Patents Examined by Shawquia Jackson
  • Patent number: 10442754
    Abstract: A family of amine mining collectors that uses alkoxylates allows for the easy adjustment of solubility and molecular weight useful because anionic and cationic mineral collectors require such varying degrees of solubility and molecular weight. The family of the present invention allows for the optimization of both parameters and an increase in collector efficiency.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: October 15, 2019
    Inventor: Thomas P. Daly
  • Patent number: 10442804
    Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: October 15, 2019
    Inventors: Evangelos Aktoudianakis, Eda Canales, Kevin S. Currie, Darryl Kato, Jiayao Li, John O. Link, Samuel E. Metobo, Roland D. Saito, Scott D. Schroeder, Nathan Shapiro, Winston C. Tse, Qiaoyin Wu, Yunfeng Eric Hu
  • Patent number: 10441618
    Abstract: A moringa extract containing a benzyl glucosinolate in a content of 6% by mass or more, calculated as a dry solid content of the extract, wherein the extract does not substantially contain an alkaloid. The moringa extract of the present invention for solving a first aspect is useful in the field of foodstuff or the like. Also, the PPAR activator of the present invention for solving a second aspect has excellent PPAR activation action, and has no disadvantages in side effects, so that it can be ingested for long term, which can be preferably used in foodstuff and the like. Therefore, the PPAR activator of the present invention for solving a second aspect can be expected to be used as a food, a supplement or a medicament not only for prevention of disease such as insulin resistance, hyperinsulinism, Type 2 diabetes, hypertension, hyperlipidemia, arterial sclerosis and obesity, but also for fatigue recovery or endurance improvement by improving basal metabolism.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: October 15, 2019
    Assignee: TAIYO KAGAKU CO., LTD.
    Inventors: Kazuhiko Sugiura, Aditya Kulkarni
  • Patent number: 10435352
    Abstract: A process for preparing 2-alkyl-4-trifluoromethyl-3-alkylsulfonylbenzoic acids of the formula (I) is described. Here, the substituents are radicals such as alkyl and substituted phenyl.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: October 8, 2019
    Assignee: Bayer CropScience Aktiengesellschaft
    Inventors: Christian Funke, Thomas Himmler, Sergii Pazenok, Christoph Schotes, Matthias Beller, Thomas Schareina, Alexander Zapf
  • Patent number: 10435355
    Abstract: Described herein, inter alia, are compositions and methods useful for inhibiting fatty acid amide hydrolase.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: October 8, 2019
    Assignees: The Regents of the University of California, Fondazione Istituto Italiano di Tecnologia
    Inventors: Daniele Piomelli, Tiziano Bandiera, Rita Scarpelli
  • Patent number: 10433552
    Abstract: This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: October 8, 2019
    Assignee: MERIAL, INC.
    Inventors: Chunhua Yang, Loic Patrick Le Hir de Fallois, Charles Q. Meng, Alan Long, Roelof Johannes Gorter de Vries, Bruno Baillon, Sylvaine Lafont, Myriam Gay de Saint Michel, Stephane Kozlovic
  • Patent number: 10428094
    Abstract: Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R12 or R13 on the A group is an amide substituent (R32) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: October 1, 2019
    Assignee: Achillion Pharmaceuticals, Inc.
    Inventors: Jason Allan Wiles, Qiuping Wang, Venkat Rao Gadhachanda, Godwin Pais, Akihiro Hashimoto, Dawei Chen, Xiangzhu Wang, Atul Agarwal, Milind Deshpande, Avinash S. Phadke
  • Patent number: 10420741
    Abstract: The present invention includes cilastatin or a pharmaceutically acceptable salt thereof as an active component and a suppressant for renal impairment or inner ear disorders, induced via megalin by at least one megalin ligand which is selected from the group consisting of polymyxins, aminoglycoside antibiotics, glycopeptide antibiotics, cisplatin, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: September 24, 2019
    Assignees: EA Pharma Co., Ltd., Niigata University
    Inventors: Akihiko Saito, Nobumasa Aoki, Yoshihisa Hori, Shoji Kuwahara, Michihiro Hosojima, Hiroshi Iwata, Saori Matsuda
  • Patent number: 10421719
    Abstract: The present invention relates to a salt of formula (I), the preparation method for preparing same, and the use thereof in the preparation of silodosin.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: September 24, 2019
    Assignee: URQUIMA S.A.
