Abstract: The disclosure relates to a centrifuge with a balancing mechanism and method of balancing such a centrifuge. The centrifuge includes a vertical shaft driven in rotation by a motor, and a mechanism for balancing the parts integral with said vertical shaft. The mechanism includes a plate integral with the vertical shaft, at least one compensating mass freely displacing on the plate, the mass being designed to limit the imbalance of parts integral with the vertical shaft, and a mechanism for blocking the compensating mass, the blocking mechanism being designed to immobilize the compensating mass on the plate when the rotation speed exceeds a determined value.
Type:
Grant
Filed:
October 16, 2014
Date of Patent:
August 21, 2018
Assignee:
Macopharma SAS
Inventors:
Jean-Claude Letourneur, Philippe Le Guyader, Franck Boucard
Abstract: The present disclosure relates to a centrifugal separator (1), which comprises a rotatable drum (5) having a wall (50), an annular chamber (7), defined along the longitudinal axis (49) of the rotatable drum (5) and bordering the wall (50), an annular screw feeder (90) accommodated rotatably in the annular chamber (7) for moving a mixture of substances in the liquid phase and in the solid phase longitudinally through the annular chamber (7), and separation nets (100) arranged in the wall (50) of the rotatable drum (5). The separation nets (100) have meshes for filtering the solid phase from the liquid phase by rotation of the drum (5). The separation nets (100) are movable relative to the wall (50).
Type:
Grant
Filed:
October 2, 2013
Date of Patent:
August 21, 2018
Assignee:
Mantovani & Vicentini S.R.L
Inventors:
Leonardo Renzo Vicentini, Albert Walraven
Abstract: The invention relates to an elutriation chamber for an elutriator system for washing and/or isolating cells, in particular thrombocytes, which elutriation chamber comprises a feed line (1) for an aqueous medium containing the cells to be washed and/or to be isolated in suspended form, and a discharge line (2) for the washed and/or isolated cells, wherein the chamber (5) is rotationally symmetrical to the axis (a), characterized in that the ratio of the area of the section through the lumen of the chamber (5) perpendicular to the axis (a) at the widest point (5a-5b) to the area of the section (1a) through the feed line (1) is in the range of 1,000 to 250,000.
Type:
Grant
Filed:
May 13, 2013
Date of Patent:
August 14, 2018
Assignee:
BIO-PRODUCTS & BIO-ENGINEERING AG
Inventors:
Johann Eibl, Johann Graus, Christoph Mader
Abstract: A system for cleaning polluted scrubber fluid includes a disc stack centrifugal separator a separator inlet for polluted scrubber fluid, a first separator outlet for cleaned scrubber fluid, and a second separator outlet for a pollutant phase. A first transportation system transports polluted scrubber fluid to the separator inlet, a second transportation system transports cleaned scrubber fluid back to the exhaust gas scrubber, a bleed-off transportation system connected to the second transportation system bleeds off part of the cleaned scrubber fluid, a dirty drain tank connected to the bleed-off transportation system receives the bled-off scrubber fluid, and a waste reduction transportation system transports scrubber fluid from the dirty drain tank to the first transportation system. A controller receives information related to the work load of the disc stack centrifugal separator and regulates the transport of scrubber fluid based on the information.
Abstract: A sample container cap is disclosed. The sample cap container includes a sample cap body capable of covering an opening of a sample container and a centrifugation status indicator device in the top of the sample cap body. The centrifugation status indicator device includes: a first substance having a first density and a first color, and a second substance having a second density and a second color. The centrifugation status indicator device displays the first substance when the sample container has been centrifuged. The first substance can be a gel, and the second substance can include a plurality of particles. The second density is higher than the first density and the second color is different from the first color.
Type:
Grant
Filed:
April 29, 2015
Date of Patent:
August 14, 2018
Assignee:
Beckman Coulter, Inc.
Inventors:
Martin Müller, Andreas Weihs, Gerhard Gunzer, Michael Eberhardt
Abstract: A cleaning in place system for a centrifugal separator and a method of cleaning a centrifugal separator are disclosed. The centrifugal separator includes a rotor having a separation space, a separator inlet and a first separator outlet. The first separator outlet includes an outlet pump configured to provide a flow of fluid from the first separator outlet. The cleaning in place system further includes a container for cleaning fluid, a cleaning fluid pump for providing cleaning fluid from the container to the separator inlet, such as an eductor. The cleaning in place system is configured to receive a flow of fluid from the first separator outlet and that the cleaning fluid pump is configured to pump cleaning fluid from the container to the separator inlet by means of the received flow of fluid.
