Patents Examined by Shaojia A. Jiang
  • Patent number: 11013733
    Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: May 25, 2021
    Assignee: FORMA Therapeutics, Inc.
    Inventors: Susan Ashwell, Blythe Thomson, Patrick F. Kelly, Alan Collis, Jeff Davis, Duncan Walker, Wei Lu
  • Patent number: 11014952
    Abstract: The present invention provides a stable synthetic saccharide of Hib polyribosylribitol-phosphate (PRP) derivative and conjugate thereof. Said saccharide, said conjugate and pharmaceutical compositions thereof are hydrolysis-resistant, long-term stable and useful for the prevention and/or treatment of diseases associated with Haemophilus influenzae, and more specifically of diseases associated with Haemophilus influenzae type b, preferably diseases selected from meningitis, pneumonia, and epiglotitis. They have general formula (I): wherein A is formula (II) or formula (III); B is formula (IV); C is formula (V); D is formula (VI); E is formula (VII); F is formula (VIII) or formula (IX).
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: May 25, 2021
    Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Vaxxilon AG
    Inventors: Peter H. Seeberger, Claney Lebev Pereira
  • Patent number: 11014993
    Abstract: The present application relates to cellulose nanocrystals and other anionic carbohydrates and methods of preparation thereof. Specifically, in certain embodiments, the cellulose nanocrystals are modified using ion exchange technology to yield thermally stable or task-specific, dispersible cellulose nanocrystals.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: May 25, 2021
    Assignee: AMERICAN UNIVERSITY
    Inventor: Douglas Fox
  • Patent number: 11008356
    Abstract: The invention relates to lipochitooligosaccharides obtainable from arbuscular mycorrhizal fungi, and which are useful for stimulating arbuscular mycorrhizal symbiosis, and lateral root formation.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: May 18, 2021
    Assignees: Institut National de Recherche Pour l'Agriculture, l'Alimentation et Environnement, Centre National de la Recherche Scientifique, Universite Paul Sabatier
    Inventors: Jean Denarie, Fabienne Maillet, Verena Poinsot, Olivier Andre, Guillaume Becard, Monique Gueunier, Laurence Cromer, Alexandra Haouy, Delphine Giraudet
  • Patent number: 11007271
    Abstract: Provided herein is a conjugate comprising two residues of structurally and/or mechanistically different anticancer bioactive agents, coupled to one another by a biocleavable linking moiety, as well as methods of treating cancer using the same and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: May 18, 2021
    Assignee: Ariel Scientific Innovations Ltd.
    Inventors: Gary Gellerman, Yosi Gilad, Helena Tuchinsky
  • Patent number: 11000512
    Abstract: The present invention refers to compounds of formula I or II endowed with DDX3 inhibitory activity, relative pharmaceutical compositions and their use as antihyperproliferative agents. (I) or (II).
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: May 11, 2021
    Assignee: AZIENDA OSPEDALIERA UNIVERSITARIA SENESE
    Inventors: Annalaura Brai, Maurizio Botta, Cristina Tintori, Giovanni Maga
  • Patent number: 11000535
    Abstract: A composition for inhibiting a liver tumor in an organism is disclosed. The composition includes an activator being 1,2,3,4,6-penta-O-galloyl-Beta-D-glucopyranoside (PGG), wherein PGG is extracted from at least one of Paeonia lactiflora Pall. and Galla Chinesis.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: May 11, 2021
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yi-Ming Chen, Chia-Hung Yen, Chung-Kuang Lu
  • Patent number: 10987369
