Patents Examined by Shizhi Qian
  • Patent number: 12228480
    Abstract: Systems and methods use electric fields to separate bioanalytes from a substrate comprising a biological sample. Biological material, especially blood samples, are sometimes dried onto absorbent substrates. By applying an electric field across the substrate, or a portion thereof, bioanalytes from the sample are attracted to a conductor having a positive or negative charge, depending on the charges carried by the bioanalytes. The electric field can be created using two conductors in circuit with a power source, and the substrate may be positioned between the conductors.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: February 18, 2025
    Assignee: Revvity Health Sciences, Inc.
    Inventors: Michael Nilsson, Erhard Ralf Schoenbrunner
  • Patent number: 12228539
    Abstract: A method of analyzing a molecule is disclosed. A voltage source is selectively connected to or disconnected from a capacitor using a switch controlled by a reset signal. A charge is stored in a capacitor when the voltage source is connected to the capacitor. The capacitor is discharged through a nanopore in a membrane when the voltage source is disconnected from the capacitor. A duty cycle of the reset signal is determined such that the voltage source and the capacitor is connected for at least a one tenth portion of a reset signal period and disconnected for a remaining portion of the reset signal period, such that a voltage across the nanopore is maintained at a higher level during the portion of the reset signal period in which the connection is maintained than during the remaining portion of the reset signal period in which the connection is not maintained.
    Type: Grant
    Filed: September 7, 2021
    Date of Patent: February 18, 2025
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Roger J. A. Chen, J. William Maney, Jr., Hui Tian
  • Patent number: 12216081
    Abstract: A sample setting section in which at least one sample to be subjected to electrophoresis analysis and at least one standard sample are set, and a controller. The controller includes a standard data storage memory that stores standard data obtained by performing electrophoresis analysis of a standard sample under a predetermined condition, and a chip determination part configured to perform electrophoresis analysis of the standard sample under the predetermined condition using each of the at least one microchip before electrophoresis analysis of the sample set in the sample setting section is performed to acquire analysis data on the standard sample by the detector, and to perform a chip determination as to whether a state of each of the at least one microchip is suitable for performing electrophoresis analysis by comparing the acquired analysis data with the standard data on the standard sample.
    Type: Grant
    Filed: January 6, 2022
    Date of Patent: February 4, 2025
    Assignee: SHIMADZU CORPORATION
    Inventors: Akira Harada, Kota Ogino, Hidesato Kumagai
  • Patent number: 12203922
    Abstract: An electrochemical measurement apparatus includes: a tank containing electrolytic solution and a sample that generates or consumes measurement target substances in the electrolytic solution; a plurality of uniformly mixed working electrodes; and a counter electrode; the apparatus adapted to simultaneously apply a voltage between each of the working electrodes and the counter electrode; and the apparatus configured to measure a current that flows between each of the working electrodes and the counter electrode; wherein any two working electrode groups are mutually different in at least any of the determined voltage, presence/absence of a molecular modification of an electrode surface, and a species of the molecular modification; and whereby a distribution in measurement area of the currents that flow through the working electrodes is acquired.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: January 21, 2025
    Assignees: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITED
    Inventors: Kosuke Ino, Yusuke Kanno, Tomokazu Matsue, Kumi Inoue, Ryota Kunikata, Hiroyuki Hayashi, Atsushi Suda
  • Patent number: 12188893
    Abstract: An electrochemical sensor is provided which may be formed using micromachining techniques commonly used in the manufacture of integrated circuits. This is achieved by forming microcapillaries in a silicon substrate and forming an opening in an insulating layer to allow environmental gases to reach through to the top side of the substrate. A porous electrode is printed on the top side of the insulating layer such that the electrode is formed in the opening in the insulating layer. The sensor also comprises at least one additional electrode. The electrolyte is then formed on top of the electrodes. A cap is formed over the electrodes and electrolyte. This arrangement may easily be produced using micromachining techniques.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: January 7, 2025
    Assignee: Analog Devices International Unlimited Company
    Inventors: Alfonso Berduque, Helen Berney, William Allan Lane, Raymond J. Speer, Brendan Cawley, Donal McAuliffe, Patrick Martin McGuinness
  • Patent number: 12174139
    Abstract: A gas sensor control device having a DA conversion circuit configured to supply a pump current having a magnitude corresponding to an inputted digital signal to the pump cell, a reference electric potential generating circuit configured to keep an electric potential of the first pump electrode at a reference electric potential, a diagnostic resistance connected to the pump cell parallel to the pump cell, and an output part configured to output a signal relating to voltage applied to the diagnostic resistance when inputting an arbitrary digital signal to the DA conversion circuit in a situation in which oxygen ion conductivity does not occur in the pump cell to an external device.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: December 24, 2024
    Assignee: Niterra Co., Ltd.
