Patents Examined by Shaojia Anna Jiang
  • Polysaccharide suitable to modulate immune response
    Patent number: 9260535
    Abstract: Objective of the present invention is to provide polysaccharides which modulate immune response, and which can be used as ingredients in edible products or pharmaceutical compositions. The present invention provides such polysaccharides obtained from the species Camellia sinensis, which comprise a rhamnogalacturonan-I core, and wherein the molar ratio of galacturonyl acid residues to rhamnosyl residues in the backbone of the polysaccharide is close to 1:1. The present invention also provides edible products or pharmaceutical compositions containing such polysaccharides, in order to modulate immune response.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: February 16, 2016
    Assignee: NutriLeads B.V.
    Inventors: Ruud Albers, Jari Helin, Werner Klaffke, Jean Hypolites Koek, Petronella Anna Kreijveld, Jari Natunen, Erwin Werner Tareilus, Richardus Paulus Anton Oranje
  • Aminoglycoside antibiotics
    Patent number: 9260465
    Abstract: This invention relates to novel aminoglycoside antibiotics, which have potent antimicrobial activity against bacteria, which induce infectious diseases, particularly MRSA, and has no significant nephrotoxicity, and process for producing them. More particularly, the present invention relates to compounds represented by formula (Ia) or their pharmacologically acceptable salts or solvates, or their diastereomer mixtures, antimicrobial agents comprising them, and a process for producing them.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: February 16, 2016
    Assignees: MEIJI SEIKA PHARMA CO., LTD., MICROBIAL CHEMISTRY RESEARCH FOUNDATION
    Inventors: Yoshihiko Kobayashi, Yoshihisa Akiyama, Takeshi Murakami, Nobuto Minowa, Masaki Tsushima, Yukiko Hiraiwa, Shoichi Murakami, Mitsuhiro Abe, Kazushige Sasaki, Shigeru Hoshiko, Toshiaki Miyake, Yoshiaki Takahashi, Daishiro Ikeda
  • N-acylamino acid derivatives of cellulose or starch based polysaccharides and emulsified products containing the same
    Patent number: 9243075
    Abstract: To provide a novel substance having an excellent water-dispersibility capable of forming an emulsion which spreads rapidly onto the skin, does not undergo aggregation or segregation due to a salt, and is excellent in a low temperature stability. The aforementioned problems were found to be solved by means of a certain polysaccharide and the invention was established.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: January 26, 2016
    Assignee: Ajinomoto Co., Inc.
    Inventors: Masayuki Kuramoto, Tatsuya Hattori, Masahiro Ino
  • Treatment of symptoms associated with bacterial vaginosis
    Patent number: 9241997
    Abstract: The invention relates to the use of saccharide, such as lactose for the preparation of a medicament for the treatment and/or prophylaxis of one or more symptoms caused by bacterial vaginosis, wherein the medicament comprises at least 20 percent by weight of saccharide, and wherein the medicament is substantially free from bacteria. Furthermore, the invention relates to a method for treating one or more symptoms associated with bacterial vaginosis, as well as a pharmaceutical composition comprising the saccharide.
    Type: Grant
    Filed: June 11, 2004
    Date of Patent: January 26, 2016
    Assignee: IDH Holding ApS
    Inventor: Inge Dorthe Hansen
  • Production of 6?-O-sialyllactose and intermediates
    Patent number: 9237764
    Abstract: The present invention relates to a method for preparation of the trisaccharide 6?-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6?-O-sialyllactose salts in pharmaceutical or nutritional compositions.
