Patents Examined by Sikarl A. Witherspoon
  • Rhenium catalysts for glycerin to allyl alcohol conversion
    Patent number: 10919024
    Abstract: A catalyst system for the conversion of glycerin to allyl alcohol, the catalyst system comprising: a rhenium compound selected from rhenium dioxide, rhenium trioxide, and a combination thereof. A method of producing allyl alcohol from glycerin via the catalyst system, the method comprising exposing glycerin to a temperature of greater than 140° C. in the presence of a catalyst comprising rhenium trioxide, rhenium dioxide, or a combination thereof to produce a product comprising allyl alcohol.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: February 16, 2021
    Assignee: Lyondell Chemical Technology, L.P.
    Inventors: Xueyong Yang, Daniel F. White, Beaven S. Mandimutsira
  • Online continuous flow process for the preparation of organic peroxides direct from alcohols or alkanes
    Patent number: 10919849
    Abstract: A continuous flow production process for preparing organic peroxides directly from alcohols or alkanes takes very safe alcohols or alkanes as starting materials, and directly reacts to obtain designated peroxides. The production process is carried out in an integrated continuous flow reactor, and a safe starting source of alcohol or alkane is continuously added at the feed inlet of the integrated continuous flow reactor, and continuously provided with a designated peroxide at the discharge port of the integrated continuous flow reactor.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: February 16, 2021
    Assignee: SHANGHAI HYBRID-CHEM TECHNOLOGIES
    Inventors: Bing Ma, Shuai Pan, Xinlin Shu
  • Combinations with 2-aminoethanesulfonic acid
    Patent number: 10918612
    Abstract: The invention relates to a pharmaceutical combination of 2-aminoethanesulfonic acid with a pharmaceutical agent such as an antihypertensive agent and the use of 2-aminoethanesulfonic acid in a method to lower the bilirubin level in the blood.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: February 16, 2021
    Inventor: Markus Zwickl
  • Producing BDO via hydroformylation of allyl alcohol made from glycerin
    Patent number: 10919023
    Abstract: A method including hydroformylating, with syngas, allyl alcohol in an allyl alcohol feed, to produce a hydroformylation product comprising 4-hydroxybutyraldehyde and 3-hydroxy-2-methylpropionaldehyde; and producing a 1,4-butanediol (BDO) product comprising BDO and 1,3-methylpropanediol via hydrogenation of at least a portion of the hydroformylation product. A method including hydroformylating, with syngas, allyl alcohol in a feed comprising bio-allyl alcohol, to produce a hydroformylation product comprising 4-hydroxybutyraldehyde and 3-hydroxy-2-methylpropionaldehyde; and producing a BDO product comprising BDO and 1,3-methylpropanediol via hydrogenation of at least a portion of the hydroformylation product.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: February 16, 2021
    Assignee: Lyondell Chemical Technology, L.P.
    Inventors: Xueyong Yang, Daniel F. White, Beaven S. Mandimutsira
  • Process for reducing 3,3,3-trifluoropropyne in 2,3,3,3-tetrafluoropropene
    Patent number: 10913697
    Abstract: The invention relates to a process for reducing the concentration of a fluorinated alkyne impurity, such as 3,3,3-trifluoropropyne (TFPY), in 2,3,3,3-tetrafluoropropene (HFO-1234yf) which comprises contacting such a mixture with a caustic material, such as sodium hydroxide (NaOH), under conditions effective to reduce the concentration of the fluorinated alkyne impurity, including in some practices reducing the concentration by at least about 50%.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: February 9, 2021
    Assignee: Honeywell International Inc.