    Inventors: Yuzo Higuchi, Koji Ishibashi, Junichiro Mitsuno, Satoru Abe, Yuji Oi
  • Patent number: 12174140
    Abstract: Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: December 24, 2024
    Assignee: President and Fellows of Harvard College
    Inventors: Donhee Ham, Hongkun Park, Keith Krenek, Tianyang Ye, Jeffrey T. Abbott, Wenxuan Wu
  • Patent number: 12168974
    Abstract: Provided are embodiments of a wind energy system. The system includes a plurality of wind turbines connected to at least one cable network. The cable network is configured to transmit the electrical power fed-in by the connected wind turbines. The system also includes at least one control apparatus configured to control the power fed into the cable network by at least one of the wind turbine by providing at least one power set point. At least one temperature detecting device is configured to detect the temperature of the cable network. At least one condition detecting device is configured to detect the condition of the wind energy system, and the control apparatus includes at least one control device configured to determine the power set point based on the detected temperature and the detected condition.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: December 17, 2024
    Assignee: innogy SE
    Inventors: Christian Feltes, Christian Jahn, Nils Thomsen, Jörn Runge
  • Patent number: 12157914
    Abstract: Disclosed are biosensor devices, systems, and methods for point-of-care applications.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: December 3, 2024
    Assignee: The Regents of the University of California
    Inventors: Drew Hall, Chung-Lun Hsu, Alexander Sun, Yunting Zhao, Eliah Aronoff-Spencer
  • Patent number: 12153011
    Abstract: A gas sensor has a sensor element, first element pads, second element pads, first contact-point members, and second contact-point members. The sensor element has first and second surfaces that are positioned on opposite sides in a first direction. The first element pads are disposed on the first surface. The second element pads are disposed on the second surface in a quantity greater than that of the first element pads. The first and second contact-point members are connected to the first and second element pads, respectively. The width (Wt) of at least one of the second contact-point members is less than the widths (Wa-Wd) of the rest of the first and second contact-point members.
    Type: Grant
    Filed: August 8, 2022
    Date of Patent: November 26, 2024
    Assignee: NGK INSULATORS, LTD.
    Inventors: Shotaro Niizuma, Yusuke Watanabe, Toshihiro Hirakawa, Hayami Aota
  • Patent number: 12140579
    Abstract: A controller of the gas sensor can perform diagnostic processing of diagnosing a situation of control to the gas sensor in a case that the gas sensor in an operation state is determined to satisfy a predetermined diagnostic condition and adjustment processing of adjusting a condition for controlling the gas sensor in accordance with a result of diagnosis. In the diagnostic processing, a main pump voltage and a diagnostic threshold as a value of a voltage not causing decomposition of NOx in the main pump cell are compared. In the adjustment processing, temperature adjustment processing to cause, in a case that the main pump voltage is diagnosed to be equal to the threshold or more, the main pump voltage to be less than the threshold, at least in a way that the heater part increases the element driving temperature in the operation state by a predetermined increase amount is performed.
    Type: Grant
    Filed: November 18, 2022
    Date of Patent: November 12, 2024
    Assignee: NGK INSULATORS, LTD.
    Inventors: Yusuke Watanabe, Takayuki Sekiya, Daichi Ichikawa
  • Patent number: 12140558
    Abstract: A bio sensor using a FET element and an extended gate, and an operating method thereof are disclosed. A biosensor using a field effect transistor (FET) device and an extended gate electrode according to the present invention is characterized by comprising: an extended gate electrode connected to the FET element; a sensing electrode made of the same material as the extended gate electrode and on which a receptor antibody selectively recognizing a target molecule is fixed; and a reference electrode that maintains a constant potential and is selectively connected to the sensing electrode.
    Type: Grant
    Filed: December 31, 2020
    Date of Patent: November 12, 2024
    Assignee: KOREA ELECTRONICS TECHNOLOGY INSTITUTE
    Inventors: Kook Nyung Lee, Woo Kyeong Seong, Won Hyo Kim
  • Patent number: 12111281
    Abstract: An illustrative example hydrogen concentration sensor includes a hydrogen chamber configured to isolate hydrogen within the hydrogen chamber from gas outside the hydrogen chamber. A hydrogen evolving electrode is configured to generate pure hydrogen within the hydrogen chamber. A reference electrode is situated to be exposed to pure hydrogen within the hydrogen chamber. A detection electrode associated with the reference electrode is situated to be exposed to gas outside the hydrogen chamber. The detection electrode is configured to provide an indication of a concentration of hydrogen in the gas outside the hydrogen chamber.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: October 8, 2024
    Assignee: HYAXIOM, INC.
    Inventors: Joshua Preston, Timothy William Patterson, Jr.
