Patents Examined by Sheera J. Huff
  • Inhibitors of dipeptidyl-aminopeptidase type IV
    Patent number: 5462928
    Abstract: The invention features an inhibitor of DP-IV, having the structure: ##STR1## wherein m is an integer between 0 and 10, inclusive; A and A' are L-amino acid residues such that the A in each repeating bracketed unit can be a different amino acid residue; the C bonded to B is in the L-configuration; the bonds between A and N, A' and C, and between A' and N are peptide bonds; and each X.sup.1 and X.sup.2 is, independently, a hydroxyl group or a group capable of being hydrolyzed to a hydroxyl group at physiological pH.
    Type: Grant
    Filed: July 15, 1993
    Date of Patent: October 31, 1995
    Assignees: New England Medical Center Hospitals, Inc., Tufts University
    Inventors: William W. Bachovchin, Andrew G. Plaut, Flentke George R.