    Inventors: Haiyou Wang, Hsueh Sung Tung, Willie Josue Perez, Yian Zhai, Ralph John Borowski, Fang Huang Tu, Lucas Peter Labuda, John L. Welch
  • Method for producing dimethylolbutanal and distillation apparatus for producing same
    Patent number: 10913700
    Abstract: A method for producing dimethylolbutanal, the method including: (A) distilling a raw material comprising dimethylolbutanal (DMB) in a distillation column; (B) separating the distilled raw material in the distillation column into a low boiling point component, dimethylolbutanal, and a high boiling point component; and (C) refluxing a portion or all of the high boiling point component to the distillation column by heating the portion or all of the high boiling point component, in which the dimethylolbutanal is separated from a side cut of the distillation column.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: February 9, 2021
    Assignee: LG CHEM, LTD.
    Inventors: Sungshik Eom, Dawon Jung, Tae Youn Kim, Dong Hyun Ko, Mi Young Kim, Min Ji Choi, Taewoo Kim
  • Process for the catalytic decarboxylative cross-ketonization of aryl and aliphatic carboxylic acid
    Patent number: 10906857
    Abstract: The present invention pertains to a process for the cross-ketonization (Piria reaction) between an aryl carboxylic acid and an aliphatic carboxylic acid using a metal-based compound and a slight or a moderate excess of aryl carboxylic acid. A good selectivity, up to 99 mol %, can be achieved. The aryl aliphatic ketone can be used for the preparation of surfactants and other downstream products.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: February 2, 2021
    Assignee: RHODIA OPERATIONS
    Inventors: Olivier Back, Philippe Marion
  • Orally administrable modified-release pharmaceutical dosage form
    Patent number: 10905667
    Abstract: The present invention relates to orally administrable modified-release pharmaceutical dosage forms comprising sodium (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate and to processes for preparing the dosage forms and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiac, renal and pulmonary disorders, disorders of the central nervous system, fibrotic and inflammatory disorders and metabolic disorders.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: February 2, 2021
    Assignees: BAYER PHARMA AKTIENGESELLSCHAFT, BAYER AKTIENGESELLSCHAFT
    Inventors: Anke Stroyer, Carmen Lobback, Peter Serno, Philipp Rubenbauer, Kai Lovis, Heiko Schirmer, Danja Grossbach, Donald Bierer, Britta Olenik, Tia Jacobs, Julia Küsel
  • Compositions and methods for treatment of pre-cancerous skin lesions
    Patent number: 10905763
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: February 2, 2021
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan
  • Adsorbing material for multiple pathogenic factors of sepsis as well as preparation method and application thereof
    Patent number: 10898632
    Abstract: An adsorbing material for multiple pathogenic factors of sepsis as well as a preparation method and an application thereof are provided. The adsorbing material is formed by coupling a carrier with good mechanical performance and blood compatibility and a ligand with the capacity to adsorb multiple pathogen-associated molecular patterns, and is capable of effectively adsorbing bacterial endotoxin, bacterial genomic DNA, peptidoglycan, lipoteichoic acid, virus RNA, and zymosan from fluids such as blood and the like, and in particular has application value in blood purification for treatment of sepsis.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: January 26, 2021
    Assignee: Chongqing Zhengbo Biotechnology Co. Ltd.
