Abstract: A guide wire comprising an elongate, flexible core having a proximal region, a proximal end, a distal region, and a distal end; and a plurality of wire strands wrapped helically parallel to one another and disposed on at least a portion of the distal region of the core.

Abstract: An embodiment of the invention includes (a) modeling a first internal force applied to a model of a user's joint based on a first external force externally applied to the joint at a first position; (b) modeling a second internal force applied to the model based on a second external force externally applied to the joint at a second position unequal to the first position; (c) comparing the first and second modeled internal forces; and (d) simulating the user based on the comparison. Other embodiments are described herein.

Abstract: An apparatus and method are adapted for characterizing human tissue type. A plurality of inflatable bladders enable the application of kinetic energy to the human tissue. Collected data responsive to the applied kinetic energy differentiates between different tissue types and patient loading. The data can be routed via a network to a remote location.

Abstract: An objective lens system for an optical biopsy device has a lens that comprises a first part configured for viewing at a first magnification, and a second part configured for viewing at a second magnification. The second magnification is substantially different from the first magnification. The first magnification enables viewing a larger area of a target and the second magnification enables viewing the target at a cellular level with high sensitivity and specificity. Combining viewing at two different magnifications in a single objective lens results in a compact optical biopsy device.

Abstract: A fluid handling device includes a receiving container with a piston arranged therein in a displaceable manner, such that the volume of a fluid receiving reservoir may be changed by a displacement of the piston. In addition, the fluid handling device includes an actuation mechanism configured to displace a carrier bearing upon actuation of the former. Finally, the fluid handling device includes a spring mechanism configured to transfer a force from the carrier bearing to the piston so as to effect, in response to displacement of the carrier bearing in a first direction, a displacement of the piston within the receiving container such that a volume of the fluid reservoir is increased.

Abstract: Posture-responsive therapy is delivered by the medical system based on posture state input from only one of multiple posture sensors at any given time. An example implantable medical system includes a first posture sensor and a second sensor. A processor controls therapy delivery to the patient based on at least one of a patient posture state or a patient activity level determined based on input from only one of the first or second posture sensors. In some examples, one of multiple posture sensors of an implantable posture-responsive medical system is used to automatically reorient another posture sensor (of the system), which has become disoriented. The disoriented posture sensor may be automatically reoriented for one or more posture states at a time.

Abstract: An inertial sensor based surgical navigation system for knee replacement surgery is disclosed. Inertial sensors composed of six-degree-of-freedom inertial chips, whose measurements are processed through a series of integration, quaternion, and kalman filter algorithms, are used to track the position and orientation of bones and surgical instruments. The system registers anatomically significant geometry, calculates joint centers and the mechanical axis of the knee, develops a visualization of the lower extremity that moves in real time, assists in the intra-operative planning of surgical cuts, determines the optimal cutting planes for cut guides and the optimal prosthesis position and orientation, and finally navigates the cut guides and the prosthesis to their optimal positions and orientations using a graphical user interface.

Abstract: A guide block configured to be inserted into an opening of a grid-like breast receiving pressure plate to guide a tissue-removing device to a desired location within a patient's breast. The guide block includes a body having a body length between a proximal face and a distal face. The body length has a plurality of sides configured in a polygonal arrangement that corresponds to a shape of the opening in the grid-like breast receiving pressure plate. Each of a first guide passageway and a second guide passageway extends within the polygonal arrangement. The second guide passageway is coextensive with and configured to overlap the first guide passageway in a direction of extent of the plurality of sides to form a longitudinal opening between the first guide passageway and the second guide passageway that extends from the proximal face to the distal face.

Abstract: Systems and related methods for measuring pelvic organ prolapse are disclosed. A plurality of positioning devices, such as RFID tags, ultrasound reflectors or magnetic field sensors, which may be active or passive, and which are preferably disposable, are set at predetermined positions within the patient and their relative positions recorded with one or more corresponding external receiving devices fixed to the patient while the patient is in a relaxed state. The patient is then instructed to perform an action (such as a valsalva maneuver) that causes the positioning devices to move and their movement relative to their initial recorded positions is measured.

Abstract: The present invention relates to a device and method for easy collection, dilution, mixing and dispensing of a liquid specimen in a self-contained system. The present invention can be used in combination with numerous testing means for performing chemical, biochemical or biomedical qualitative or quantitative assays in the field of both clinical and hygiene testing.

