Patents Examined by Stephanie K Springer
  • Patent number: 10829470
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: November 10, 2020
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Brian W. Metcalf, Zhe Li, Qing Xu, Stephen L. Gwaltney, II, Jason R. Harris, Calvin W. Yee
  • Patent number: 10820592
    Abstract: A fungicidal composition and a method for treating plants using the composition are provided. The composition comprises at least three active ingredient components (A), (B) and (C), optionally together with one or more customary formulation auxiliaries, wherein component (A) is one or more triazole fungicides, component (B) is one or more strobilurin fungicides, and component (C) is one or more benzimidazole fungicides. Further provided is a method for preventing and/or combating pathogenic damage or pest damage in a plant or plant material, which comprises applying on the plant, plant material, part of plant, or surroundings thereof the composition comprising the active ingredient components (A), (B) and (C).
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: November 3, 2020
    Inventor: James Timothy Bristow
  • Patent number: 10786480
    Abstract: The present invention provides methods and pharmaceutical compositions for treating proliferative disorders.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: September 29, 2020
    Assignee: Peloton Therapeutics, Inc.
    Inventors: John A. Josey, Eli M. Wallace, Guangzhou Han
  • Patent number: 10786489
    Abstract: 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile, or a pharmaceutically acceptable salt, amorphous form, polymorph form, or pharmaceutical composition (including solid formulations or liquid formulations) thereof and the use thereof for treating diseases and disorders which can be treated with a RET kinase inhibitor, such as RET-associated diseases and disorders, e.g., proliferative disorders such as cancers, including hematological cancers and solid tumors, and gastrointestinal disorders such as IBS are disclosed.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: September 29, 2020
    Assignee: Loxo Oncology Inc.
    Inventors: Mark Reynolds, Charles Todd Eary
  • Patent number: 10759797
    Abstract: Provided in the present disclosure are a pharmaceutically acceptable salt of an epidermal growth factor receptor (EGFR) inhibitor, a crystal form thereof, a preparation method therefor and an application thereof. The structural formula of the EGFR inhibitor is as shown in formula I, and the pharmaceutically acceptable salt is a mesylate, p-toluenesulfonate, phosphate, hydrochloride or citrate salt of the EGFR inhibitor. The pharmaceutically acceptable salt of EGFR inhibitor of the present disclosure has a specific crystal form, has a higher solubility and stability than a corresponding free base, is more suitable for preparing drugs for use in treating cancer (especially non-small cell lung cancer), and satisfies the requirements for bioavailability and drug efficacy.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: September 1, 2020
    Assignee: Wuxi Shuangliang Biotechnology Co., Ltd.
    Inventors: Ping Zhou, Jiaquan Wu, Shenshuang Jin, Li Li
  • Patent number: 10729665
    Abstract: This invention relates to a pharmaceutical composition comprising or consisting essentially of the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD). The composition is particularly safe and efficacious for use in the treatment of neurological conditions, characterized by hyper-excitability of the central nervous system, convulsions or seizures such as occur in epilepsy. Preferably the CBDV and the CBD are present with at least one non-cannabinoid component of cannabis such as one or more terpenes or a terpene fraction. More particularly the composition further comprises one or more cannabichromene type compounds. Particularly cannabichromene propyl variant (CBCV) and/or cannabichromene (CBC).
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: August 4, 2020
    Assignees: GW Pharma Limited, Otsuka Pharmaceutical Co., Limited
    Inventors: Benjamin Whalley, Claire Williams, Gary Stephens, Thomas Hill
  • Patent number: 10729672
    Abstract: A combination of temsirolimus and trastuzumab in the treatment of cancer is provided. A combination of temsirolimus and HKI-272 is provided. A combination of a trastuzumab and a HKI-272 is also provided. Regimens and kits for treatment of metastatic breast cancer, containing trastuzumab, temsirolimus and/or HKI-272, optionally in combination with other anti-neoplastic agents, or immune modulators are described.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: August 4, 2020
    Assignee: Wyeth LLC
    Inventors: Laurence Moore, Charles Zacharchuk, Sridhar K. Rabindran
  • Patent number: 10716790
    Abstract: It is intended to provide a medicament and a method for treating cancer comprising a compound having MDM2 inhibiting activity and a compound having FLT3 inhibiting activity in combination. The present invention provides a medicament comprising (3?R,4?S,5?R)—N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6?-chloro-4?-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2?-oxo-1?,2?-dihydrodispiro[cyclohexane-1,2?-pyrrolidine-3?,3?-indole]-5?-carboxamide or a pharmaceutically acceptable salt thereof and N-(5-tert-butyl-isoxazol-3-yl)-N?-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea or a pharmaceutically acceptable salt thereof in combination, and a treatment method using these compounds or salts in combination.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: July 21, 2020
    Inventor: Takahiko Seki
  • Patent number: 10702514
    Abstract: Disclosed is the use of O-(3-piperidino-2-hydroxy-1-propyl)-nicotinic amidoxime (BGP15), its tautomers, enantiomers and pharmaceutically acceptable salts thereof for the treatment of Familial Dysaustonomia.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: July 7, 2020
    Inventors: Frances Brenda Lefcort, Michael Jay Brownstein
  • Patent number: 10695333
    Abstract: The present invention relates to a pharmaceutical combination comprising LSZ102 and alpelisib; pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of conditions in which degradation of estrogen receptors combined with PI3K inhibition is beneficial in, for example, the treatment of cancers.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: June 30, 2020
    Assignee: Novartis AG
    Inventors: Tinya Abrams, Larry Alexander Gaither
  • Patent number: 10688070
    Abstract: A preparation for treatment and/or prevention of seizures comprising a non-mammalian derived mixture of serine glycerophospholipids (PS) conjugates, wherein the mixture comprises (a) Eicosapentaenoic acid (EPA) conjugated to PS and (b) Docosahexaenoic acid (DHA) conjugated to PS, and methods of treatment of seizures with same.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: June 23, 2020
    Assignee: ENZYMOTEC LTD.