    Abstract: A Pdia4 inhibitor for use in preventing, alleviating and/or treating diabetes and/or diabetes-related complications in a subject in need thereof is disclosed, wherein the Pdia4 inhibitor does not comprise cytopiloyene. A Pdia4 inhibitor and one other anti-diabetic agent for use in combination therapy in preventing, alleviating, treating diabetes and diabetes-related complications, and/or reversing diabetes in a subject in need thereof is also disclosed, wherein the Pdia4 inhibitors for use in combination therapy may comprise cytopiloyene. Also disclosed are methods for diagnosing, treating and monitoring diabetes, and methods of screening for a Pdia4 inhibitor and/or an anti-diabetic agent.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: April 27, 2021
    Assignee: ACADEMIA SINICA
    Inventors: Wen-Chin Yang, Lee-Tian Chang
  • Patent number: 10982012
    Abstract: A process for dissolving modified cellulose is disclosed. The process includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: April 20, 2021
    Assignee: Covidien LP
    Inventors: Valentino J. Tramontano, Joshua Kennedy, Sajida Farooqi, Phillip D. Blaskovich, Rachit Ohri, Daniel S. Costa
  • Patent number: 10981135
    Abstract: The invention relates to a method for treating a nanofibrillar cellulose hydrogel, wherein the method comprises the steps of: providing a nanofibrillar cellulose hydrogel, wherein the nanofibrillar cellulose is oxidized nanofibrillar cellulose, wherein the oxidation has been carried out through N-oxyl mediated catalytic oxidation of cellulose-based raw material, and has at most 50 ?mol of aldehyde groups per gram of dry nanofibrillar cellulose; and subjecting the nanofibrillar cellulose hydrogel to a heat treatment.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: April 20, 2021
    Assignee: UPM-KYMMENE CORPORATION
    Inventor: Isko Kajanto
  • Patent number: 10982009
    Abstract: To provide a cellulose derivative excellent in thermoplasticity, water resistance and strength (elastic modulus, impact strength), a cellulose derivative, which is obtained by introducing a short-chain organic group (acetyl group), a medium-chain organic group having 3 to 5 carbon atoms and a long-chain organic group having 6 to 30 carbon atoms at the following substitution degrees DSs into a cellulose, is used: Short-chain organic group: 0.7?DSSH?1.5; Medium-chain organic group: 0.5?DSME?2.0; Long-chain organic group: 0.1?DSLO<0.5; and 2.4?DSSH+DSME+DSLO?3.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: April 20, 2021
    Assignee: NEC CORPORATION
    Inventors: Midori Shimura, Shukichi Tanaka, Kiyohiko Toyama, Masatoshi Iji
  • Patent number: 10968284
    Abstract: The present invention is a multilayered composite comprising porous metal oxide particles that are covalently bonded by way of inorganic ether groups to one or more sites of a first polyhydroxyl-functionalized polymer. This first polymer is in turn covalently bonded by way of inorganic ether groups to one or more sites of a second polyhydroxyl-functionalized polymer. The multilayered composites can be prepared by contacting porous inorganic-oxide particles with a sufficient amount of OH-reactive crosslinking agent to form metal oxide particles imbibed with the crosslinking agent, and then contacting the inorganic-oxide particles with a solution of polyhydroxyl-functionalized polymer under reactive conditions.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: April 6, 2021
    Assignees: The Regents of the University of California, Dow Global Technologies LLC, Rohm and Haas Company
    Inventors: Joseph Jankolovits, Alexander S. Katz, Oz M. Gazit, James C. Bohling, John A. Roper, III
  • Patent number: 10968283
    Abstract: A method for producing functionalized nanocrystalline cellulose, the method comprising the steps of providing cellulose, mixing said cellulose with a peroxide, thereby producing a reaction mixture, and heating the reaction mixture, and/or exposing the reaction mixture to UV radiation is provided. Functionalized nanocrystalline cellulose produced by this method is also provided.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: April 6, 2021
    Assignee: Anomera Inc.
