Abstract: The present invention is based on the discovery of new and advantageous properties of a class of known polymeric emulsifiers. The emulsifier class was found to be resistant to degradation by crude bacterial antigen preparations, which degradation caused emulsion instability when using prior art emulsifiers. This allows the formulation of safe, stable, and effective vaccines based on these emulsions of oil and water comprising such bacterial antigens. The polymeric emulsifier is a block copolymer having a general formula A-B-A in which component B is the divalent residue of a water-soluble polyalkylene glycol and component A is the residue of an oil-soluble complex monocarboxylic acid. Preferred emulsifier is a PEG-30-di-(polyhydroxystearate).

Abstract: The invention pertains to the use of therapeutically effective amounts of (a) (i) vitamin C and/or selenium and (ii) at least one of docosahexaenoic acid (22:6; DHA), eicosapentaenoic acid (20:5; EPA) and docosapentaenoic acid (22:5; DPA), or esters thereof; or (b) (i) vitamin C and/or selenium and (iii) one or more of uridine and cytidine, or salts, phosphates, acyl derivatives or esters thereof; or (c) a combination of (i), (ii) and (iii); wherein (a), (b) or (c) optionally further comprises vitamin E, in the manufacture of a product for therapeutically improving synaptic connectivity and/or therapeutically supporting memory and/or cognitive function in a human subject in need thereof.

Abstract: Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

Abstract: There is proposed a method for the sterilization of products containing bacteriophages in a manner that will allow the bacteriophages to retain their activity and infectivity. Products containing bacteriophages are exposed to supercritical CO2 under conditions causing little or no damage to structural integrity of the bacteriophages or to the structural properties of biodegradable scaffolds containing the bacteriophages.

Abstract: Synthesis of a compound 4,4?-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde and its use as an insecticidal agent.

Abstract: What are described are aqueous wax dispersions based on ethylene glycol fatty acid esters of specific fatty acids that can be used both as opacifiers and for improvement of conditioning action in formulations for haircare.

Abstract: The present invention relates to a composition for treating keratin fibers, preferably hair, comprising (a) tartaric acid, (b) at least one aromatic alcohol, (c) at least one organopolysiloxane selected from polydialkylsiloxane, polydiarylsiloxane, and polyalkylarylsiloxane, and (d) at least one amino-modified silicone.

Abstract: This invention relates to a monolithic molded part comprising multiple cohesive matrices for the simultaneous diffusion of volatile active ingredients, in contact or separately, wherein said multiple matrix is formed by the combination of several simple matrices, characterized in that each of said simple matrices is capable of containing one or more active ingredient(s), each active ingredient having its own release kinetics.

Abstract: The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) formulated in a pullulan hydrogel The release profile of the FAK inhibitor can be adjusted according to the nature of the wound, e.g., excisional wounds, burn wounds, etc.

Abstract: An antimicrobial solution for a medical device having a chamber defined by a wall, the chamber being configured to be includes water, and an amount of iodine in the water sufficient to generate free elemental iodine when introduced into the chamber of the medical device. The free elemental iodine is configured to diffuse through the wall of the chamber and/or be embedded in the wall of the chamber of the medical device to form an antimicrobial polymer on the wall of the chamber.

Abstract: The present invention provides a ready to use stable aqueous dosage form of norepinephrine comprising an aqueous solution of norepinephrine or its pharmaceutically acceptable salt, one or more sulfite antioxidants and an ion chelator. The present invention also provides an infusion container filled with an aqueous solution of norepinephrine or its pharmaceutically acceptable salt, wherein the said solution is stable for a prolonged period of time and can be terminally sterilized by autoclaving.

Abstract: The present invention is directed to a process for electrochemically whitening a tooth, the process comprising: a) contacting the tooth with a whitening gel that is located in a dental device, the dental device comprising a positive electrode and a negative electrode; b) flowing a current between the positive electrode and the negative electrode through the whitening gel to whiten the tooth; wherein the whitening gel comprises: water; a bleaching agent; a thickener composition comprising a non-ionic compound; a surfactant; and an electrolyte source comprising a first conductive salt.

Abstract: The present invention relates to a rodenticide bait composition comprising a calcium salt and a dehydrant; wherein the calcium salt is selected from the group consisting of calcium carbonate, calcium citrate, calcium acetate, calcium benzoate, calcium octanoate, calcium stearate, calcium silicate, calcium oxide silicate, calcium sulfate, calcium chloride, calcium bromide, calcium iodide, calcium lactate, calcium gluconate, calcium oxalate, calcium phosphate and combinations of two or more thereof; wherein the calcium salt is present in an amount of less than 20 wt. % based on the total weight of the composition; wherein the dehydrant comprises one or more sources of cellulose and one or more sources of phospholipids.

Abstract: The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5 inhibitor and/or a salt thereof, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.

Abstract: Provided herein are dietary supplement compositions comprising a plurality of beadlets and an oil. Provided herein are also dietary supplement compositions comprising a plurality of mini-tabs and oil. The beadlets or mini-tabs comprise at least one nutrient that is miscible in aqueous solution, and the oil comprises at least one fat-soluble nutrient. The composition may be contained within one or more capsules, and be packaged with a scented insert.

Abstract: Provided herein are dietary supplement compositions comprising a plurality of beadlets and an oil. Provided herein are also dietary supplement compositions comprising a plurality of mini-tabs and oil. The beadlets or mini-tabs comprise at least one nutrient that is miscible in aqueous solution, and the oil comprises at least one fat-soluble nutrient. The composition may be contained within one or more capsules, and be packaged with a scented insert.

Abstract: An intra-oral, nanoemulsion blend is provided that enhances liver and toxin excretion performance in mammals when orally administered. A solid powder toxin binding composition also is provided that may be used to irreversibly bind the toxins reaching the bowel so that once the toxins are excreted into the bowel, they may not be reabsorbed, and are thus eliminated. A method of administering the nanoemulsion blend and the toxin binding composition to enhance toxin excretion also is described. The nanoemulsion blend is ingestible and edible.

Abstract: This invention relates to an antimicrobial product containing silver-copper particles and its preparation method. The product includes a substrate and positively charged silver particles with a particle size of 15 ?m to 50 ?m, and a positively charged copper particle with a particle size of 10 ?m to 50 ?m, wherein the copper particle size ratio to the silver particle is 0.8 to 1.2. The silver particle, the copper particle and the substrate are combined by means of semi-fused sintering, wherein the ratio of the silver particle to the copper particle is 40:60 to 95:5. The sum of the substrate, the silver particles and the total particles of the copper particles is less than or equal to 10%.

Abstract: A cylindrical body for an implant is capable of maintaining a high patency rate by achieving a good antithrombogenicity, a low swelling property and a low Young's modulus. A cylindrical body for an implant includes: a cylindrical substrate having an elongation rate in the longitudinal direction, as measured under a tensile load of 20 N, of from 5 to 100%; and a block copolymer composed of a polyalkylene glycol block(s) and a polyhydroxyalkanoic acid block(s); wherein the ratio of the mass of the polyalkylene glycol with respect to the total mass of the block copolymer is 5 to 25%; and a film composed of the block copolymer has a Young's modulus of 200 MPa or less.

Abstract: Methods of protecting fruit crops from flying insect pests and of repelling flying insects using aromatic amide compounds are disclosed. The methods apply the compounds to various surfaces, such as the fruit crops, the ground or structures adjacent to the fruit crops, or an object, article, human skin or animal.