Abstract: The present invention relates to devices for killing undifferentiated epithelial cells during cataract surgery on an eye to prevent posterior capsule clouding after the surgery and to a method for performing cataract surgery on an eye including injecting a cell-killing substance between the anterior capsule and the natural lens prior to removing the natural lens from the eye. The cell-killing substance is preferably an acid or base adjusted, aqueous, buffer-containing a solution having a pH in the range between about 1.0 to below 6.5 or about above 7.5 to 14.0 or a buffer-containing hypotonic solution having a salinity less than 0.06%. The devices of the present invention optionally incorporate a viscoelastic material, a dye or a mixture thereof, in combination with the cell-killing substance.