Patents Examined by Stephen B. Maebius
  • Renin-inhibiting peptides having an aminomethyl side chain
    Patent number: 5010057
    Abstract: Renin-inhibiting aminomethyl peptides of the formula ##STR1## in which A is H, an alkyl radical, a sulphonyl radical or an amino-protecting group,B, D, E and F each independently is a direct bond or an amino-organo-carbonyl group,R.sup.1 is an optionally substituted alkyl or aryl radical,R.sup.2 is H, alkyl or acyl,R.sup.3 is H, alkyl, aryl or acyl, andR.sup.4 is alkyl, alkoxy, aryl or amino,and physiologically acceptable salts thereof.
    Type: Grant
    Filed: August 17, 1989
    Date of Patent: April 23, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Henning, Gunter Benz, Johannes-Peter Stasch, Andreas Knorr, Wolfgang Bender
  • Novel peptides suppressing the function of the immune system, pharmaceutical compositions containing them and process for preparing same
    Patent number: 5008246
    Abstract: The invention relates to novel peptides and their acid addition salts, suppressing the function of the immune system, pharmaceutical compositions containing these peptides as well as to a process for preparing these peptides and compositions. The peptides are represented by formulae (1) to (16): ##STR1## The novel peptides are useful for the therapy of diseases where a decrease in the activity of the immune system is desirable.
    Type: Grant
    Filed: June 13, 1989
    Date of Patent: April 16, 1991
    Assignee: Richter Gedeon Vegyeszeti Gyar R. T.
    Inventors: Istvan Schon, Olga Nyeki, Lajos Kisfaludy, deceased, Laszlo Denes, Gyorgy Hajos, Laszlo Szporny
  • Method for relieving chronic pain with a somatostatin analog composition
    Patent number: 5006510
    Abstract: A particularly preferred peptide has the amino acid sequence ##STR1## and is combined with a carrier effective to promote passage of the peptide through a patient's skin for an antinociceptive composition useful for relieving pain in a patient experiencing burning pain or hyperesthesia. Topical application of the composition has been found dramatically to reduce such pain in most individuals treated for periods of from about 5-24 hours, and continued control of the pain can be had by daily doses.
    Type: Grant
    Filed: June 20, 1989
    Date of Patent: April 9, 1991
    Inventor: Wladislaw V. Ellis
  • Peptide inhibitors of motor neuron attachment to s-laminin
    Patent number: 5003044
    Abstract: Novel peptides having inhibitor activity toward the binding of motor neurons to s-laminin are disclosed which are selected from the group consisting ofAEKQLREQVGDQYQTVRALAEand fragments thereof containing the essential sequence LRE.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: March 26, 1991
    Assignee: Washington University
    Inventors: Dale D. Hunter, Joshua R. Sanes, John P. Merlie, Steven P. Adams
  • Hexapeptide and medicinal preparation produced from it to treat erosive and ulcerative lesions of gastrointestinal tract
    Patent number: 5002933
    Abstract: A novel hexapeptide is provided having the following structure:Tyr-D-Ala-Gly-Phe-Leu-Glualso provided is a proposed medicinal preparation for treatment of erosive and ulcerative lesions of the gastrointestinal tract comprised of an active principle, said hexapeptide, and a pharmaceutical carrier.
    Type: Grant
    Filed: February 3, 1989
    Date of Patent: March 26, 1991
    Inventors: Valentin A. Vinogradov, Mikhail I. Titov, Vladimir M. Polonsky, Nikolai V. Korobov, Anatoly S. Sokolov, Maria L. Yakusheva, Zhanna D. Bespalova, Mikhail V. Ovchinnikov, Boris L. Pekelis
  • Method of cleavage at methionine of polypeptides
    Patent number: 4960868
    Abstract: A method for cleaving polypeptides at their methionine residue(s) by mean of reaction with cyanogen bromide wherein a solution of guanidium chloride into hydrochloric acid is employed as reaction medium.
    Type: Grant
    Filed: February 13, 1989
    Date of Patent: October 2, 1990
    Assignee: Istituto di Ricerca Cesare Serono SpA
    Inventors: Umberto Canosi, Gabriele De Fazio, Stefano Villa
  • Novel polypeptide having an anti-tumor activity and a method of preparation thereof
    Patent number: 4948875
    Abstract: Disclosed is a human TNF derivative with a reduced tendency to cause adverse side effects that is obtained by replacing the 31st and 32nd arginine residues from the N-terminal of the amino acid sequence of human TNF, which has a potential for causing serious adverse effects, with asparagine residue and threoine residue, respectively, as well as a method of preparing the same utilizing recombinant DNA technology.
    Type: Grant
    Filed: November 20, 1987
    Date of Patent: August 14, 1990
    Assignee: Suntory Limited
    Inventors: Shoji Tanaka, Masafumi Tsujimoto, Yayoi Wada, Nobuo Tsuruoka, Hiroshi Nakazato