Abstract: The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart conditions, cardiac arrhythmias, hypertensive crisis in an emergency room setting, hypertension before, during, or after surgery, no-reflow phenomenon following reperfusion, and diseases associated with decreased skeletal muscle blood flow. The invention also relates to pharmaceutical compositions formulated for use in such methods and to kits for such methods.
Type:
Grant
Filed:
July 18, 2017
Date of Patent:
July 3, 2018
Assignee:
Milestone Pharmaceuticals Inc.
Inventors:
Martin P. Maguire, Elise Rioux, Harry J. Leighton
Abstract: The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart conditions, cardiac arrhythmias, hypertensive crisis in an emergency room setting, hypertension before, during, or after surgery, no-reflow phenomenon following reperfusion, and diseases associated with decreased skeletal muscle blood flow. The invention also relates to pharmaceutical compositions formulated for use in such methods and to kits for such methods.
Type:
Grant
Filed:
July 20, 2017
Date of Patent:
July 3, 2018
Assignee:
Milestone Pharmaceuticals Inc.
Inventors:
Martin P. Maguire, Elise Rioux, Harry J. Leighton
Abstract: 8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) has an action to promote synthesis and regeneration of elastin, and is useful as an agent for the prophylaxis or improvement of wrinkles, and an anti-aging drug.
Type:
Grant
Filed:
April 4, 2014
Date of Patent:
June 5, 2018
Assignee:
Nishizaki Bioinformation Research Institute
Abstract: Compositions containing conjugates of heparosan polymer with at least one drug are disclosed, along with methods of production and use thereof.
Type:
Grant
Filed:
November 7, 2014
Date of Patent:
March 27, 2018
Assignee:
THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
Abstract: Disclosed is a pharmaceutical composition comprising a complex between solifenacin or a pharmaceutically acceptable salt thereof and an ion exchange resin, and an acrylic based polymer.
Abstract: It has been discovered that inhibiting mitochondrial respiration in platelets reduces platelet activation or platelet aggregation. Certain heterocyclic compounds significantly reduced one or more platelet functions including clumping, sticking or platelet-stimulated clotting. Thus diseases or disorders mediated by inappropriately high levels of platelet activation or platelet aggregation can be treated by administering a therapeutically effective amount of a heterocyclic compound or nonheterocyclic mitochondrial inhibitor that significantly reduces one or more platelet functions including clumping, sticking or platelet-stimulated clotting, preferably in a reversible manner.
Type:
Grant
Filed:
April 25, 2011
Date of Patent:
March 20, 2018
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
James P. Collman, Paul Clifford Herrmann, David Alvin Tyvoll, Richard Decreau, Brian Stanley Bull, Christopher Jeffrey Barile
Abstract: Manufactured hyaluronic acid products are used in numerous surgical applications including viscoelastic supplementation for the treatment of osteoarthritis, however, traditional sterilization techniques result in the breakdown of such high molecular o weight viscoelastic biopolymers and are thus unsuitable. Disclosed are processes for obtaining concentrated sterile solutions of high molecular weight biopolymers such as hyaluronic acid. The processes include filter sterilization with a dilute preparation of the biopolymer, and concentration of the dilute filter sterilized biopolymer by ultrafiltration to a desired concentration.
Abstract: Nasal pharmaceutical formulations comprising a drug substance having a specific particle size distribution profile are disclosed herein. Such profile provides increased bioavailability, increased efficacy or prolonged therapeutic effect of the drug substance when administered intranasally. The formulations of the present invention may comprise one or more corticosteroids having a specific particle size distribution profile. In a preferred embodiment, the corticosteroid is fluticasone or a pharmaceutically acceptable derivative thereof for the treatment of one or more symptoms of rhinitis. Preferably, the drug substance is fluticasone propionate. The formulations herein may be provided as an aqueous suspension suitable for inhalation via the intranasal route.
Abstract: A method for treating abnormal ?-amyloid mediated diseases is disclosed, comprising administering a pharmaceutical composition to a subject in need, wherein the pharmaceutical composition comprises an indolylquinoline derivative represented by the following formula 1:
Type:
Grant
Filed:
May 12, 2015
Date of Patent:
October 24, 2017
Assignee:
NATIONAL TAIWAN NORMAL UNIVERSITY
Inventors:
Guey-Jen Lee-Chen, Hsiu-Mei Hsieh, Ching-Fa Yao
Abstract: The invention provides water-soluble oligomer-beta blocker drug conjugates. A drug conjugate of the invention can be administered by any of a number of administration routes and exhibits properties that are different from the corresponding beta blocker not attached to the water-soluble oligomer.