  • Patent number: 12105080
    Abstract: An electrochemical measurement apparatus includes: a tank containing electrolytic solution and a sample that generates or consumes measurement target substances in the electrolytic solution; a plurality of uniformly mixed working electrodes; and a counter electrode; the apparatus adapted to simultaneously apply a voltage between each of the working electrodes and the counter electrode; and the apparatus configured to measure a current that flows between each of the working electrodes and the counter electrode; wherein any two working electrode groups are mutually different in at least any of the determined voltage, presence/absence of a molecular modification of an electrode surface, and a species of the molecular modification; and whereby a distribution in measurement area of the currents that flow through the working electrodes is acquired.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: October 1, 2024
    Assignees: TOHOKU UNIVERSITY, JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITED
    Inventors: Kosuke Ino, Yusuke Kanno, Tomokazu Matsue, Kumi Inoue, Ryota Kunikata, Hiroyuki Hayashi, Atsushi Suda
  • Patent number: 12099032
    Abstract: An electrophoresis cartridge can include an integrated electrophoresis assembly including an anode sub-assembly comprising an anode, a cathode sub-assembly comprising a cathode; and at least one electrophoresis capillary having a first end in fluid communication with the cathode sub-assembly and a second end in fluid communication with the anode sub-assembly. The cartridge can further include a reagent container comprising electrophoresis buffer; a fluid conduit in fluidic communication with the reagent container; a pump in fluidic communication with the fluid conduit, the pump configured to transfer the electrophoresis buffer through the fluid conduit from the reagent container to the passage of the cathode sub-assembly; and a sample inlet port and at least one sample line, wherein the sample line places the sample inlet port in fluidic communication with the first end of the electrophoresis capillary through a passage in the cathode sub-assembly.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: September 24, 2024
    Assignee: INTEGENX, INC.
    Inventors: Alexander Kindwall, Chungsoo Charles Park, Fedor IIkov, Stevan Jovanovich, David King, Tristan Robert Littlehale, David Grant Nilson, Rick Pittaro, Robert A. Schueren, Mattias Vangbo, Philip Justus Wunderle
  • Patent number: 12099030
    Abstract: A gas sensor capable of detecting carbon dioxide and having high stability is provided. A carbon dioxide gas sensor comprising an insulating substrate 3 and a gas sensing layer 1 formed on one major surface of the insulating substrate 3 via electrodes 2, wherein the gas sensing layer 1 comprises: (a) one or more rare earth metal oxycarbonates represented by Ln2O2CO3, Ln being at least one rare earth metal element selected from Sc, Y, La, Ce, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Pr, Yb and Lu, the rare earth metal oxycarbonate containing a hexagonal rare earth metal oxycarbonate as a main component; or (b) monoclinic samarium dioxycarbonate, a production method of the gas sensor, and a method of selectively producing crystal polymorphism of lanthanum dioxycarbonate represented by La2O2CO3 are provided.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: September 24, 2024
    Assignee: FUJI ELECTRIC CO., LTD.
    Inventor: Takuya Suzuki
  • Patent number: 12085559
    Abstract: A plenum assembly configured for electrophysiology assays, such as patch clamp techniques, includes one or more ground electrode assemblies. The ground electrode assemblies are individually removable from a plenum base of the plenum assembly in a non-destructive manner, and may be reinstalled in the plenum base in a manner that reestablishes electrical contact with ground circuitry without requiring soldering or other additional steps. A rejuvenating apparatus is provided for rejuvenating one or more ground electrode assemblies removed from the plenum base.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: September 10, 2024
    Assignee: Molecular Devices, LLC
    Inventors: Thomas L. Smith, Edward Verdonk
  • Patent number: 12083490
    Abstract: According to an aspect of the disclosure, there is provided a microwave reactor including a container for storing a bath fluid, a tube including an inlet at one end through which a target fluid is introduced, an outlet at another end through which the target fluid is discharged, wherein at least a portion of the tube is submerged in the bath fluid, and at least one radiator located outside the container and configured to irradiate microwaves into the container.
    Type: Grant
    Filed: February 1, 2022
    Date of Patent: September 10, 2024
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Taejung Kim, Jungyeob Ham, Young Tae Park, Pilju Choi, Joonyeon Chang
  • Patent number: 12078609
    Abstract: A system for measuring a variable of a liquid and a method operation the system is disclosed. The system comprises: a sensor located on an end section of an elongated sensor support and embodied to measure the variable; a containment device that is open at the top; the containment device including: a bottom section given by a liquid impermeable retainment basin, a top section having a side wall surrounding an interior of the top section and apertures extending through the side wall of the top section; and fasteners embodied to at a measurement site mount the sensor support in a fixed sensor support position in relation to a fixed device position of the containment device such that the sensor is located inside the retainment basin.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: September 3, 2024
    Assignee: Endress+Hauser Inc.
    Inventor: Fred Kohlmann
  • Patent number: 12072328
    Abstract: Provided is a coreflood apparatus that comprises a housing, an inlet, an outlet, and two chambers positioned within the housing that are configured to retain porous media. The apparatus includes a partition coupled to an inner surface of the housing between the two chambers and a sensor mounting location. Provided is a method of introducing a fluid into the coreflood apparatus and allowing fluid to pass through chambers in the apparatus having a sensor mounting location there between. Further provided is a coreflood system comprising a coreflood apparatus, a calcium ion sensor, and a data processing device. Provided is a method of introducing fluid into the coreflood system and allowing fluid to pass through chambers in the system having a calcium ion sensor there between. The method further comprises detecting calcium ions in the fluid and determining calcium ion concentration data.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: August 27, 2024
    Assignee: SAUDI ARABIAN OIL COMPANY
    Inventors: Mohammed Badri Al-Otaibi, Dong Kyu Cha