    Inventors: José Luis Del Río Pericacho, Xavier Vila Tusell
  • Patent number: 10414726
    Abstract: A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: September 17, 2019
    Inventors: Bernard Thomas Golding, Christiane Riedinger, Roger John Griffin, Ian Robert Hardcastle, Eric Valeur, Anna Frances Watson, Martin Noble
  • Patent number: 10414733
    Abstract: The present invention relates to a process for preparing a pyrazole compound of formula V, the process including cyclizing a hydrazone substituted ?,?-unsaturated carbonyl compound of formula IV by reacting it with a suitable reagent, e.g. a reducing agent, an organometallic reagent or a nucleophilic reagent. The compounds of formula V are versatile reaction tools for the preparation of pyrazole derived fine chemicals. The present invention also relates to pyrazole compounds of formulae Va, Vb, Vc, and VI.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: September 17, 2019
    Assignee: BASF SE
    Inventors: Birgit Gockel, Daniel Saelinger, Sebastian Soergel, Michael Rack
  • Patent number: 10407388
    Abstract: Provided is a compound activating ROR? gene, particularly a JC1 compound containing CGP52608 thiazolidinedione as a lead substance, and a pharmaceutically acceptable salt thereof. The compound is a lipid accumulation inhibitor and applicable to the treatment of metabolic diseases or inflammatory diseases.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: September 10, 2019
    Inventors: Mi Ock Lee, Hyeung Geun Park, Eun Jin Kim, Ho Young Son, Hyo Jun Jung, Suck Chang Hong, Tae Young Na
  • Patent number: 10407384
    Abstract: The present invention relates to compounds which are suitable as synthesis precursors for the production of electronically active materials for use in organic electroluminescence devices.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: September 10, 2019
    Assignee: Merck Patent GmbH
    Inventors: Philipp Stoessel, Amir Hossain Parham, Anja Jatsch
  • Patent number: 10399940
    Abstract: The invention discloses compounds of Formula (I) wherein R1, R2, R2A, R3, R3A, R4, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: September 3, 2019
    Assignees: AbbVie S.á.r.l., Galapagos NV
    Inventors: Robert J. Altenbach, Andrew Bogdan, Nicolas Desroy, Gregory A. Gfesser, Stephen N. Greszler, John R. Koenig, Philip R. Kym, Bo Liu, Marc J. Scanio, Xenia Searle, Xueqing Wang, Ming C. Yeung, Gang Zhao
  • Patent number: 10403445
    Abstract: A process for the synthesis of ?-conjugated materials including a step of utilizing a synthon having a carbazole or fluorene nucleus.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: September 3, 2019
    Inventors: Martial Degbia, Bruno Schmaltz, François Tran-Van
  • Patent number: 10399939
    Abstract: Described herein are tetrahydronaphthalene compounds with estrogen receptor modulation activity or function having the Formula I structure: and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such estrogen receptor modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: September 3, 2019
    Assignee: Genentech, Inc.
    Inventors: Jun Liang, Daniel Fred Ortwine, Xiaojing Wang, Jason Zbieg
  • Patent number: 10392383
    Abstract: 4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of a 4-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: August 27, 2019
    Assignee: Samumed, LLC
    Inventors: Sunil Kumar KC, David Mark Wallace, Jianguo Cao, Chandramouli Chiruta, Joseph Timothy Marakovits, Venkataiah Bollu, John Hood
  • Patent number: 10392396
    Abstract: Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in signaling pathways in cancer and metastasis. Methods for treatment of cancer and hyperproliferative diseases are disclosed.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: August 27, 2019
    Assignee: University of Puerto Rico
    Inventors: Cornelis P. Vlaar, Suranganie Dharmawardhane Flanagan, Eliud Hernandez-O'Farrill, Linette Castillo-Pichardo
  • Patent number: 10385214
    Abstract: The present application relates to new fluorescent dyes and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: August 20, 2019
    Assignee: Illumina Cambridge Limited
    Inventor: Nikolai Romanov
  • Patent number: 10388888
    Abstract: Charged organic thermally activated delayed fluorescence (TADF) species are described. A light-emitting electrochemical cell (LEEC) includes the charged organic thermally activated delayed fluorescence (TADF) species and sufficient counter ions to balance the charge on the charged organic thermally activated delayed fluorescence species, as emitter material. Also disclosed are OLEDSs containing the TADF species.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: August 20, 2019
    Inventors: Eli Zysman-Colman, Michael Yin Wong