    Inventors: Daphna Zaaroor Regev, Yael Herzog, Robert Chudnow, Yael Richter, Gali Olga Soria Artzi
  • Patent number: 10668039
    Abstract: The present invention is directed to compositions and methods for treating Adenoid Cystic Carcinoma (ACC).
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: June 2, 2020
    Inventors: Leonard I. Zon, Joseph Mandelbaum
  • Patent number: 10639273
    Abstract: In accordance with one aspect of the invention, injectable particles are provided which comprise (a) a first group of injectable particles comprising first polymeric particles loaded with a first therapeutic agent and (b) a second group of injectable particles comprising second polymeric particles loaded with a second therapeutic agent. The first and second polymeric particles may be the same or different, and the first and second therapeutic agents may be the same or different. Other aspects of the invention pertain to methods of making such particles, to kits that comprise such particles, and to methods of treatment that employ such injectable particles.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: May 5, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Sonali Puri, Robert E. Richard, John E. O'gara
  • Patent number: 10639320
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating liver fibrosis or liver cirrhosis, and more specifically, to a pharmaceutical composition for preventing or treating liver fibrosis or liver cirrhosis comprising a gold-containing agent. The pharmaceutical composition of the present invention, by comprising the gold-containing agent as an active ingredient, not only promotes M2-type transformation of macrophages but also inhibits the activation of stellate cells due to the increase of TREM-2 expression, and is thus expected to be effectively used as a pharmaceutical composition, a food composition, etc., for preventing, treating, or ameliorating liver fibrosis or liver cirrhosis. Additionally, gold-containing agents, such as auranofin, sodium aurothiomalate, and aurothioglucose, have long been used for the treatment of a different disease (rheumatoid arthritis), and thus they have an advantage in that they are less likely to cause adverse effects.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: May 5, 2020
    Inventors: Keon Wook Kang, Nayoun Kim, Kyung Rok Yoon
  • Patent number: 10632112
    Abstract: Provided herein is a combination therapy comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog. The combination therapy is useful for the treatment of HBV infection. Also provided herein are compositions comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: April 28, 2020
    Inventor: George D. Hartman
  • Patent number: 10624836
    Abstract: The present invention relates to the cosmetic use of an essential oil of Achillea, as an active agent for preventing and/or treating the signs of skin ageing, characterized in that this essential oil of Achillea comprises the following compounds, each present at more than 5% by weight relative to the total weight of the essential oil: artemisia ketone, chrysanthenone (two combined isomers), and ascaridole. It also relates to the associated cosmetic process.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: April 21, 2020
    Assignee: L'OREAL
    Inventors: Joan Eilstein, Corinne Ferraris
  • Patent number: 10596140
    Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: March 24, 2020
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Tarek A. Zeidan, Scott Duncan, Christopher P. Hencken, Thomas Andrew Wynn, Carlos N. Sanrame
  • Patent number: 10596163
    Abstract: Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: March 24, 2020
    Assignee: ChemoCentryx, Inc.
    Inventors: Xi Chen, Junfa Fan, Pingchen Fan, Antoni Krasinski, Lianfa Li, Rebecca M. Lui, Jeffrey P. McMahon, Jay P. Powers, Yibin Zeng, Penglie Zhang
  • Patent number: 10596169
    Abstract: This invention provides a novel cancer treatment method in which plinabulin (t-butyl-dehydrophenylahistin or NPI-2358) and a taxane compound (such as docetaxel) are used in combination. Our study has shown that the optimum combination of injecting plinabulin after taxane compound has unexpected enhanced efficacy in large tumor populations in animal model and in NSCLC cancer patients compared to taxane compound treatment alone. In addition, this optimum combination can achieve unexpected safety effect in lowering unbearable side effects of taxane compound, including decreasing its neutropenia rates at all grades and decreasing G-CSF use in cancer patients.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: March 24, 2020
    Assignee: BeyondSpring Inc.
    Inventor: Lan Huang
  • Patent number: 10582710
    Abstract: Disclosed is an arthropod pest control composition having an excellent controlling effect on arthropod pests, which comprises an amide compound represented by formula (1): and an anthranilamide compound represented by formula (2): wherein a combination of R1 and R2 represents a combination wherein R1 is a methyl group and R2 is a chlorine atom, or a combination wherein R1 is a methyl group and R2 is a cyano group, and one or more Delphacidae control compounds selected from the following group (A): Group (A): a group consisting of clothianidin, imidacloprid, thiamethoxam, dinotefuran, fipronil, pymetrozine, a compound represented by formula (I) and a compound represented by formula (II).
    Type: Grant
    Filed: December 26, 2011
    Date of Patent: March 10, 2020
    Inventors: Emiko Sakamoto, Norihisa Sakamoto