    Inventors: Yue Zheng, Jun Deng, Qingguang Liu
  • Dehydrogenation reaction
    Patent number: 10899694
    Abstract: The present invention relates to the field of organic synthesis and more specifically it concerns a process for the dehydrogenation of compound of formula (I) catalyzed by palladium (Pd0) in elemental metallic form.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: January 26, 2021
    Assignee: Firmenich SA
    Inventors: Denis Jacoby, Jean-Jacques Riedhauser, Philippe Miranda, Harvey Randall, Fabrice Keller
  • Process for the production of alkanesulfonic acids
    Patent number: 10894766
    Abstract: The present invention deals with a process for the production of alkanesulfonic acids, in particular methanesulfonic acid, and a method of purification of the raw products.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: January 19, 2021
    Assignee: BASF SE
    Inventors: Jan Spielmann, Juergen Wortmann, Frieder Borgmeier, Michael Zeilinger, Rosario Mazarro Berdonces, Bjoern Kaibel
  • Enol ethers
    Patent number: 10889536
    Abstract: Disclosed are enol ethers compounds. The enol ethers exhibit low volatile organic content and are useful in a variety of chemical applications. The enol ethers can be used in applications as diluents, wetting agents, coalescing aids, paint additives and as intermediates in chemical processes. The enol ethers also have particular utility as film-hardening additives in coating formulations.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: January 12, 2021
    Assignee: Eastman Chemical Company
    Inventors: Matthew Allen Boone, Stephanie Kay Clendennen
  • Pharmaceutical compositions comprising omega-3 fatty acids
    Patent number: 10888537
    Abstract: The present disclosure relates to, inter alia, pharmaceutical compositions comprising omega-3 fatty acids.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: January 12, 2021
    Assignee: Amarin Pharmaceuticals Ireland Limited
    Inventors: Mehar Manku, Jonathan Rowe
  • Process for the preparation of alpha, beta unsaturated aldehydes by oxidation of alcohols in the presence of a liquid phase
    Patent number: 10875821
    Abstract: Process for the preparation of alpha, beta unsaturated aldehydes by oxidation of alcohols in the presence of a liquid phase wherein the liquid phase contains 0.1 to less than 25 weight-% water and wherein the liquid phase contains at least 25 weight-% of alcohol(s) of general formula (II) and alpha, beta unsaturated aldehyde(s) of general formula (I) and wherein the oxidant is oxygen and/or hydrogen peroxide.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: December 29, 2020
    Inventors: Nicolas Vautravers, Joaquim Henrique Teles, Andreas Keller, Kirsten Braunsmann, Andreas Jörg Ufer, Stefan Bauer, Marco Bosch, Vera Luense, Joseph John Zakzeski, Michaela Fenyn
  • Organic anion lithium ionic cocrystal compounds and compositions
    Patent number: 10870665
    Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: December 22, 2020
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Michael John Zaworotko, Naga Duggirala, Adam John Smith, Roland Douglas Shytle
  • Combination therapy using riluzole to enhance tumor sensitivity to ionizing radiation
    Patent number: 10864271
    Abstract: Disclosed is a method of treating a tumor in a patient, comprising (a) administering riluzole in an amount effective to sensitize the tumor cells to ionizing radiation, and (b) irradiating the tumor cells with ionizing radiation in a dose effective to reduce tumor cell growth. The method can further comprise administering an effective amount of one or more additional therapeutic agents.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: December 15, 2020
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Atif Jalees Khan, Suzie Chen, James S. Goydos, Bruce G. Haffty
  • Aromatic enol ethers
    Patent number: 10865172
    Abstract: Disclosed are aromatic enol ethers that have utility as film-hardening additives for coating formulations. The aromatic enol ethers have particular utility as film-hardening additives for water-based coating formulations. The aromatic enol ethers provide improvements in hardness and hardness related properties such as block resistance without contributing to the volatile organic content of the composition.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: December 15, 2020
    Assignee: Eastman Chemical Company
    Inventor: Matthew Allen Boone
  • Methods to produce cannabinoid products from decarboxylated cannabinoid extracts
    Patent number: 10864459
    Abstract: Various aspects of this patent application relate to methods to separate a cannabinoid molecule from other molecules of a decarboxylated cannabinoid extract.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: December 15, 2020
    Assignee: Natural Extraction Systems, LLC
    Inventors: Robert C. Wagner, C. Russell Thomas, Douglas G. Metcalf
  • Organic compounds
    Patent number: 10865173
    Abstract: An allylic oxidation process includes forming a mixture containing ?-Guaiene and an iron (III)-X porphyrin complex catalyst in a sustainable solvent, introducing molecular oxygen into the mixture, and effecting allylic oxidation to produce an ?,ß-unsaturated ketone, Rotundone.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: December 15, 2020
    Assignee: GIVAUDAN S.A.
    Inventors: Fridtjof Schröder, Nicole Pfeiffer