Patents Examined by Sreeni Padmanabhan
  • Pyrimidine substituted purine compounds as kinase (S) inhibitors
    Patent number: 9138437
    Abstract: The present invention relates to a purine compound useful as a kinase inhibitor. The compound has the structure: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: September 22, 2015
    Assignee: Verastem, Inc.
    Inventors: DiZhong Chen, Meredith Williams
  • Treatment of prostate carcinoma
    Patent number: 9132105
    Abstract: Disclosed herein are naphthoquinone analogs, such as plumbagin, pharmaceutical compositions that include naphthoquinone analogs, such as plumbagin, and methods of treating diseases and/or conditions such as cancer with naphthoquinone analogs, such as plumbagin. Also included are combination therapies wherein a naphthoquinone analog, such as plumbagin, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: September 15, 2015
    Assignee: Pellficure Pharmaceuticals, Inc.
    Inventor: Per Borgström
  • Propofol based anesthetic with preservative
    Patent number: 9132090
    Abstract: The invention is a sterile pharmaceutical composition for parenteral administration comprised of an oil-in-water emulsion, in which Propofol is dissolved in a water-immiscible lipophilic agents, and surface stabilizing amphiphilic agent, and tonicity modifying water-soluble hydroxy group and preservative preferably, lipophilic organic compound (butylated hydroxytoluene, butylated hydroxyanisole) or its pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: September 15, 2015
    Inventors: Chetan Majmudar, Pradeep Chakravarty Mahadasyam, Minesh Suthar
  • Compositions for inactivating pathogenic microorganisms, methods of making the compositions, and methods of use thereof
    Patent number: 9131680
    Abstract: Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: September 15, 2015
    Assignee: NanoBio Corporation
    Inventors: Theodore C. Annis, James R. Baker, Tarek Hamouda
  • Compositions and methods relating to resveratrol
    Patent number: 9125858
    Abstract: The present invention relates to compositions and methods comprising resveratrol and uses thereof. Some embodiments include compositions and methods with increased bioavailability of resveratrol. Certain embodiments include compositions comprising resveratrol and a solubilizer. Particular embodiments include transmucosal delivery of resveratrol from the composition.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: September 8, 2015
    Assignee: WILMORE LABS L.L.C.
    Inventors: Otis L. Blanchard, Tina C. Blanchard
  • Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase
    Patent number: 9115127
    Abstract: Compounds of Formula (I) are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula (I) have the following structure: where the definitions of the variables are provided herein.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: August 25, 2015
    Assignee: AMGEN INC.
    Inventors: Christiane M. Boezio, Alan C. Cheng, Deborah Choquette, Richard T. Lewis, Michele H. Potashman, Karina Romero, John C. Stellwagen, Douglas A. Whittington
  • Aryl sultam derivatives as RORc modulators
    Patent number: 9115101
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: August 25, 2015
    Assignee: Genentech, Inc.
    Inventors: Monique Bodil van Niel, Benjamin Fauber, Simon Gaines, Alberto Gobbi, Olivier Rene, David Vesey, Stuart Ward
  • Surface anesthetic agent
    Patent number: 9107876
    Abstract: Provided is an anesthetic agent which can exhibit an anesthetic effect rapidly when adhered on mucosal membranes, the skin or the like by means of application or the like in local anesthesia, particularly surface anesthesia. Prepared are: a fast-acting surface anesthetic agent containing lidocaine and ethyl paraaminobenzoate at a specific ratio; and a super fast-acting surface anesthetic agent containing lidocaine, ethyl paraaminobenzoate and adrenaline at a specific ratio.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: August 18, 2015
    Assignee: YAMAGUCHI UNIVERSITY
    Inventors: Koji Harada, Yasutaka Itashiki, Toyoko Harada, Yoshiya Ueyama
  • Nicotinamides as JAK kinase modulators
    Patent number: 9102625
    Abstract: The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: August 11, 2015
    Assignee: PORTOLA PHARMACEUTICALS, INC.
