional cosmetic composition and a pharmaceutical composition.
Type:
Grant
Filed:
November 6, 2020
Date of Patent:
July 14, 2026
Assignee:
KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY
Inventors:
Chul Hong Oh, Yoon Hyeok Kang, Eun Young Jo, Do Hyung Kang, Young Deuk Lee, Duck Hee Jang, Ye Hui Gang, Tae Yang Eom, Sachithra Amarin Hettiarachchi
Abstract: The present disclosure provides a Paenibacillus mucilaginosus LT1906 and use thereof, and a microorganism-activated circulating fluidized bed (CFB) fly ash-based cementitious material and a preparation method and use thereof, belonging to the technical field of cementitious materials. The Paenibacillus mucilaginosus LT1906 has a deposit number of CGMCC No. 21337. The strain is capable of dissolving silicate minerals and aluminosilicate minerals in the CFB fly ash to increase dissolution of active SiO2. The strain is used for activating the CFB fly ash-based cementitious material, to ameliorate a large water demand and a low early strength of the cementitious material, thereby improving comprehensive utilization of the CFB fly ash in the field of building materials.