Abstract: An analytical tool for use in analysis of a sample is provided. The analytical tool includes a first unit and a second unit. The first unit has an analysis portion where analysis is performed. The second unit, configured to be coupled with the first unit, has a liquid reservoir for confining a particular liquid used for the analysis of the sample. When the first unit and the second unit are coupled, a fluid passage for conducting the particular liquid from the liquid reservoir into the first unit is formed by only a part of the first unit, or only a part of the second unit, or a combination of respective parts of the first unit and the second unit.

Abstract: Provided are devices that include a polymeric separation medium configured to immobilize one or more constituents of interest in the polymeric separation medium and have an increased pore size upon application of an applied stimulus. Systems including the devices, as well as methods of using the devices, are also provided. Embodiments of the present disclosure find use in a variety of different applications, including detecting whether an analyte is present in a fluid sample.

Abstract: A biochip for the integration of all steps in a complex process from the insertion of a sample to the generation of a result, performed without operator intervention includes microfluidic and macrofluidic features that are acted on by instrument subsystems in a series of scripted processing steps. Methods for fabricating these complex biochips of high feature density by injection molding are also provided.

Abstract: A gas sensor with excellent detection sensitivity is provided. A sensing electrode, which is provided in a mixed-potential gas sensor for measuring a concentration of a predetermined gas component of a measurement gas to sense the predetermined gas component, is formed of a cermet of a noble metal and an oxygen-ion conductive solid electrolyte. The noble metal includes Pt and Au. A range of at least 1.5 nm from a surface of a noble metal particle included in the sensing electrode is a Au enriched region having a Au concentration of 10% or more.

Abstract: A gas sensor capable of measuring a high concentration range is provided. A sensing electrode provided in a sensor element of a mixed-potential gas sensor for measuring the concentration of a predetermined component in a measurement gas is formed of a cermet including a noble metal and an oxygen-ion conductive solid electrolyte. The noble metal includes Pt and Au. A Au abundance ratio, which is an area ratio of a portion covered with Au to a portion at which Pt is exposed in a surface of noble metal particles forming the sensing electrode, is 0.1 or more and less than 0.3.

Abstract: An electrowetting on dielectric (EWOD) device includes a first substrate assembly and a second substrate assembly spaced apart to define a channel between them; an input port in fluid communication with the channel, the input port defining an input well for receiving a fluid for inputting into the channel; and a control port in fluid communication with the channel, the control port defining a control well for receiving a fluid and having a seal that seals the control port in a sealed state in which fluid is restricted from entering the control well from the channel. When the seal is pierced, the control port is placed in an unsealed state permitting fluid to enter the control well from the channel. The electrowetting force may be manipulated to remove the dispensed droplets via an exit port. Multiple cycles of fluid input/droplet manipulation/fluid extraction may be repeated to perform complex reaction protocols.

Abstract: A gas detection device includes: an element portion; a voltage applying unit configured to apply a voltage across a first electrode and a second electrode on surfaces of a solid electrolyte; a current detecting unit configured to detect an output current flowing between the first electrode and the second electrode; and a measurement control unit. The measurement control unit acquires a parameter which has a correlation with a degree of change of the output current increasing as a concentration of sulfur oxides in an exhaust gas increases based on the output current, and performs determination of whether the concentration of sulfur oxides in the exhaust gas is equal to or higher than a predetermined value or detection of the concentration of sulfur oxides in the exhaust gas based on the acquired parameter.

Abstract: A system for the electrochemical detection of ketone levels includes a test strip including an electrode and a counter electrode, the electrode and counter electrode located in a sample reception area. The system further includes a coating on one of the electrode and counter electrode, the coating including a mediator for ketones. Optionally, the mediator is ferricyanide.

Abstract: A dual gate ion sensitive field effect transistor (ISFET) includes a first bias voltage node coupled to a back gate of the ISFET and a second bias voltage node coupled to a control gate of the ISFET. A bias voltage generator circuit is configured to generate a back gate voltage having a first magnitude and a first polarity for application to the first bias voltage node. The bias voltage generator circuit is further configured to generate a control gate voltage having a second magnitude and a second polarity for application to the second bias voltage node. The second polarity is opposite the first polarity.

Abstract: An electrochemical biosensor includes a substrate, a plurality of layered active metal parts, a plurality of layered electrodes, a reaction confinement layer, an electrochemical reactive layer and a cover piece. The substrate is formed with through holes each of which is defined by an interior wall surface and penetrates top and bottom surfaces. Each of the layered active metal parts is formed at least upon a respective one of the interior wall surfaces. The layered electrodes are formed on the layered active metal parts. The reaction confinement layer confines a reactor space over a region where the through holes are formed. The electrochemical reactive layer is disposed in the reactor space and is electrically coupled to the layered electrodes.