    Inventors: Shawn M. Bauer, Yonghong Song, Qing Xu, Jack W. Rose, Zhaozhong J. Jia, Brian Kane, Wolin Huang, Anjali Pandey, Mukund Mehrotra
  • Plant disease controlling composition and use thereof
    Patent number: 9101139
    Abstract: A plant disease controlling composition containing a pyridazine compound represented by formula (I): wherein R1 represents a chlorine atom, a bromine atom, a cyano group, or a methyl group, and R2 represents a hydrogen atom or a fluorine atom; and at least one carboxamide compound selected from the group consisting of bixafen, isopyrazam, boscalid, fluopyram, fluxapyroxad, sedaxane, penflufen, flutolanil, mepronil, carboxin, thifluzamide, penthiopyrad, and furametpyr.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: August 11, 2015
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Yuichi Matsuzaki
  • Methods and drug products for treating Alzheimer's disease
    Patent number: 9102666
    Abstract: Provided herein are drug products with low dose pioglitazone for use in the treatment (e.g., delay of onset) of cognitive impairment of the Alzheimer's type. Methods of manufacture thereof are also provided. Further provided are methods of treatment for Alzheimer's disease including administering a drug product with low dose pioglitazone. The methods may include determining whether the subject is at risk of developing Alzheimer's disease based upon the subject's age and TOMM40 523 genotype.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: August 11, 2015
    Assignees: ZINFANDEL PHARMACEUTICALS, INC., TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Allen D. Roses, Rajneesh Taneja
  • Stabilized granules containing glyceryl trinitrate
    Patent number: 9101592
    Abstract: Solid pharmaceutical preparation with the active substance glyceryl trinitrate for oromucosal or oral administration characterized in that it contains between 0.05 and 2 weight % glyceryl trinitrate, at least one carrier material, and at least one substance that reduces the volatility of the GTN, whereby this substance is a non-volatile ester stabilizer.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: August 11, 2015
    Assignee: G. POHL-BOSKAMP GMBH & CO. KG
    Inventors: Thomas Zimmeck, Henning Ueck, Julia Gehricke
  • Process for the preparation of a pharmaceutical composition comprising ezetimibe
    Patent number: 9089486
    Abstract: The present invention belongs to the field of pharmaceutical industry and relates to a process for preparing dosage forms containing ezetimibe, comprising the steps of: a) providing a composition comprising ezetimibe, b) sieving a composition comprising a composition of step (a), c) shear mixing of the composition after step (b), preferably the mixing of the composition is carried out by high shear mixing, d) formulation into a dosage form. The present invention also relates to dosage forms containing ezetimibe and ezetimibe and simvastatin, which have been prepared according to the process according to the invention.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: July 28, 2015
    Assignee: LEK PHARMACEUTICALS D.D.
    Inventors: Janez Kerc, Miha Homar, Polona Jurkovic
  • Methods and compositions for treating metabolic syndrome
    Patent number: 9089579
    Abstract: Provided are methods, compositions, systems, and kits for treating metabolic syndrome or a disorder associated with metabolic syndrome, e.g., obesity, dyslipidemia, and/or a diabetic condition, comprising administering systemically to a subject one or more compounds of the Formula (I) and/or (II): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, polymorph, tautomer, isotopically enriched derivative, or prodrug thereof, wherein, L, R1; R2, Z, X, A and B are defined herein.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: July 28, 2015
    Assignee: Topokine Therapeutics, Inc.
    Inventor: Murat V. Kalayoglu
  • Stable, non-irritating topical formulations of hydroquinone
    Patent number: 9089506
    Abstract: Described herein are methods and compositions for increasing the efficacy and decreasing the irritancy of topical formulations of hydroquinone.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: July 28, 2015
    Assignee: Precision Dermatology, Inc.
    Inventors: Ronald M. Gurge, Mark W. Trumbore, Nupoor Devrajbhai Hirani
  • Hydroxylated tricyclic compounds
    Patent number: 9090535
    Abstract: The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water-soluble oligomer.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: July 28, 2015
    Assignee: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Bo-Liang Deng, Hema Gursahani
  • Allantoin-containing skin cream
    Patent number: 9084780
    Abstract: An allantoin-containing skin cream composition can comprise allantoin and at least one anionic or nonionic emulsifier that is substantially hydrophilic and is soluble in water. The composition is in the form of an oil-in-water emulsion. The pH of the composition is in a range of from about 3.0 to about 6.0; preferably, the pH of the composition is from about 5.0 to about 6.0. The composition can further comprise an acidic anionic polymer. A preferred acidic anionic polymer is a carboxypolymethylene polymer. The composition can further comprise a carbohydrate polymer such as galactoarabinan, polygalactose or polyarabinose. The composition can additionally comprise other ingredients such as herbal extracts, an antioxidant component, an emollient component, a chelator, a solvent component, or a preservative component. The composition is useful as a skin protectant.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: July 21, 2015
    Assignee: SCIODERM, INC.
    Inventor: Elliott Farber
  • Isatin compounds, compositions and methods for treatment of degenerative diseases and disorders
    Patent number: 9079853
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: July 14, 2015
    Assignee: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    Inventors: Craig C. Beeson, Christopher C. Lindsey, Yuri K. Peterson, Baerbel Rohrer
  • Pyrido[3,4-B]indoles and methods of use
    Patent number: 9079904
    Abstract: This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: July 14, 2015
    Assignee: Medivation Technologies, Inc.
    Inventors: Rajendra Parasmal Jain, Sarvajit Chakravarty
  • Methods of using derivatives of (?)-venlafaxine
    Patent number: 9072700
    Abstract: Methods of preparing, and compositions comprising, derivatives of (?)-venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: July 7, 2015
    Assignee: Sunovion Pharmaceuticals Inc.
    Inventors: Thomas P. Jerussi, Chrisantha H. Senanayake, Nandkumar N. Bhongle