Abstract: A system for removing undesirable elements from blood. The system includes a centrifuge bowl to separate the blood into components according to relative densities of the components, a pump to provide wash solution that washes the blood in the centrifuge bowl, and a controller to wash the blood in the centrifuge bowl in a first wash and remove first undesirable elements and to wash the blood in the centrifuge bowl in a second wash and remove trapped undesirable elements. The controller to further mix the blood and the wash solution in the centrifuge bowl and provide diluted blood, separate the diluted blood into concentrated blood and the wash solution, fill the centrifuge bowl with previously concentrated blood to build a buffy coat, and empty the centrifuge bowl of the concentrated blood and the previously concentrated blood after the buffy coat is reached.
Abstract: A method is provided for clarifying a flowable starting product with a separator having a feed and at least one liquid discharge for continuously discharging at least one clarified liquid phase—a clear phase—and with discontinuously openable solid-discharge openings for discontinuously discharging the solid phase. The method involves the steps: a. setting or determining a starting time; b. repeatedly determining at least one actual value of a product-parameter of the clear phase derived from the drum; c. determining the time interval until the product-parameter actual value reaches or exceeds a product-parameter limit value; d. preferably initiating a solid discharge as a result of reaching or exceeding the product-parameter limit value; e. determining and setting an operating time interval by using the determined calibrating time interval, the operating time interval being less than or greater than the ascertained calibrating time interval; and f.
Type:
Grant
Filed:
October 20, 2014
Date of Patent:
August 7, 2018
Assignee:
GEA MECHANICAL EQUIPMENT GMBH
Inventors:
Wilfried Mackel, Markus Fleuter, Josef Linckamp
Abstract: A method for lowering the pressure inside the hood interior of a separator arrangement with a separator with a rotatable drum includes rotating the rotatable drum about a vertical rotation axis. Before processing a product that is to be processed, a liquid is first directed through the drum and the pressure inside the hood interior is lowered, by a device, as a result of rotations of the drum in the manner of a jet pump. After the pressure inside the hood interior has been lowered sufficiently, then the actual processing of the product that is to be processed is performed.
Abstract: Centrifuge vessels suitable for live cell processing include a bowl with a cap, and a tube inside the bowl extending between the cap and a lower portion of the bowl. The bottom of the bowl can have a closed annular ring surrounding a center mound. The vessels can be particularly suitable for processing low volumes of live cells for vaccines or other therapies.
Type:
Grant
Filed:
January 22, 2013
Date of Patent:
July 17, 2018
Assignee:
Argos Therapeutics, Inc.
Inventors:
Tamara Tatroe Monesmith, Arjun V. Caprihan, Christopher Thomas Ryan, Richard A. Grant, Ian S. Fitzpatrick, Christopher John Leigh-Lancaster
Abstract: A method is provided for continuously clarifying a flowable suspension with a discontinuously solid-discharging—self-discharging—separator, which has a rotatable drum with a vertical axis of rotation, a feed for the suspension to be clarified and at least one liquid discharge for continuously discharging at least one clarified liquid phase, and discontinuously openable solid-discharge openings for discontinuously discharging the solid phase. The method involves a) measuring one or more of the suspension parameters mass, mass of solid substance in the suspension, mass flow, temperature, density, cumulative density; and b) initiating a time-limited discharge of solid substance as a result of a repeated determination on the basis of step a) in the event of or after the exceeding of a limit value.
Abstract: A rotating machine has a bowl that is rotatable about an axis to generate a cylindrical pool of a feed slurry. The bowl has a heavy phase discharge port and a base plate at one longitudinal end of the bowl. There is at least one outlet opening in the base plate and a liquid phase discharge port member positioned over the outlet opening. The liquid phase discharge port member includes at least one open straight channel having a longitudinal axis that extends at an acute angle relative to the base plate. The channel has an extension in the direction of the longitudinal axis of open straight channel.
Abstract: A centrifuge including: a rotor configured to hold a sample and configured to be detachably mounted, a rotation chamber accommodating the rotor, a plurality of motors configured to be rotationally driven by three-phase AC power, and a control device configured to control centrifuging operation, wherein one of the plurality of motors is a centrifuge motor configured to rotate the rotor, and the control device is configured to change distribution of power supplied to the centrifuge motor and power supplied to another motor of the plurality of motors during one operation.