    Inventors: Mark P. Andrews, Timothy Morse
  • Patent number: 10968567
    Abstract: A method for preparing ?-cellulose, a spinning composition, and a fiber material are provided. The method for preparing ?-cellulose includes providing a coffee residue; subjecting the coffee residue to a decolorization treatment, obtaining a white powder; reacting the white powder with an alkaline solution, obtaining a mixture; filtering the mixture to produce a filter cake; and baking the filter cake to obtain ?-cellulose.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: April 6, 2021
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Shi-Kuang Hwang, Tien-Ching Lu, Kai-Jen Hsiao, Jing-Wen Tang
  • Patent number: 10959934
    Abstract: A micro- or nanoparticular vesicle comprises at least a crosslinked hyaluronic acid (HA), wherein the crosslinked hyaluronic acid is crosslinked by a chemical crosslinking agent, and wherein the degree of modification of said crosslinked hyaluronic acid with said chemical crosslinking agent is less than 1.9 mole %. Also disclosed are a method of manufacturing such vesicles, compositions comprising such vesicles and their uses.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: March 30, 2021
    Assignee: GALDERMA HOLDING SA
    Inventors: Claire Mallard, Yves Rival
  • Patent number: 10961323
    Abstract: Provided is a method for producing HPMCP capable of reducing the average particle size of HPMCP particles to an intended range without a pulverization step. Specifically provided is a method for producing hypromellose phthalate, comprising an esterification step of reacting hypromellose with an esterification agent in the presence of a catalyst to obtain a reaction solution containing crude hypromellose phthalate, a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose phthalate, thereby obtaining a hypromellose phthalate suspension, a liquid removal step of removing a liquid from the hypromellose phthalate suspension with a centrifugal decanter to obtain liquid-removed hypromellose phthalate, and a drying step of drying the liquid-removed hypromellose phthalate.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: March 30, 2021
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Mitsuhiro Yoshida, Junichi Matsubara
  • Patent number: 10934367
    Abstract: Provided is a method for producing HPMCAS capable of reducing the average particle size of HPMCAS particles to an intended range without a pulverization step. Specifically provided is a method for producing hypromellose acetate succinate, comprising an esterification step of reacting hypromellose with an esterification agent in the presence of a catalyst to obtain a reaction solution containing crude hypromellose acetate succinate, a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose acetate succinate, thereby obtaining a hypromellose acetate succinate suspension, a liquid removal step of removing a liquid from the hypromellose acetate succinate suspension with a centrifugal decanter to obtain liquid-removed hypromellose acetate succinate, and a drying step of drying the liquid-removed hypromellose acetate succinate.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: March 2, 2021
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Mitsuhiro Yoshida, Junichi Matsubara, Kazuki Kikuchi
  • Patent number: 10918585
    Abstract: Provided is an anti-aging agent for skin which contains, as an active component, an inositol derivative in which a monosaccharide or an oligosaccharide is bonded to inositol, in which a total amount of the monosaccharide or the oligosaccharide bonded to one inositol molecule is 2 or greater in terms of monosaccharide unit.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: February 16, 2021
    Assignee: SHOWA DENKO K.K.
    Inventors: Yuko Nakagami, Shinji Yamaki, Ichiro Fujita, Tadashi Yoneda
  • Patent number: 10906992
    Abstract: There is provided a method for producing a low polymerization degree cellulose ether having a less yellowish appearance and having excellent long-term storage stability through depolymerization of a high polymerization degree cellulose ether with an acid and without requiring an additive other than the acid. More specifically, there is provided a method for producing a low polymerization degree cellulose ether, including a step of depolymerizing a high polymerization degree cellulose ether with an acid to obtain a low polymerization degree cellulose ether mixture and a step of neutralizing the acid present in the low polymerization degree cellulose ether mixture, wherein ultraviolet is applied in the step of depolymerizing or between the steps of depolymerizing and neutralizing.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: February 2, 2021
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Taishi Kitaguchi, Akira Kitamura, Shintaro Matsusue, Mitsuhiro Yoshida
  • Patent number: 10899850
    Abstract: Methods for producing refined xylan from a biomass solution, including: (i) providing a biomass solution, which comprises xylan; (ii) concentrating or separating said biomass solution to obtain a xylan concentrate comprising xylan and impurities; (iii) washing and/or extracting the xylan concentrate with a solvent to obtain refined xylan and a solvent stream comprising the solvent and impurities; and (iv) collecting the refined xylan.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: January 26, 2021
    Assignee: Stora Enso OYJ
    Inventors: Jari Kavakka, Mari Granstrom