    Type: Grant
    Filed: February 21, 2011
    Date of Patent: January 19, 2016
    Assignee: Glycom A/S
    Inventors: Ignacio Figueroa Pérez, Ferenc Horváth, Gyula Dekany, Károly Ágoston, Ágnes Ágoston, István Bajza, Julien Boutet, Markus Hederos, Piroska Kovács-Pénzes, Lars Kröger, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas, Christian Risinger
  • Antidiabetic enolic glucoside of phenylpyruvic acid
    Patent number: 9221860
    Abstract: There is provided an antidiabetic enolic glucoside of phenylpyruvic acid and derivatives thereof for use as medicaments, especially normoglycemic agents, i.e. for lowering blood glucose levels to normal levels in mammals that are obese, pre-diabetic or have diabetes, obesity and/or syndrome X. Hence the compounds of the present invention help to manage blood sugar levels, i.e. helping the body by balancing the blood sugar levels; helping to keep balanced blood glucose levels, particularly in humans with diabetes; aiding by enhancing the glucose uptake by the cells and by reducing sugar levels, thus improving or restoring the glucose tolerance; optimizing the glycemic response; normalizing the glucose tolerance.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: December 29, 2015
    Assignee: ZADEC APS
    Inventors: Elizabeth Joubert, Stephen John Fey, Johan Louw, Trond Ulven, Rahul Tyagi
  • Compositions including triciribine and one or more platinum compounds and methods of use thereof
    Patent number: 9211299
    Abstract: This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: December 15, 2015
    Assignee: University of South Florida
    Inventors: Jin Q. Cheng, Said M. Sebti
  • Anti-cancer therapies
    Patent number: 9205098
    Abstract: Methods for the treatment of cancer are described. In particular, methods for treatment of cancer comprising administration of glufosfamide alone or in combination with another anticancer agent are disclosed.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: December 8, 2015
    Assignee: Threshold Pharmaceuticals
    Inventor: George Tidmarsh
  • Hybrid compounds containing polysaccharide(s) and at least one polyoxyalkylene, method for preparing same, and applications thereof
    Patent number: 9206291
    Abstract: The invention relates to novel hybrid compounds containing at least one polysaccharide entity (PS), such as guar, in which at least one hydroxyl function is substituted by at least one A polyoxyalkylene entity (PEG). The swivel Ro between the entity PS and the entity A is obtained by click chemistry and has the following formula (IL1) or (IL2), in which Z is a carbon or nitrogen atom. These hybrid compounds can be used as emulsifiers, particularly in cosmetics.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: December 8, 2015
    Assignee: RHODIA OPERATIONS
    Inventors: Etienne Fleury, Morgan Tizzotti, Mathias Destarac, Marie-Pierre Labeau, Thíerry Hamaide, Eric Drockenmuller
  • 5?-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
    Patent number: 9193752
    Abstract: Provided herein are novel 5?-(S)—CH3 substituted bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, the furanose ring of each of the novel 5?-(S)—CH3 substituted bicyclic nucleosides includes a 2? to 4? bridging group. The 5?-(S)—CH3 substituted bicyclic nucleosides are expected to be useful for enhancing one or more properties of the oligomeric compounds they are incorporated into such as for example increasing the binding affinity. In certain embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: November 24, 2015
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Michael T. Migawa, Thazha P. Prakash, Charles Allerson, Balkrishen Bhat, Punit P. Seth, Eric E. Swayze
  • Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
    Patent number: 9192645
    Abstract: This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: November 24, 2015
    Assignee: University of South Florida
    Inventors: Jin Q. Cheng, Said M. Sebti
  • Compositions including triciribine and trastuzumab and methods of use thereof
    Patent number: 9186403
    Abstract: This application relates to combination therapies including triciribine and related compounds and trastuzumab or a salt thereof and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: November 17, 2015
    Assignee: University of South Florida
    Inventors: Jin Q. Cheng, Said M. Sebti
  • Uracil derivatives and use thereof
    Patent number: 9181199
    Abstract: Disclosed are uracil derivatives of the formula (I): wherein R1, R2, R3, and X are as defined herein, and use thereof as therapeutic agents. The uracil derivatives are used in particular together with a cytostatic agent for suppressing or reducing resistance building up on cytostatic treatment.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: November 10, 2015