Abstract: A centrifugal separator for separating a fluid mixture into components, including a non-rotating part, a rotor which is attached to a shaft which is rotatably supported in the non-rotating part around a rotational axis, which rotor forms within itself a separation space delimited by a rotor wall. The separator includes an inlet extending into the rotor for supply of a fluid mixture to be separated in the separation space, at least one sensor measuring unbalance conditions in the frame; a level determining arrangement including two or more space defining elements of arbitrary form arranged on the interior surface of, or close to, the rotor wall, where each space defining element defines a space which communicates with the separation space or another of the space defining elements through at least one inlet opening arranged at a certain radius from the rotational axis and not outside that radius and where that certain radii of the space defining elements are different.
Type:
Grant
Filed:
May 27, 2014
Date of Patent:
May 22, 2018
Assignee:
ALFA LAVAL CORPORATE AB
Inventors:
Lars Hillström, Hans Moberg, Finn Rundström, Peter Thorwid, Roland Isaksson, Jan Skoog
Abstract: Disclosed herein are instruments and methods for performing both sample homogenization and sample clarification by centrifugation with a single instrument without transferring the sample to a new sample container and without removing or repositioning the sample container within the instrument. In some embodiments, the instrument may automatically perform centrifugation after homogenization. In other embodiments, the instrument may perform both homogenization and centrifugation simultaneously.
Abstract: According to one exemplary embodiment of the present invention, a method of centrifuging a mixture using a syringe which has a nozzle at one end, comprises the steps of taking the mixture in the syringe, first centrifuging the mixture in the syringe, discharging one part of the mixture which is adjacent to the nozzle after the first centrifuging, second centrifuging the mixture in the syringe after reversing the syringe, and discharging another part of the mixture which is adjacent to the nozzle after the second centrifuging.
Type:
Grant
Filed:
October 12, 2011
Date of Patent:
May 1, 2018
Assignee:
SNU R&DB FOUNDATION
Inventors:
Chris Hyunchul Jo, Sue Shin, Kang Sup Yoon
Abstract: A centrifugal separator includes a frame and a rotating part including a spindle and a centrifuge rotor enclosing a separation space. An inlet channel provides fluid communication into the separation space and includes a rotary channel part, a frame channel part, and a first seal at the interface between the rotary and frame channel parts. An outlet channel provides fluid communication out from the separation space and includes a rotary channel part, a frame channel part, and a second seal at the interface between the rotary and frame channel parts. The inlet and outlet channels are arranged concentrically with each other. A forcing device is provided to generate a leak flow through one of the first and second seals in a first direction from the outlet channel to the inlet channel and to counteract leakage in the opposite direction.
Abstract: A collection apparatus for a separator. The collection apparatus including a housing at least partially encircling a flow separation passage and defining a chamber and a cutout, the chamber being in fluid communication with the flow separation passage to receive a separated flow therefrom, and the cutout extending outward from the chamber to at least partially deflect the separated flow.
Abstract: A centrifuge, in particular a separator, includes a rotatable centrifuge drum with a vertical axis of rotation and a non-rotatable fixed housing with a hood and preferably a solids collector. In the centrifuge, the housing, in particular the fixed hood and/or at least one other part of the housing, have at least one first inner wall and a first outer wall which delimit a first cavity. The cavity is at least partly filled with damping/insulation agents that are solid at a process or ambient temperature. A coolant that has a fluid form at a process and/or ambient temperature can be introduced into the first cavity filled with the solid damping/insulation agents.
Type:
Grant
Filed:
July 2, 2012
Date of Patent:
December 19, 2017
Assignee:
GEA Mechanical Equipment GmbH
Inventors:
Wilfried Mackel, Andreas Penkl, Thomas Bathelt, Reinhard Moss
Abstract: Sterilizable separator tubes and methods of utilization of same are presented. Methods include providing a separator tube containing a separator substance that can be polymerized to a desired hardness following sterilization using radical generating radiation. The separator substance is formulated to have a density between that of the average densities of separable fractions derived from a sample fluid such as blood, and to be flowable. Upon centrifugation of a separator tube containing a fluid sample, the separator substance forms a barrier between the fractions. The barrier subsequently hardens to form a solid barrier when triggered by a suitable energy source.
Type:
Grant
Filed:
October 22, 2012
Date of Patent:
June 6, 2017
Assignee:
The Regents Of The University of California