Patents Examined by Shirley V. Gembeh
  • Use of CDK9 inhibitors to reduce cartilage degradation
    Patent number: 10639302
    Abstract: The present invention relates to the use of cyclin-dependent kinase 9 (CDK9) inhibitors to reduce, inhibit and/or prevent cartilage degradation. CDK9 inhibitors can be used to reduce, inhibit and/or prevent cartilage degradation and loss of cartilage viability during allograft storage. CDK9 inhibitors can be used as a post-injury intervention treatment to reduce, inhibit and/or prevent the acute cellular responses that lead to future cartilage degradation and osteoarthritis.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: May 5, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dominik Haudenschild, Paul Di Cesare, Jasper Yik, Blaine Christiansen
  • Method of administration and treatment
    Patent number: 10639326
    Abstract: Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: May 5, 2020
    Assignee: AMPERSAND BIOPHARMACEUTICALS, INC.
    Inventor: Ryan Beal
  • Method of administration and treatment
    Patent number: 10632146
    Abstract: Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: April 28, 2020
    Assignee: AMPERSAND BIOPHARMACEUTICALS, INC.
    Inventor: Ryan Beal
  • Cosmetic composition comprising a salicylic acid compound
    Patent number: 10617616
    Abstract: Cosmetic composition comprising a salicylic acid compound The invention relates to a composition in the form of an oil-in-water emulsion comprising: —a fatty acid ester of polyethylene glycol; —a C16-C22 fatty acid ester of glycerol; —a polycondensate of ethylene oxide and of propylene oxide constituted of polyethylene glycol and polypropylene glycol blocks; —an at least partially neutralized acrylic acid homopolymer; —a 2-acrylamido-2-methylpropanesulfonic acid polymer; —a salicylic acid compound. The composition has good stability, in particular after 15 days of storage at 55° C. Use for caring for and making up keratin materials.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: April 14, 2020
    Assignee: L'OREAL
    Inventors: Eric Lheureux, Patricia Pierre
  • Valproate as a topical anti-fungal treatment
    Patent number: 10617659
    Abstract: Valproate is useful as an antifungal agent. The valproate compositions can be used to treat fungal infections. The valproate compositions can be formulated as topical antifungals.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: April 14, 2020
    Assignee: Wayne State University
    Inventors: Miriam L. Greenberg, Rania M. Deranieh
  • Emulsifying system for microemulsions
    Patent number: 10603257
    Abstract: The present disclosure relates to antiperspirant and/or deodorizing cosmetic agent agents in the form of emulsions, which contain at least one non-ionic emulsifier a), wherein an ethoxylated, saturated, branched C14-C18 alcohol has an ethoxylation degree of from about 18 to about 22 ethylene oxide units, and at least one further non-ionic emulsifier b), wherein an ethoxylated, linear, mono-unsaturated C16-C20 alcohol has an ethoxylation degree of from about 18 to about 22 ethylene oxide units, wherein the weight ratio of the non-ionic emulsifier a) to the non-ionic emulsifier b) is from about 1.2:1 to about 4.0:1. The cosmetic agents as contemplated herein are optically transparent and have an improved storage stability, even under fluctuating temperatures.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: March 31, 2020
    Assignee: Henkel AG & Co. KGaA
    Inventor: Thomas Doering
  • Formulation for inhibiting formation of 5-HTagonists and methods of using same
    Patent number: 10603290
    Abstract: Drug combinations and their use are disclosed. A first drug is administered in combination with a second drug. The first drug such as fenfluramine is characterized by the formation of a metabolite including 5-HT2B agonists such as norfenfluramine with known adverse side effects. The second drug is in the form of a CYP inhibitor such as cannabidiol which modulates the formation of metabolite down thereby making the first drug safer.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: March 31, 2020
    Assignee: ZOGENIX INTERNATIONAL LIMITED
    Inventors: Stephen J. Farr, Brooks Boyd
  • Oil blend for microemulsions
    Patent number: 10596080
    Abstract: The present disclosure relates to antiperspirant and/or deodorizing cosmetic agents in the form of oil-in-water emulsions, which contain a combination of isopropylisostearate and isopropylmyristate as cosmetic oils and a small total quantity of oils and emulsifiers. The cosmetic agent as contemplated herein surprisingly have extremely low or no stickiness after their application to the skin. They can also be optically transparent and have improved storage stability.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: March 24, 2020
    Assignee: Henkel AG & Co. KGaA
    Inventors: Thomas Doering, Stefanie Schmitz
  • Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
    Patent number: 10596146
    Abstract: Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: March 24, 2020
    Assignee: Respivant Sciences GmbH
    Inventors: Pravin Soni, William Gerhart, Robert Craig Armstrong
  • Medium chain fatty acids and their triglycerides for treating anxiety
    Patent number: 10596137
    Abstract: The present invention provides a medium chain fatty acid (MCFA) for use in treating and/or preventing anxiety.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: March 24, 2020
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Ellen Siobhan Mitchell, Carmen Sandi
  • Compounds of fatty acids and ammonium fatty acid salts
    Patent number: 10588313
    Abstract: A compound containing one mole of a free fatty acid and one mole of the ammonium salt of the fatty acid and represented by the structural formula (I): CH3(CH2)xCOOH.CH3(CH2)xCOO?NH4+??(I) wherein x is 6, 7 or 8. Bacterial contaminated surfaces may be disinfected or bacteria removed from a bacterial contaminated surface by applying onto the surface a bactericidally effective amount of the compound.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: March 17, 2020
    Assignee: Falcon Lab, LLC
    Inventor: Robert A. Smiley
  • Compositions, uses and methods for making them
    Patent number: 10590134
    Abstract: Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods of making and using the same.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: March 17, 2020
    Assignee: PIMERA, INC.