Abstract: A probe gas analysis system is provided. The probe gas analysis system comprises a probe body configured to be exposed to a source of process gas. The probe gas analysis system also comprises a sensor cell assembly having a sensor cell with a sensing side and a reference side. The sensing side is disposed to contact the source of process gas, and to generate a signal indicative of a detected difference in oxygen concentration between the reference side and the sensing side. The probe gas analysis system also comprises a substantially permanent seal coupling the sensor cell assembly to the probe body, wherein the substantially permanent seal separates the reference side from the sensing side.

Abstract: An electrochemical fluid sensor for a downhole production tool positionable in a wellbore penetrating a subterranean is provided. The wellbore has a downhole fluid therein. The electrochemical fluid sensor includes a sensor housing positionable in the downhole tool, a sensing solution positionable in the housing (the sensing solution including a mediator reactive to target chemicals), a gas permeable membrane to fluidly isolate the downhole fluid from the sensing solution (the gas permeable membrane permitting the passage of gas to the sensing solution), and a plurality of electrodes positioned about the housing a distance from the gas permeable membrane to measure reaction by the sensing solution whereby downhole parameters may be determined.

Abstract: A method and device are provided for measuring a level of a clinically relevant analyte (such as glucose) in a fluid (such as blood). The device includes a flow path for conducting said fluid through the device; a detection chamber arranged on said flow path; and detector means arranged to detect analyte levels in the fluid in said chamber, wherein: said detection chamber contains a predetermined amount of an analyte such that that analyte mixes with fluid in the detection chamber to form, at the detector means, a calibration sample of the fluid at a time after the arrival of the fluid in said detection chamber, and said detector means is arranged to detect a first analyte level of an unadulterated sample of the fluid at a first time which is before the formation of said calibration sample and to detect a second analyte level of said calibration sample at a second time which is after the formation of said calibration sample.

Abstract: A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes, and a driving power terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.

Abstract: An analytical tool for use in analysis of a sample is provided. The analytical tool includes a first unit and a second unit. The first unit has an analysis portion where analysis is performed. The second unit, configured to be coupled with the first unit, has a liquid reservoir for confining a particular liquid used for the analysis of the sample. When the first unit and the second unit are coupled, a fluid passage for conducting the particular liquid from the liquid reservoir into the first unit is formed by only a part of the first unit, or only a part of the second unit, or a combination of respective parts of the first unit and the second unit.

Abstract: An electrochemical test sensor for detecting the concentration of an analyte in a fluid sample. The electrochemical test sensor includes a housing that has a first end and a second opposing end. The housing includes an opening at the first end to receive a fluid test sample. An electrode assembly includes a substrate, a working electrode, a counter electrode and a reagent. The substrate has a first surface and an opposing second surface. The working electrode is disposed on the first surface of the substrate, and the counter electrode is disposed on the second surface of the substrate. The electrode assembly is positioned within the housing to define a reaction channel. The electrochemical test sensor may be used with a removable lancet mechanism or integrated within a lancet mechanism to form one integral unit.

Abstract: An electrochemical extended-gate transistor (EET) system is provided, the system includes: a field effect transistor (FET), having a gate, a source, and a drain; a potentiostat, having a working electrode, a counter electrode, and a reference electrode; wherein the working electrode is coupled with a detection region, and the counter electrode is coupled with the gate; wherein the detection region, the gate, and the reference electrode are arranged in an ion fluid; wherein the potentiostat is configured to generate redox in the ion fluid by an electrochemical method to detect the target. A method for detecting targets are used to such system.

Abstract: An analytical tool for use in analysis of a sample is provided. The analytical tool includes a first unit and a second unit. The first unit has an analysis portion where analysis is performed. The second unit, configured to be coupled with the first unit, has a liquid reservoir for confining a particular liquid used for the analysis of the sample. When the first unit and the second unit are coupled, a fluid passage for conducting the particular liquid from the liquid reservoir into the first unit is formed by only a part of the first unit, or only a part of the second unit, or a combination of respective parts of the first unit and the second unit.

Abstract: A DNA/RNA detection technology is provided. The open flow detection technique includes a substrate defining a pair of opposing microchannels, a pair of opposing electrodes in the opposing microchannels, and at least one ion exchanging nanomembrane coupled between the opposing microchannels such that the opposing microchannels are connected to each other only through the nanomembrane, wherein the nanomembrane is functionalized with a probe complementary to the macromolecule. A voltammeter is provided to measure the electrical current or potential across the nanomembrane, and detect a change in the measured electrical current or potential to quantify the presence of the macromolecule.

Abstract: A method of operating a sensor system including at least one sensor for detecting an analyte gas and a control system includes electronically interrogating the sensor to determine the operational status thereof and upon determining that the operational status is non-conforming based upon one or more predetermined thresholds, the control system initiating an automated calibration of the sensor with the analyte gas or a simulant gas.