Abstract: Benzoic acid derivatives of the formula
where
X is oxygen, sulfur, —NH, —NR1, —N—CN, —N—OR1 or —N—NO2;
Y is a single bond, —C═C—, or —NH;
R1 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocyclo, or (heterocyclo)alkyl; and
R2 is aryl or heterocyclo. The compounds of formula I are useful in the treatment of arrhythmia.
Type:
Grant
Filed:
September 25, 2002
Date of Patent:
September 23, 2003
Assignee:
Bristol-Myers Squibb Company
Inventors:
John Lloyd, George C. Rovnyak, Philip D. Stein, Saleem Ahmad, Karnail S. Atwal, Thomas J. Caulfield, Michael A. Poss