Abstract: The invention provides for novel (bis)urea and (bis)thiourea compounds which are inhibitors of lysine-specific demethylase 1 (LSD1). Such compounds may be used to treat disorders, including cancer.
Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
Type:
Grant
Filed:
January 2, 2003
Date of Patent:
November 5, 2013
Assignee:
Versi Group, LLC
Inventors:
Kwen-Jen Chang, Klim King, Kestutis P. Biciunas, Robert W. McNutt, Jr., William Pendergast, Shyi-Tai Jan
Abstract: This invention relates to the interconversion of inactive 11-keto steroids with their active 11B-hydroxy equivalents, to methods by which the conversion of the inactive to the active form may be controlled, and to useful therapeutic effects which may be obtained as a result of such control. More specifically, but not exclusively, the invention is concerned with interconversion between cortisone and cortisol in humans.
Type:
Grant
Filed:
February 22, 2002
Date of Patent:
October 17, 2006
Assignee:
The University of Edinburgh
Inventors:
Brian Robert Walker, Christopher Richard Watkin Edwards, Jonathan Robert Seckl