    Inventor: Mustapha Haddach
  • Compositions and methods of treating cardiac fibrosis with ifetroban
    Patent number: 10583126
    Abstract: The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by administration of a therapeutically effective amount of ifetroban, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: March 10, 2020
    Assignees: CUMBERLAND PHARMACEUTICALS INC., Vanderbilt University
    Inventors: Leo Pavliv, Bryan Voss, James West, Erica Carrier
  • Aqueous composition for caring for and/or making up keratin materials comprising microcapsules encapsulating an oily dispersion of at least one reflective agent
    Patent number: 10576028
    Abstract: The present invention concerns a composition, in particular in the form of aqueous dispersion for caring for and/or making up keratin materials comprising, in a physiologically acceptable medium, a) one aqueous phase; and b) at least microcapsules comprising:—an inner core comprising at least a dispersion of at least one reflective agent, in particular bismuth oxychloride, in at least one oil, and—at least one outer shell formed of a wall-forming polymeric material surrounding the said core, the said outer shell comprising i) at least one wall-forming polymer, and ii) optionally at least one plasticizer and/or at least one opaque substance and/or at least one fatty acid salt. The present invention concerns also a cosmetic process for caring for and/or making up keratinic materials, comprising application on said keratinic materials in particular on the skin of a composition as above defined.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: March 3, 2020
    Assignee: L'OREAL
    Inventors: Audrey Ricard, Danny Goldstein
  • Salts of an epidermal growth factor receptor kinase inhibitor
    Patent number: 10570099
    Abstract: The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: February 25, 2020
    Assignee: Celgene CAR LLC
    Inventors: Mei Lai, Steven Richard Witowski, Richland Wayne Tester, Kwangho Lee
  • Delivery systems for propofol
    Patent number: 10568834
    Abstract: Provided is a novel dilutable delivery systems and propofol microemulsions suitable for intravenous delivery of propofol.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: February 25, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Nissim Garti, Sharon Garti Levi, Abraham Aserin, My Perlstein
  • Xanthone-rich plant extracts or compounds therefrom for modulating diseases of the central nervous system and related disorders
    Patent number: 10568862
    Abstract: The invention relates to a method of treatment and/or prophylaxis of a disease or disorder of the central nervous system comprising administering to a mammal in need thereof an effective amount of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract. The invention also relates to use of a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, in the preparation of a medicament for the treatment and/or prophylaxis of a disease or disorder of the central nervous system and to a xanthone-rich plant extract, or a compound derived from a xanthone-rich plant extract, for use in the treatment and/or prophylaxis of a disease or disorder of the central nervous system.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: February 25, 2020
    Assignee: DEAKIN UNIVERSITY
    Inventors: Michael Berk, Wendy Laupu
  • Composition in the form of nano- or micro-emulsion
    Patent number: 10561587
    Abstract: The present invention relates to a composition in the form of a nano- or micro-emulsion, comprising: (a) at least one oil; (b) at least one nonionic surfactant with an HLB value of from 8.0 to 14.0, preferably from 9.0 to 13.5, and more preferably from 10.0 to 13.0; (c) at least one ceramide compound; (d) at least one anionic surfactant; and (e) water. The composition can be used as a cosmetic composition and provides an excellent feeling during use and can be transparent or slightly translucent, and is stable over time, even at an elevated temperature.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: February 18, 2020
    Assignee: L'OREAL
    Inventors: Maki Koide, Anne-Laure Bernard
  • Topical preparation for skin tissue protection and reparation
    Patent number: 10561640
    Abstract: The present invention relates to a topical preparation for skin tissue protection and reparation. The complex preparation includes the following components: (1) polyethylene glycol; (2) water; and (3) flavonoid compound. The complex preparation may: (1) repair skin injury or promote wound healing; (2) eliminate scars; (3) prevent or treat skin injury caused by radiotherapy; and (4) prevent or treat radiodermatitis.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: February 18, 2020
    Assignee: NANJING JIANZHUANG BIOTECHNOLOGY LIMITED COMPANY
    Inventor: Wei Zeng
  • Method for preparing regenerated cellulose fibers having anti-bacteria, anti-mite and anti-mould functions and the use thereof
    Patent number: 10563322
    Abstract: The present invention provides a method for preparing regenerated cellulose fibers having anti-bacteria, anti-mite and anti-mould functions from a fennel extract, a Litsea cubeba extract, and a thyme essential oil. The present invention also relates to the use of the regenerated cellulose fiber prepared by the above method in the field of anti-bacteria, anti-mite and mildew-resistant fabrics. The invention solves the technical defect that regenerated cellulose fibers have a single function and has poor anti-mite and anti-mould effects in the prior art.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: February 18, 2020
    Assignee: Infinitus (China) Company Ltd.
    Inventors: Jiao Wu, Chen Zhang, Liuyun Hu