Type:
Grant
Filed:
March 12, 2008
Date of Patent:
October 10, 2017
Assignee:
Nektar Therapeutics
Inventors:
Jennifer Riggs-Sauthier, Franco J. Duarte
Abstract: The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart conditions, cardiac arrhythmias, hypertensive crisis in an emergency room setting, hypertension before, during, or after surgery, no-reflow phenomenon following reperfusion, and diseases associated with decreased skeletal muscle blood flow. The invention also relates to pharmaceutical compositions formulated for use in such methods and to kits for such methods.
Type:
Grant
Filed:
September 12, 2016
Date of Patent:
August 22, 2017
Assignee:
Milestone Pharmaceuticals Inc.
Inventors:
Martin P. Maguire, Elise Rioux, Harry J. Leighton
Abstract: A one part, solids containing decontamination blend composition comprises a solid acetyl donor coated with a compound that protects it from hydrolysis, a peroxygen source, optionally a catalyst, optionally a surfactant, and optionally a buffer. The decontamination blend composition is generally in a dry powder, particle, etc. form or in a tablet, pill, etc. form and is complete in and of itself in that no additional compounds are required prior to use and is readily distributed as a one package system. Upon the addition of water, a peroxygen compound such as hydrogen peroxide is formed, and peracetic acid is generated under alkaline conditions. The decontamination blend composition is particularly suitable for oxidizing various chemical and biological compounds thereby eradicating the same in situ as on surfaces, clothes, articles, and the like. Representative contaminants include mustard gas, nerve gas, bacterial toxins, anthrax, bird flu, and the like.
Type:
Grant
Filed:
August 15, 2006
Date of Patent:
August 8, 2017
Assignees:
American Sterilizer Company, The United States of America as represented by the Secretary of the Army
Inventors:
Herbert J. Kaiser, Anchalee Thanavaro, Brandon W. Dell'Aringa, Bryan M. Tienes, Daniel A. Klein, George W. Wagner
Abstract: A one part, solids containing decontamination blend composition comprises a solid acetyl donor coated with a compound that protects it from hydrolysis, a peroxygen source, optionally a catalyst, optionally a surfactant, and optionally a buffer. The decontamination blend composition is generally in a dry powder, particle, etc form or in a tablet, pill, etc form and is complete in and of itself in that no additional compounds are required prior to use and is readily distributed as a one package system. Upon the addition of water, a peroxygen compound such as hydrogen peroxide is formed, and peracetic acid is generated under alkaline conditions. The decontamination blend composition is particularly suitable for oxidizing various chemical and biological compounds thereby eradicating the same in situ as on surfaces, clothes, articles, and the like. Representative contaminants include mustard gas, nerve gas, bacterial toxins, anthrax, bird flu, and the like.
Type:
Grant
Filed:
July 24, 2007
Date of Patent:
July 11, 2017
Assignees:
American Sterilizer Company, The United States of America as Reresented by the Secretary of the Army
Inventors:
Herbert J. Kaiser, Anchalee Thanavaro, Brandon W. Dell'Aringa, Bryan M. Tienes, Daniel A. Klein, George W. Wagner
Abstract: Compositions and methods for treatment of Parkinson's disease to reduce the negative side effects of the disease by administering a therapeutically effective diarylmethylpiperazine compound which exhibits delta opioid receptor agonist activity, and optionally, mu receptor antagonist activity.
Type:
Grant
Filed:
February 3, 2014
Date of Patent:
July 11, 2017
Assignee:
VERSI GROUP, LLC
Inventors:
Kwen-Jen Chang, William Pendergast, Jonathon D. S. Holt
Abstract: The present invention includes compositions, methods, and systems for the development and use of heparosan, a natural polymer related to heparin, as a new therapeutic modifying agent or vehicle which can modulate drug cargo pharmacokinetics and behavior within a mammalian patient.
Type:
Grant
Filed:
September 9, 2009
Date of Patent:
June 27, 2017
Assignee:
The Board of Regents of the University of Oklahoma
Abstract: A method of improving cognitive function or treating cognitive dysfunction is provided. The method is based on activating a kainate receptor or a glutamate GluR6 receptor by kainate or a glutamate GluR6 receptor activator such as an agonist. Additionally, a method of enhancing a learning ability by activating a kainate receptor such as the glutamate GluR6 receptor via kainate or a glutamate GluR6 receptor activator such as an agonist is provided.
Abstract: The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels of MIF expression.
Type:
Grant
Filed:
May 4, 2010
Date of Patent:
May 9, 2017
Assignee:
Yale University
Inventors:
William L. Jorgensen, Richard J. Bucala
Abstract: A method of treating and/or preventing Dravet Syndrome in a patient such as a patient previously diagnosed with Dravet Syndrome, by administering an effective dose of fenfluramine or its pharmaceutically acceptable salt to that patient. Dravet Syndrome patients are typically children under the age of 18 and are treated at a preferred dose of less than about 0.5 to about 0.01 mg/kg/day.
Type:
Grant
Filed:
July 30, 2014
Date of Patent:
April 4, 2017
Assignees:
The Katholieke Universiteit Leuven, University Hospital Antwerp