Patents Examined by Snigdha Maewall
  • Methods of treating arthritis
    Patent number: 10736846
    Abstract: The present invention provides methods of treating arthritis. A sustained release composition comprising liposomes and one or more therapeutic agent or a pharmaceutically acceptable salt thereof is administered to a subject in need thereof. The liposomes may be in an aqueous suspension. The sustained release composition can be administered intraarticularly.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: August 11, 2020
    Assignees: TAIWAN LIPOSOME CO., LTD., TCL BIOPHARMACEUTICALS, INC.
    Inventors: Keelung Hong, Luke S. S. Guo, Yun-Long Tseng, Sheue-Fang Shih, Po-Chun Chang, Chih-Chiang Tsai, Hong-Hui Lin
  • Topical antiviral compositions, delivery systems, and methods of using the same
    Patent number: 10736839
    Abstract: The present invention relates generally to topical antiviral compositions, delivery systems, and methods of using the same.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: August 11, 2020
    Assignee: Novan, Inc.
    Inventors: Kimberly McHale, Ryan Doxey, Nathan Stasko
  • Topical ophthalmic formulations of endothelin receptor antagonists
    Patent number: 10716750
    Abstract: The present invention relates to a topical ophthalmic formulation comprising at least one antagonist of the endothelin receptor, preferably selected from sitaxentan, ambrisentan, atrasentran, bosentan, macitentan and tezosentan, or a mixture thereof, more preferably bosentan. It also relates to the use of a topical ophthalmic formulation comprising at least one antagonist of the endothelin receptor, preferably selected from sitaxentan, ambrisentan, atrasentran, bosentan, macitentan and tezosentan, or a mixture thereof, more preferably bosentan, as active ingredient for preventing and/or treating the retinal neurodegeneration induced by diabetes and/or aging.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: July 21, 2020
    Assignee: Retinset, S.L.
    Inventors: Vicente Duran Muiños, Marta Guerrero Martínez, Cristina Hernández Pascual, José Bruno Montoro Ronsano, Rafael Simó Canonge, José Maria Suñé Negre, José Ramón Ticó Grau
  • Topical regional neuro-affective therapy with cannabinoids
    Patent number: 10716766
    Abstract: A method of treating a disease state or condition in humans via topical brainstem afferent stimulation therapy via the administration of a cannabinoid drug(s) to the back of the neck of a human patient to provide regional neuro-affective therapy is disclosed. In certain preferred embodiments, the cannabinoid drug(s) are not psychoactive or substantially not psychoactive. In certain embodiments, the cannabinoid drug(s) are incorporated into a pharmaceutically acceptable topical carrier, e.g., a cream. In certain preferred embodiments, the cannabinoid drug(s) comprises cannabidiol.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: July 21, 2020
    Assignee: AfGin Pharma, LLC
    Inventor: Ronald Aung-Din
  • Solubilization of pterostilbene and resveratrol for aqueous beverages
    Patent number: 10703699
    Abstract: In one embodiment, the present application discloses compositions and methods of solubilizing pterostilbene or resveratrol, or mixture thereof in aqueous media.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: July 7, 2020
    Assignee: Ironstone Separations, Inc.
    Inventors: James D. McChesney, Igor Nikoulin, Douglas L. Rodenburg
  • Reactive oxygen species (ROS)-responsive compositions and methods thereof
    Patent number: 10695288
    Abstract: A reactive oxygen species savaging emulsion; the emulsion comprising an injectable pharmaceutically acceptable composition and a polymeric poly(propylene sulfide) microsphere for targeted delivery to a site with elevated reactive oxygen species. In embodiments of the present invention, the microsphere is loaded with a biologically active agent.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: June 30, 2020
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, John R. Martin, Kristin P. O'Grady, Christopher E. Nelson
  • Amorphous calcium carbonate for the treatment of calcium malabsorption and metabolic bone disorders
    Patent number: 10688124
    Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: June 23, 2020
    Assignee: AMORPHICAL LTD
    Inventors: Amir Sagi, Assaf Shechter, Galit Shaltiel-Gold, Michal Daniely, Oren Meiron
  • Low-toxicity sophorolipid-containing composition and use therefor
    Patent number: 10688031
    Abstract: The present invention provides a low-toxicity sophorolipid-containing composition. The low-toxicity sophorolipid-containing composition contains at least a coloring component, an acidic sophorolipid, a fatty acid, and a hydroxy fatty acid that are derived from an SL-producing yeast culture. The composition contains the following components in the following proportions, in terms of dry weight, based on the total amount of the acidic sophorolipid, a lactonic sophorolipid, the fatty acid, and the hydroxy fatty acid in the composition taken as 100 mass %: (1) acidic sophorolipid: 94 to 99.99 mass %, (2) lactonic sophorolipid: 0 to 2 mass %, (3) total amount of fatty acid and hydroxy fatty acid: 0.01 to 4 mass %.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: June 23, 2020
    Assignee: Saraya Co., Ltd.
