Abstract: A system is disclosed for simple, non-invasive, sustained delivery of ophthalmic substances to the interior of the eye, for the prevention and treatment of eye diseases and conditions. Liposomes and inverted micelles are disclosed as suitable vehicles, and timed release of the substances is effected. Delivery methods include coating of a lens or injection into the eye.
Type:
Grant
Filed:
August 14, 2014
Date of Patent:
May 8, 2018
Assignee:
Board of Trustees of Northern Illinois University
Inventors:
Elizabeth Gaillard, James Dillon, Jason Friedrichs, Tao Xu, Timothy J. Hagen, Devi Kalyan Karumanchi
Abstract: Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
Type:
Grant
Filed:
February 20, 2014
Date of Patent:
September 5, 2017
Assignee:
NANOPHARMACEUTICALS LLC
Inventors:
Shaker A. Mousa, Faith B. Davis, Paul J. Davis
Abstract: Active encapsulation compositions which are stable in the glassy state at ambient temperatures are prepared by melt extrusion of a ternary carrier blend comprising of 1) a food polymer, 2) a spice or herb, and 3) a low molecular weight sugar or polyol. Such glassy matrices are useful for the encapsulation of encapsulates, in particular, flavors and medications.
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