Patents Examined by Shaojia A. Jiang
  • Patent number: 10538597
    Abstract: The invention concerns a process for the manufacture of an acylated polymer composition comprising amylose and/or amylopectin, comprising a pre-treatment step in the presence of an acid, a salt and a polycarboxylic acid, subsequent acylation and, preferably, a post-treatment step with an acid. The products obtained are useful as additives in inks, varnishes, lacquers, coatings, thickeners, adhesives or binders.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: January 21, 2020
    Assignee: Rhodia Acetow GmbH
    Inventors: Jana Lubkoll, Armin Stein
  • Patent number: 10508155
    Abstract: Provided is a method for efficiently and continuously producing a cellulose ether containing a reduced amount of indissoluble component. Specifically, the method includes a contact step of bringing pulp into contact with an alkali metal hydroxide solution in the presence of a heat removal solvent to obtain alkali cellulose; a reaction step of subjecting the alkali cellulose to a reaction with an etherifying agent; a partial condensation step, after completion of the reaction, of partially condensing a gas present in a reaction vessel used for the reaction to separate the gas into gas and liquid components for returning some or all of the gas component to the contact step for reuse as some or all of the heat removal solvent; and a step of incinerating the liquid component and, when all of the gas component is not returned to the contact step, the remainder of the gas component.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: December 17, 2019
    Inventors: Atsushi Yamamoto, Shinichi Kurotani, Atsuhiko Yonemochi, Mitsuo Narita
  • Patent number: 10508172
    Abstract: The present invention relates to binder compositions with an improved amine component, and a method of manufacturing a collection of matter bound by said binder compositions.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: December 17, 2019
    Assignees: Knauf Insulation, Inc., Knauf Insulation SPRL
    Inventor: Benedicte Pacorel
  • Patent number: 10478447
    Abstract: The disclosure provides an oral antiviral supplement composition comprising a lysine, an ascorbic compound, a flavonoid glycoside, a threonine, and a pyridoxine. The disclosure also provides a method of reducing viral replication in a cell comprising treating a virus-infected cell with a composition of the disclosure. The disclosure further provides a method for the treatment and prophylaxis of a viral infection in a patient comprising administering a composition of the disclosure.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: November 19, 2019
    Assignee: Vymedic, LLC
    Inventors: Kenneth E. Phillips, Cynthia A. Winning
  • Patent number: 10479840
    Abstract: A resistant dextrin and a method for preparing the same. In the resistant dextrin, molar content of DP1 is smaller than or equal to 1%, molar content of DP2 is smaller than or equal to 4.5%, molar content of DP3 is smaller than or equal to 7.0%, an average degree of polymerization is 6-12, a pH value is 3.0-6.0, and molar content of dietary fibers is greater than or equal to 85%. The present invention further relates to a method for preparing the resistant dextrin. Since the present invention uses starch as the raw material and divides dextrinization reaction into two stages for the first time, the degree of polymerization of the polymerization reaction is reliably guaranteed, the number of caused side reactions is decreased at the same time and the difficulty in subsequent purification treatment is greatly decreased.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: November 19, 2019
    Inventors: Guangpeng Dou, Zhaobo Gan, Fanghua Li, Xianbao Shao, Tengteng Yang, Qian Du, Mingzhan Zhang, Xingjing Zhang
  • Patent number: 10471080
    Abstract: Maternal diabetes suppresses autophagy in neuroepithelial cells of the developing neural tube which leads to neural tube defect formation. Trehalose treatment reversed autophagy impairment and prevented neural tube defects in diabetic pregnancies. Trehalose resolved homeostatic imbalance by correcting mitochondrial defects, dysfunctional proteins, ER stress, apoptosis, and delayed neurogenesis in the neural tubes exposed to hyperglycemia. Methods of using trehalose as an intervention against hyperglycemia-induced neural tube defects are provided herein.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: November 12, 2019
    Inventors: Peixin Yang, E. Albert Reece
  • Patent number: 10471082
    Abstract: Methods of treating or preventing a Flavivirus infection in a subject are provided. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus protease inhibitor. These methods are useful in treating and/or preventing Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus. Methods of inhibiting a Flavivirus protease in a cell are also provided.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: November 12, 2019
    Assignee: Georgetown University
    Inventors: Radhakrishnan Padmanabhan, Tadahisa Teramoto, Mark Manzano
  • Patent number: 10449249
    Abstract: Objective of the present invention is to provide polysaccharides which modulate immune response, and which can be used as ingredients in edible products or pharmaceutical compositions. The present invention provides such polysaccharides obtained from the species Camellia sinensis, which comprise a rhamnogalacturonan-I core, and wherein the molar ratio of galacturonyl acid residues to rhamnosyl residues in the backbone of the polysaccharide is close to 1:1. The present invention also provides edible products or pharmaceutical compositions containing such polysaccharides, in order to modulate immune response.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: October 22, 2019
    Assignee: NUTRILEADS B.V.
