Abstract: The present invention provides a periodontal composition compounded to include at least one alkaline agent to render a gel or paste having a pH of at least 9.0 to 11.0, and preferably 9.5 to 10.0. The preferred alkaline agent included in the composition is potassium hydroxide, and the composition preferably also includes aluminum hydroxide, calcium carbonate and magnesium carbonate. Of these agents, potassium hydroxide is the most basic compound utilized.

Abstract: The present invention relates to the use of 2-amino-4,5,6,7-tetrahydro-6-propylamino-benzothiazole (pramipexole), the (+)- or (−)-enantiomer thereof or one of the pharmacologically acceptable salts thereof in conjunction with another antidepressant for the improved treatment of depression and depressive states.

Abstract: Disclosed are methods for reducing the staining of dentifrice composition containing stannous comprising administering to a subject the dentifrice composition. The dentifrice composition is a dual phase dentifrice and is contained in physically separated compartments of a dentifrice dispenser. The first dentifrice composition comprises an effective amount of one or more linear polyphosphates having an average chain length of about 4 or more and has a total water content of up to about 20%. The second dentifrice composition comprises an effective amount of stannous ions. The molar ratio of polyphosphate anion to stannous ion is from about 0.2:1 to about 5:1 and the efficacy of the stannous ion in the dentifrice is not reduced by the polyphosphate. The dentifrice composition may alternatively be a single phase dentifrice.

Abstract: Intervention for oral mucosal injury secondary to chemotherapy or radiation based on the inhibition in the synthesis of ceramide, blockage of its activity, or its digestion.

Abstract: The present invention discloses a tooth cleaning composition and applicator that is particularly adapted for clearing and cleaning the area of the teeth in preparation of fillings or orthodontic appliances, such as braces or bridges. The cleaning agent of the present invention consists of various size ground pumice with a water soluble lubricant binder. The present invention limits the tendencies of spatter and overcomes prior art uses of ground pumice in dental applications.

Abstract: Aqueous oral and dental care compositions are comprising of: (a) from about 0.1 to about 20% by weight of surfactant granules which are the product of the process which comprises subjecting an aqueous paste comprised of from about 40 to about 60% by weight of a monoglyceride (ether) sulfate to simultaneous drying and granulation in a fluidized bed; (b) from about 1 to about 25% by weight of an abrasive, a polish, or a combination thereof; (c) from 0 to about 65% by weight of a humectant; (d) from 0 to about 2% by weight of chitosan; (e) from 0 to about 3% by weight of a flavoring and; (f) from 0 to about 5% by weight other auxiliaries including water wherein the weight of all components adds up to 100% by weight.

Abstract: A two component antiplaque dentifrice composition is disclosed which comprises first and second dentifrice components containing an enzyme such as papain and a metal salt such as stannous fluoride, the first and second dentifrice components being maintained separate from the other until dispensed for application to teeth.

Abstract: The present invention provides a formulation for the delivery of bioactive constituents to biological surfaces, wherein said formulation comprises a suspensions or solution of at least one isolated and purified casein protein or salt thereof, in water, together with at least one bioactive constituent.

Abstract: Disclosed is a delivery system for delivering an oral care substance to the oral cavity, the delivery system comprising: (a) a removable backing strip having sufficient flexibility so as to be readily conformable to an oral surface when the delivery system is placed thereagainst; and (b) an oral care composition applied to the strip of material such that when the delivery system is placed on the oral surface the oral care composition contacts the oral surface, the oral care composition comprising: (i) an organosiloxane resin; (ii) a theology modifier; and (iii) at least one oral care substance; wherein the oral care composition remains on the oral surface after the backing strip is removed. Further disclosed are such delivery systems in which the oral care composition further comprises fluid diorganopolysiloxane-based polymers; such compositions may further comprise carriers for solubilizing the organosiloxane resin and the fluid diorganopolysiloxane-based polymers.