    Inventors: Hitoshi Ito, Michiaki Araki, Yoshihiko Hirata
  • Treatment of erectile dysfunction and other indications
    Patent number: 10682357
    Abstract: The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5 inhibitor and/or a salt thereof, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: June 16, 2020
    Assignee: Strategic Science & Technologies, LLC
    Inventor: Eric T. Fossel
  • Colonic drug delivery formulation
    Patent number: 10668023
    Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: June 2, 2020
    Assignee: University College London
    Inventors: Abdul Waseh Basit, Valentine Chidi Ibekwe
  • Pharmaceutical composition containing 8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione or a pharmaceutically acceptable salt thereof
    Patent number: 10668073
    Abstract: The present invention relates to a pharmaceutical composition comprising linagliptin or a pharmaceutically acceptable salt thereof as active ingredient, wherein the pharmaceutical composition does not comprise a binder and wherein the pharmaceutical composition is obtained by direct compression.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: June 2, 2020
    Assignee: HEXAL AG
    Inventor: Andreas Krekeler
  • Cholesterol lowering capsules
    Patent number: 10668086
    Abstract: The invention relates to a capsule consisting of a shell and a filling, which contains plant sterol ester and/or plant stanol ester and emulsifier. The capsule is suitable for lowering serum LDL cholesterol level.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: June 2, 2020
    Assignee: RAISIO NUTRITION LTD
    Inventors: Päivi Kuusisto, Ingmar Wester, Leena Koponen, Jari Ekblom, Jouni Niemela
  • Hyperbranched polyglycerol-coated particles and methods of making and using thereof
    Patent number: 10660828
    Abstract: Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: May 26, 2020
    Assignee: Yale University
    Inventors: Yang Deng, Asiri Ediriwickrema, William M. Saltzman
  • Process for bleaching hair
    Patent number: 10632053
    Abstract: The present invention relates to a hair bleaching process for improved and milder bleaching, especially for bleaching human hair. The ready-to-use bleaching composition comprises carboxylic acids in addition to bleaching persalts and oxidizing agents added at the time of use.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: April 28, 2020
    Assignee: KAO GERMANY GMBH
    Inventors: Bernd Nöcker, Anja Aechtner, Peter Bauer, Steven Breakspear
  • Remineralisation of calcified tissue
    Patent number: 10617866
    Abstract: A cosmetic and/or therapeutic treatment of tissue, such as tooth, is disclosed that effects, for instance, whitening and tissue re-building through mineralisation. Further, a method of performing iontophoresis utilizing an aqueous composition of a remineralising agent to achieve mineralisation is disclosed, as well as a kit for performing the mineralization or remineralisation.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: April 14, 2020
    Assignee: Reminova Ltd.
    Inventors: Nigel Pitts, Christopher Longbottom, Joseph Crayston, Dmitri Grinev, Iain McEwing Young
  • Compositions and methods for delivery of omeprazole plus acetylsalicylic acid
    Patent number: 10603283
    Abstract: The present disclosure is directed to a method for delivering a pharmaceutical composition to a patient in need thereof, comprising: administering to said patient a pharmaceutical composition in unit dose form comprising acetylsalicylic acid, or pharmaceutically acceptable salt thereof, and omeprazole, or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: March 31, 2020
    Assignee: GENUS LIFESCIENCES, INC.
    Inventor: John R. Plachetka
  • Composition comprising gelled capsules stabilized by a buffer
    Patent number: 10596081
    Abstract: A composition includes: an aqueous composition (A) including a buffer having a pKa between 4.0 and 8.0 and having no more than one carboxylic acid function; and at least one capsule including a core and a gelled shell including a polyelectrolyte in the gelled state chelated by divalent cations, the shell fully encapsulating the core on the periphery thereof, the capsule being free of eukaryote cells.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: March 24, 2020
    Assignee: CAPSUM
    Inventors: Thomas Delmas, Mathieu Goutayer
  • Formulations for the treatment of pain
    Patent number: 10576047
    Abstract: Formulations and methods are provided for the treatment of pain, and neuropathic pain in particular. The formulations are eutectic mixtures of a capsaicinoid and a local anesthetic agent and/or an anti-pruritic agent.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: March 3, 2020
    Assignee: Grünenthal GmbH
    Inventor: Manoj Maniar
  • Composition and its use for increasing innate immune health
    Patent number: 10568866
    Abstract: A composition of natural and chemical nutrients such as Vitamin C, Vitamin B-complex, Vitamin E, Aronia melanocarpa extract, Fucoidan, Ginger extract, Zinc, Selenium, Alpha lipoic acid, White mulberry extract, Lychee fruit extract and Sour (Tart) cherry fruit extract are made for mammal consumption in liquid or solid form. This specific composition is used for increasing innate immunity in the mammal before and after the infection has occurred.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: February 25, 2020
    Inventor: Matthias W Rath
  • Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
    Patent number: 10557845
    Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: February 11, 2020
    Assignee: Firmenich Incorporated
    Inventors: Catherine Tachdjian, Andrew P. Patron, Sara L. Adamski-Werner, Farid Bakir, Qing Chen, Vincent Darmohusodo, Stephen Terrence Hobson, Xiaodong Li, Ming Qi, Daniel H. Rogers, Marketa Rinnova, Guy Servant, Xiao-Qing Tang, Mark Zoller, David Wallace, Amy Xing, Klaus Gubernator