    Assignee: RESprotect GmbH
    Inventors: Rudolf Fahrig, Kurt Eger, Martin Fuhrer, Nicole Heinze, Matthias Klemm, Jorg-Christian Heinrich
  • Methods for preparation of glycosphingolipids and uses thereof
    Patent number: 9181292
    Abstract: Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of ?-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: November 10, 2015
    Inventor: Pi-Hui Liang
  • Method for the synthesis of aspalathin and analogues thereof
    Patent number: 9181293
    Abstract: A method of synthesising Aspalathin and its analogues or derivatives is disclosed. The method comprises synthesising a compound of formula 1 or its analogues or derivatives: wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 is independently selected from the group consisting of —H, —OH, hydrocarbyl groups, saccharide moieties and —OR15; R15 is selected from the group consisting of hydrogen, a hydrocarbyl group (e.g. methoxy or ethoxy), an acyl group and a benzyl group; and R11, R12, R13 and R14 are independently selected from the group consisting of —H, hydrocarbyl groups, saccharide moieties, an acyl group and a benzyl group.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: November 10, 2015
    Assignee: South African Medical Research Council
    Inventors: Jan Hendrik Van der Westhuizen, Daneel Ferreira, Elizabeth Joubert, Sussana Lucia Bonnet
  • Method of recycling fibers from sewage sludge and means thereof
    Patent number: 9169597
    Abstract: The present invention generally relates to a method of recycling and producing fibers from sewage sludge, such as streams of municipal, agricultural and industrial flowing wastes to be further processed. The present invention also relates to industrial means adapted for recycling the same. The present invention discloses environmentally friendly processes and means for recovering valuable fibers and especially cellulose fibers and the like from agricultural and/or urban sewage sludge, waste and/or industrial effluents to decrease its volume especially BOD and TSS, obtaining valuable raw materials and decreasing environmental damages.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: October 27, 2015
    Assignee: Applied Cleantech Inc.
    Inventor: Refael Aharon
  • Inhibitors of glycolysis useful in the treatment of brain tumors
    Patent number: 9149489
    Abstract: Provided herein are methods of treating brain tumors by administering a therapeutically effective amount of a compound of the Formulas I or II to a patient in need thereof.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: October 6, 2015
    Assignee: Board of Regents, University of Texas System
    Inventors: Waldeman Priebe, Charles Conrad, Timothy Madden, Izabela Fokt, Slawomir Szymanski, Leposava Antonovic
  • Dermal filler compositions including antioxidants
    Patent number: 9149422
    Abstract: Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: October 6, 2015
    Assignee: Allergan, Inc.
    Inventors: Futian Liu, Xiaojie Yu, Nicholas J. Manesis
  • Polymer made of a primary amine functionalized polymer and a hemicellulose
    Patent number: 9133578
    Abstract: The present invention relates to a polymer made of a primary amine functionalized polymer and a hemicellulose e.g. chitosan and xyloglucan, wherein the primary amine functionalized polymer is covalently bound to the hemicellulose, and to a cross-linking agent composition comprising the polymer. A method wherein manufacturing a cellulose containing product comprises the steps of; providing a cellulose containing product; treating said cellulose product with a cellulose adsorbing agent comprising a polymer made of a primary amine functionalized polymer and a hemicellulose e.g. chitosan and xyloglucan, and optionally other additives is also provided.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: September 15, 2015
    Assignee: CELLUTECH AB
    Inventors: Marcus Ruda, Rikard Slätteg{dot over (a)}rd
  • Hydrazone derivatives having potent antitumor activity toward multi-drug resistant tumor cells
    Patent number: 9133230
    Abstract: A patentable new class of hydrazone derivative compounds is described, as are methods for synthesizing such compounds. The hydrazones of the invention can be used, for example, as potent anti-cancer agents, including to inhibit the growth of cancer cells that exhibit multidrug resistance.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: September 15, 2015
    Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Hiremagular N. Jayaram, Praveen Kusumanchi, Mario Grifantini, Palmarisa Franchetti, Loredana Cappellacci, Riccardo Petrelli