Abstract: A anhydrous tooth and gum powdered dentifrice formulated of calcium or magnesium peroxide, sodium bicarbonate, methylsufonymethane, ascorbic acid, colostrum, and optionally menthol, flavoring agent, sweetening agent, sodium laurel sulfate and green tea extract that has a long shelf life but when activated by water or saliva, functions to effect a synergistic chemical and mechanical action to whiten, brighten, polish teeth and reduce bacteria so as to aid in the prevention and treatment of periodontal disease, dental caries and mouth odor.

Abstract: A kit and associated method in which symptoms of nicotine withdrawal syndrome are relieved as well as addressing the associated weight gain issues and craving for sweets by combining nicotine replacement therapy with complementary dosages of xylitol.

Abstract: A non-invasive and non-systemic method for intradermal prevention OR amelioration of pain from a surgically closed wound is disclosed. The method comprises topical delivery of a local anesthetic to an exterior surface of a surgically closed wound.

Abstract: A composition of matter comprising particles of silica, where the silica particles have surfaces at which condensed phosphate is retained, and a production methodology therefor. Oral compositions containing this composition of matter are also presented, which are endowed with enhanced cleaning efficacy.

Abstract: A device is provided for the treatment of teeth including an outer layer of non-porous polymeric material forming a trough, an inner layer forming an inner lining of the trough, and a treatment layer including a treatment agent disposed between the outer layer and the inner layer. The inner layer allows penetration of the treatment agent through after an aqueous solution is introduced to the device. A device is provided for the treatment of teeth including an outer layer of non-porous polymeric material in the form of a trough, wherein the trough has an outside and an inside surface. An outer lining layer is proximate to the inside surface of the outer layer; the outer lining layer includes a material for retaining a treatment agent. An inner lining layer forms an inner lining of the trough, wherein the inner lining layer includes a water-permeable material. A treatment layer is disposed between the inner lining layer and the outer lining layer, wherein the treatment layer includes a treatment agent.

Abstract: Dental compositions are provided that can be delivered as a fine mist and that have the capability of undergoing an increase in viscosity in response to an increase in temperature. In a preferred embodiment, the compositions also have the ability to reverse their viscosity in response to a decrease in temperature.

Abstract: The invention relates to the use of surfactant mixtures, comprising (a) anionic and/or nonionic surfactants and (b) water soluble &bgr;-(1,3) glucans, which are substantially free of &bgr;-(1,6) links. Said mixtures are used to produce oral hygiene and dental hygiene products in particulars, toothpastes. The preparations are characterized in that the mucous membranes in the mouth have a particularly high degree of tolerability with regard thereto, by exhibiting exceptional foaming properties and a stable distribution of the abrasive substances.

Abstract: A dual component chlorhexidine dentifrice composition of improved shelf stability in which the first component is a gel containing a bis-biguanide antibacterial agent in which the gel vehicle is thickened with a cellulose polymer and the second component is a paste containing a silica abrasive wherein the bis-biguanide antibacterial agent provides undiminished antiplaque and antigingivitis effect with reduced staining when the physically separated components are combined and mixed upon application to dental tissue.

Abstract: A silica comprising at least two silica fractions, wherein the at least two silica fractions differ by at least 10% in at least one of their BET surface area values, their CTAB surface area values or their DBP absorption values, the ranges of these three physicochemical properties being as follows: BET surface area 30-300 m2/g CTAB surface area 30-300 m2/g DBP absorption 80-300 g/100 g.

Abstract: This invention relates to novel dental compositions and methods for preventing dental plaque and carie formation and generally for inhibiting tooth decay and brightening/whitening teeth. The compositions of this invention comprise organic acids such as acetic acid and salts thereof which can be combined with pharmaceutically acceptable carriers or diluents to be administered in the form of conventional dental compositions. The compositions of the present invention also preferably contain sodium hexametaphosphate.

Abstract: Therapeutic composition having anti-infective activity. The therapeutic composition is a formulation comprising an antibiotic, preferably a tetracycline, most preferably doxycycline, which has not been chemically modified to eliminate antimicrobial efficacy. The antibiotic is preferably in a liquid vehicle, most preferably one that contains at least 20% alcohol by volume. The therapeutic composition is preferably in local delivery form and is self-administered orally or via the nasal cavity.