Patents Examined by Sonya N. Wright
  • Process for the preparation of 3-methyltetrahydrofuran
    Patent number: 6147233
    Abstract: Disclosed is a process for the preparation of 3-methyltetrahydrofuran (3-MeTHF) from 3-(hydroxymethyl)tetrahydrofuran (3-HOMeTHF) by a plurality of process steps comprising (1) esterifying 3-HOMeTHF to produce a carboxylate ester of 3-HOMeTHF, (2) pyrrolyzing the carboxylate ester to produce 3-methylenetetrahydrofuran (3-methyleneTHF), and (3) hydrogenating the 3-methyleneTHF to produce 3-MeTHF. The 3-MeTHF produced in accordance with the present invention is useful as an industrial solvent and as a monomer in the manufacture of polymers such as elastomers.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: November 14, 2000
    Assignee: Eastman Chemical Company
    Inventor: William Anthony Beavers
  • Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate
    Patent number: 6136982
    Abstract: A method for making 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate, as depicted in the following reaction scheme.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: October 24, 2000
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventor: Karl Grozinger
  • Indole derivatives useful as endothelin receptor antagonists
    Patent number: 6136843
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: October 24, 2000
    Assignee: Pfizer Inc
    Inventors: David James Rawson, Kevin Neil Dack, Roger Peter Dickinson, Kim James
  • Benzimidazole inhibitors of fructose 1,6-bisphosphatase
    Patent number: 6110903
    Abstract: Novel benzimidazole compounds of the following structure and their use as fructose-1,6-bisphosphatase inhibitors is described ##STR1##
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: August 29, 2000
    Assignee: Sankyo Company Ltd.
    Inventors: Srinivas Rao Kasibhatla, K. Raja Reddy, Mark D. Erion, Qun Dang, Gerard R. Scarlato, M. Rami Reddy
  • Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone
    Patent number: 6111112
    Abstract: A method for making 3-amino-2-chloro-4-methylpyridine from malononitrile, as depicted in the following reaction scheme.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: August 29, 2000
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventor: Karl Grozinger
  • 2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists
    Patent number: 6110952
    Abstract: This invention relateds to compounds of formula I, (2-imidazolinylamino)benzoxazoles. The compounds have been found to be alpha-2 adrenocepto agonists and are useful for treatment of disorders modulated by alpha-2 adrenoceptors.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: August 29, 2000
    Assignee: The Procter & Gamble Company
    Inventors: Raymond Todd Henry, Russell James Sheldon, William Lee Seibel
  • Neurotrophic difluoroamide agents
    Patent number: 6096762
    Abstract: The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel .alpha.,.alpha.-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: August 1, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Vivekananda M. Vrudhula, Gene M. Dubowchik, Bireshwar Dasgupta, Dolatrai M. Vyas
  • Indolin-2-one derivatives, method for preparing them and pharmaceutical compositions containing them
    Patent number: 6090818
    Abstract: The invention relates to compounds with formula (I), a process for their preparation and pharmaceutical compositions containing them.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: July 18, 2000
    Assignee: Sanofi-Synthelabo
    Inventors: Loic Foulon, Claudine Serradeil-Le Gal, Gerard Valette