Abstract: Disclosed are novel protein and peptide compositions comprising soluble and bound forms of immunologically-active blood group antigens including mammalian Rh antigens. In preferred embodiments methods for the isolation and purification of serologically-active human Rh antigens such as D, c, C, E, and e are disclosed. Also disclosed are methods for the adsorption of immunologically-active Rh antigens to solid supports. Diagnostic kits, methods, and devices for the detection of Rh antibodies in clinical and non-clinical samples are also disclosed. Devices, compositions and methods for the isolation, purification and quantitation of anti-Rh antibodies from solution are also provided.
Type:
Grant
Filed:
September 17, 1996
Date of Patent:
November 24, 1998
Assignees:
Baylor College of Medicine, Board of Regents, The University of Texas System
Inventors:
L. Scott Rodkey, Marwan A. Yared, Kenneth J. Moise, Jr.