Patents Examined by Sheridan L. Swope
  • Methods and compositions for modulating ACE-2 activity
    Patent number: 6592865
    Abstract: The invention relates to the use of angiotensin II in combination with angiotesin 1-9 to potentiate angiotensin II activity. The invention also relates to the use of combinations of angiotensin II and angiotensin 1-9 to increase vasoconstriction and to treat disorders associated with low blood pressure.
    Type: Grant
    Filed: June 3, 2002
    Date of Patent: July 15, 2003
    Assignee: Human Genome Sciences, Inc.
    Inventors: Tom J. Parry, Les Sekut
  • Isoprenoid production
    Patent number: 6586202
    Abstract: The present invention relates to an isolated DNA sequence encoding an enzyme in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate. Vectors and plasmids including such DNA are also set forth. The invention also includes host cells transformed by such DNAs, or vectors or plasmids containing such DNAs. A process for the production of isoprenoids and carotenoids using such transformed host cells is also provided.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: July 1, 2003
    Assignee: Roche Vitamins, Inc.
    Inventors: Tatsuo Hoshino, Kazuyuki Ojima, Yutaka Setoguchi
  • Oxaloacetate hydrolase deficient fungal host cells
    Patent number: 6544765
    Abstract: The present invention relates to isolated nucleic acid sequences encoding polypeptides having oxaloacetate hydrolase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as recombinant methods for producing the polypeptides.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: April 8, 2003
    Assignee: Novozymes, A/S
    Inventors: Carsten Mailand Hjort, Henrik Pedersen
  • Recombinantly producing levodione reductase
    Patent number: 6534297
    Abstract: The present invention is directed to genetic material useful for the preparation of actinol, such as an isolated DNA including a nucleotide sequence coding for an enzyme having levodione reductase activity, a polypeptide encoded by such a DNA, recombinant organisms, and the like. These genetic materials may originate from Corynebacterium, Cellulomonas, Planococcus, Arthrobacter, and the like. The present invention also provides a process for the production of actinol.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: March 18, 2003
    Assignee: Roche Vitamins, Inc.
    Inventors: Sakayu Shimizu, Masaru Wada
  • Glutaryl cephalosporin amidase from Pseudomonas diminuta BS-203
    Patent number: 6528300
    Abstract: The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-&bgr;-(4-carboxybutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The invention also provides nucleic acid sequences, vectors, and host cells useful in the production of this amidase. The glutaryl 7-ACA amidase can be used for the preparation of 7-aminocephalosporanic acid.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: March 4, 2003
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Ross Binder, Joanne L. Brown, Thomas J. Franceschini, William V. Burnett, Michael Politino, Suo Win Liu, Sean M. Tonzi
  • Enzyme or cell preparation with inulinase activity
    Patent number: 6518047
    Abstract: The present invention is related to an isolated and purified enzyme with inulinolytic activity having more than 75% sequence identity with the amino acid sequence SEQ ID NO 12 to its encoding nucleotidic sequence to a cell producing the enzyme and to the use for the degradation of inulin or inulin-containing plant material, especially for the production of fructose syrups and for the production of oligomers of fructose.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: February 11, 2003
    Assignee: Puratos Naamloze Vennootschap
    Inventors: Jean-Luc Jonniaux, Karl Rauw, Philippe Thonart, Thierry Dauvrin
  • Isolated human phosphatase proteins, nucleic acid molecules encoding human phosphatase proteins, and uses thereof
    Patent number: 6479270
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphatase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phosphatase peptides, and methods of identifying modulators of the phosphatase peptides.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: November 12, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Human proteases and polynucleotides encoding the same
    Patent number: 6448388
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: August 15, 2001
    Date of Patent: September 10, 2002
    Assignee: Lexicon Genetics Incorporated
    Inventors: Carl Johan Friddle, Erin Hilbun