Abstract: Systems and methods deform the surface of the material with a probe, such as a mechanical device or a gas/liquid jet, while optically recording in detail the three-dimensional (3D) topography of the resulting surface deformation. The probe effectively applies a forcing function to the material, the attributes of which are known by performing calibrations prior to use or by direct measurement while it is applied. The topography is effectively the system output that is measured as indicative of the underlying mechanical properties of the material. In one application, systems and methods that apply a pressure in-vivo to human tissue and analyze a three-dimensional topography of the resulting surface deformation to identify localized inhomogeneities and anomalies in the human tissue.

Abstract: Methods and apparatus collecting blood from patients and managing blood donations are provided, which may include any number of features. One feature is a blood collection device configured to collect blood from a patient and periodically transmit blood collection data from the device to a control system. Another feature is a system and method for updating firmware on a plurality of blood collection devices. In one embodiment, a software interface with a blood collection control can be used to specify a blood collection protocol, and the blood collection protocol can be then transmitted to one or more blood collection devices.

Abstract: A balloon catheter having a mesh affixed thereto. The mesh is formed having members extending longitudinally and circumferentially about the balloon into columns and rows respectively. Each member of the mesh has a resistance or impedance that changes as the member is deformed such that, when the member comprises a length (L) a measured resistance or impedance will be different than when the member comprise a length (L1) where L1 is greater than L.

Abstract: Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.

Abstract: Provided are devices and methods suitable for immobilizing tissue and for use in non-invasive methods of assessing lower urinary tract symptoms as well as in surgical application.

Abstract: In an automated methodology for carrying out in vivo cell patch clamping, a cell patch clamping device is automatically moved into position and targeted to a neuron. Neuron contact is determined by analyzing the temporal series of measured resistance levels at the cell patch clamping device as it is moved. The difference between successive resistance levels is computed and compared to a threshold, which must be exceeded for a minimum number of computations before neuron contact is assumed. Pneumatic control methods are used to achieve gigaseal formation and cell break-in, leading to whole-cell patch clamp formation. An automated robotic system capable of performing this methodology automatically performs patch clamping in vivo, automatically detecting cells by analyzing the temporal sequence of electrode impedance changes.

Abstract: This invention provides a novel nostril gauge system and methods for using the same, which allows the practitioner to measure the size of deformed nostrils resulting from any cause such as from a cleft lip and/or cleft palate, a traumatic injury, an infectious process, a prior surgical intervention, etc. The device allows for the expeditious and accurate measurement of the size/caliber of normal and deformed nostrils before any type of nasal reconstruction intended to correct asymmetric nostril openings (nares). The gauge includes a series of measured and accurately sized gauge steps that are readily used and result in a more precise nostril sizing. The gauge includes a plurality of spines, each having steps thereon correlating to different circumferential sizes. The gauge system is provided with printed size indicia that refers to each gauge step and facilitates the measuring process. In illustrative embodiments, the gauge body defines a loop with a plurality of gauge spines, arranged around its perimeter.

Abstract: A medical instrument with a handle arranged at the proximal end, with a shank arranged on the handle, and with a tool arranged at the distal end of the shank. The medical instrument can provide several functionalities, for example the rotation about the longitudinal axis of the medical instrument, the pivoting of the tool relative to the longitudinal axis of the medical instrument and/or the actuation of the tool, for example the opening or closing of scissors. Some of these functionalities are activated with the aid of a single common actuation element. By moving the actuation element between several switch positions, different functionalities are selected, and these are activated, e.g. by rotation of the actuation element.

Abstract: This invention relates to a system for monitoring the position of a measuring unit when placed on a person, especially on the chest of a person, the system comprising a drive unit generating a magnetic field oscillating at a predetermined frequency adapted to be positioned on the opposite side of the person, e.g. chest to back dimensions, and the measuring unit being adapted to measure the magnetic field strength, the system including calculating means for calculating the distance between the measuring unit and the drive unit.

Abstract: One embodiment of a multifunction aspiration biopsy device includes a hub having a chamber for receiving a collected specimen, a vacuum source in communication with the hub chamber, a needle detachable from the hub and having an outlet in communication with the hub chamber, and a cover extending over a portion of the needle outlet for directing a specimen collected through the needle into the hub chamber in a direction that differs from a longitudinal axis of the needle. The hub chamber with collected specimen may be separated from the vacuum source and the needle and the specimen may be triaged within the hub chamber. Various embodiments of a collection container for receiving used needles are also disclosed.