    Inventors: Ruud Albers, Jari Helin, Werner Klaffke, Jean Hypolites Koek, Petronella Anna Kreijveld, Jari Natunen, Erwin Werner Tareilus, Richardus Paulus Anton Oranje
  • Patent number: 10442870
    Abstract: Provided is a novel cellulose derivative having excellent water resistance. This is a cellulose acylate oxoalkanoate which is a cellulose derivative corresponding to cellulose, except with substituents replacing part or all of hydrogen atoms in the hydroxy groups of the cellulose. The substituents includes a group represented by General Formula (1) and a group represented by General Formula (2). The cellulose acylate oxoalkanoate has a degree x of substitution with the group represented by General Formula (1), a degree y of substitution with the group represented by General Formula (2), and a degree z of unsubstitution, where x, y, and z meet conditions specified by Expressions (A), (B), and (C): 0.1?x?2.99??(A) 0.01?y?2.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: October 15, 2019
    Inventors: Tomohiro Hashizume, Shizuka Ukita, Shu Shimamoto, Toshikazu Nakamura
  • Patent number: 10442832
    Abstract: Novel processes for making the N-pyrrazole substituted 2-adenosine derivative regadenoson and a novel polymorph thereof. The novel polymorph of regadenoson designated form H and drug substances and pharmaceutical compositions including the novel polymorph H are disclosed.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: October 15, 2019
    Assignee: APICORE US LLC
    Inventors: Ravishanker Kovi, Ashish Naik, Piyush Fadadu, Jayaraman Kannapan
  • Patent number: 10435523
    Abstract: The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: October 8, 2019
    Inventors: Susan P. James, Min Zhang, Guy Beauregard, Rachael Kurkowski Oldinski
  • Patent number: 10435428
    Abstract: The invention provides compounds which are prodrugs of a JAK inhibitor agent for the targeted delivery of the JAK inhibitor to the gastrointestinal tract of a mammal. The invention also provides pharmaceutical compositions comprising the compounds, methods of using the compounds to treat gastrointestinal inflammatory diseases, and processes and intermediates useful for preparing the compounds.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: October 8, 2019
    Inventors: Ryan Hudson, Daniel D. Long, Donna A. A. Wilton, Mandy Loo, Patrick J. Brassil
  • Patent number: 10426791
    Abstract: The present invention relates to the field of prebiotics. Provided are uses for compositions comprising synergistically effective amounts of polyfructose and galactooligosaccharides (GOS).
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: October 1, 2019
    Assignee: N.V. Nutricia
    Inventors: Gelske Speelmans, Maria Johanna Adriana Petronella Govers, Jan Knol, Eric Alexander Franciscus Van Tol
  • Patent number: 10420786
    Abstract: The invention related to a composition for use in cardioplegia, said composition comprising (i) esmolol; and (ii) adenosine, wherein in use the concentration of said esmolol is in the range 0.3-1.5 mM, and wherein in use the concentration of said adenosine is in the range 0.1-1.5 mM. The invention also relates to methods of making and using such compositions.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: September 24, 2019
    Assignee: AOP ORPHAN IP AG
    Inventors: Hazem B. Fallouh, Jonathan C. Kentish, David J. Chambers
  • Patent number: 10420793
    Abstract: Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: September 24, 2019
    Assignee: Galectin Therapeutics, Inc.
    Inventors: Eliezer Zomer, Peter G. Traber, Anatole A. Klyosov, Elena Chekhova
  • Patent number: 10413566
    Abstract: A method of treatment includes agitating a thixotropic oxidized cellulose solution; administering the agitated thixotropic oxidized cellulose solution to a target tissue site; and allowing the agitated thixotropic oxidized cellulose solution to gel at the target tissue site.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: September 17, 2019
    Assignee: Covidien LP
    Inventors: Rachit Ohri, Phillip D. Blaskovich
  • Patent number: 10407830
    Abstract: A surfactant treated bleached softwood kraft pulp fiber, useful as a starting material in the production of cellulose derivatives including cellulose ether, cellulose esters and viscose, is disclosed. Methods for making the kraft pulp fiber and products made from it are also described.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: September 10, 2019
    Assignee: GP Cellulose GmbH
    Inventors: Arthur J. Nonni, Charles E. Courchene, Christopher M. Slone, Philip R. Campbell, Steven C. Dowdle, Joel M. Engle
  • Patent number: 10407515
    Abstract: A method for the qualification and selection of manufacturing processes, raw materials, intermediates and batch production of pentosan polysulfate based on the identification of acetylated monosaccharide units, including units of xylose substituted with 4-O-methyl-glucuronic which also lead the acetyl group, as structural characterizing units, is disclosed.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: September 10, 2019
    Assignee: CHEMI S.P.A.
    Inventors: Lorenzo De Ferra, Annamaria Naggi, Maurizio Zenoni, Barbara Pinto
  • Patent number: 10406243
    Abstract: A medicinal composition for diseases caused by dyslipidemia and/or autophagy dysfunction, etc., said medicinal composition comprising polyrotaxane that carries bulky substituents introduced, via intracellularly degradable bonds, into both ends of a linear molecule penetrating through plural cyclic molecules.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: September 10, 2019
    Assignee: National University Corporation Tokyo Medical and Dental University
    Inventors: Atsushi Tamura, Nobuhiko Yui
  • Patent number: 10392420
    Abstract: The present disclosure relates generally to methods of preparing glycoconjugates containing a saccharide conjugated to a carrier protein by use of stable nitroxyl radical related agent/oxidant as an oxidizing agent, to immunogenic compositions comprising such glycoconjugates, and to methods for the use of such glycoconjugates and immunogenic compositions.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: August 27, 2019
    Assignee: Pfizer Inc.
    Inventors: Mingming Han, Rajesh Kumar Kainthan, Jin-Hwan Kim, Avvari Krishna Prasad