Patents Examined by Sudhakar Katakam
  • Flounder surimi having antioxidant and antihypertensive effects and method of preparing the same
    Patent number: 11541099
    Abstract: Disclosed is a pharmaceutical composition or food composition for the treatment or prevention of hypertension, containing a peptide isolated from a fraction of a flounder surimi hydrolysate as an active ingredient and is based on the finding that the flounder surimi has an effect of reducing blood pressure, and the hydrolysate of the flounder surimi, the fraction of the hydrolysate of the flounder surimi and peptides isolated from the fraction of the hydrolysate of the flounder surimi have an inhibition activity against an angiotensin I converting enzyme (ACE). Thus, peptides isolated from the fraction of the hydrolysate of the flounder surimi can be used for pharmaceutical compositions or food compositions for treating or preventing hypertension.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: January 3, 2023
    Assignee: JEJU NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: You-Jin Jeon, Jae-Young Oh
  • Combination comprising a glucocorticoid and EDO-S101
    Patent number: 11541038
    Abstract: The present invention is directed to a combination comprising a glucocorticoid and a compound of formula I or a pharmaceutically acceptable salt thereof: to a pharmaceutical composition and to a kit both comprising said combination, to the combination, composition or kit for use in the treatment of cancer, and to a method of treatment of cancer in a patient in need thereof comprising administering to said patient an effective amount of said combination, composition or kit.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: January 3, 2023
    Assignee: Purdue Pharmaceutical Products L.P.
    Inventors: Thomas Jorg Mehrling, Enrique Maria Ocio
  • Method for synthesizing peptide containing N-substituted amino acid
    Patent number: 11542299
    Abstract: Methods of producing a peptide containing an N-substituted amino acid or N-substituted amino acid analog of the present invention include the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino acid analog, or an Fmoc-protected peptide; deprotecting a protecting group which have an Fmoc skeleton of the Fmoc-protected amino acid and such by using a base; and forming an amide bond by adding a new Fmoc-protected amino acid and such; and when the peptide is produced by a solid-phase method, the obtained peptide is cleaved off from the solid phase under conditions of weaker acidity than TFA. Furthermore, at least one side chain of the obtained peptide has a protecting group that is not deprotected under basic conditions and is deprotected under conditions of weaker acidity than TFA.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: January 3, 2023
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kenichi Nomura, Terushige Muraoka, Mikimasa Tanada, Takashi Emura
  • Peptides and other agents for treating pain and increasing pain sensitivity
    Patent number: 11535649
    Abstract: Described herein are peptides that can be used to treat pain or increase pain sensitivity in subject in need of treatment. Additionally, peptides of the present disclosure can be administered with an analgesic agent and/or anesthetic agent. Peptides of the present disclosure are suitable for use when a subject in need of treatment has an injury, a chronic disease, a chronic inflammation, Morton's neuroma, operative/post-operative pain, or a combination thereof.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: December 27, 2022
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Arindam Bhattacharjee, Kerri Pryce
  • C1-INH compositions and methods for the prevention and treatment of disorders associated with C1 esterase inhibitor deficiency
    Patent number: 11534482
    Abstract: Compositions and methods for the treatment and/or prevention of disorders associated with C1 esterase inhibitor deficiency are disclosed.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: December 27, 2022
    Assignee: VIROPHARMA BIOLOGICS LLC
    Inventors: Stephen Ruddy, Mark Cornell Manning, Ryan Erik Holcomb
  • Hyper-branched compounds, synthesis and uses thereof
    Patent number: 11530178
    Abstract: The present invention relates to hyper-branched compounds, a method of synthesizing the hyper-branched compounds and applications of the hyper-branched compounds. The hyper-branched compounds of the present invention include hyper-branched fluorinated compounds, hyper-branched fluorinated graphene and hyper-branched amine functionalized graphene oxide.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: December 20, 2022
    Assignee: MEMSIFT INNOVATIONS PTE. LTD.
    Inventor: James Selvaraj Antony Prince
  • Peptides for dry eye disease
    Patent number: 11524045
    Abstract: Disclosed are ophthalmic compositions, methods for using the compositions and kits comprising the compositions for treating dry eye in a subject in need thereof. The composition comprises at least one peptide that is an inhibitor of trans-endothelial migration, an analogue, variant, derivative, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient for treating dry eye and ocular diseases of inflammation.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: December 13, 2022
    Assignee: ALLYSTA PHARMACEUTICALS, INC.
    Inventors: Henry Hsu, Laszlo Otvos
  • C3B binding polypeptide
    Patent number: 11524050
    Abstract: Polypeptides comprising a C3b binding region are disclosed, as well as nucleic acids and vectors encoding such polypeptides, and cells and compositions comprising such polypeptides. Also disclosed are uses and methods using the polypeptides for treating and preventing diseases and conditions.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: December 13, 2022
    Assignee: Complement Therapeutics Limited
    Inventors: Paul Bishop, Simon Clark, Richard Unwin
  • AML antigens and uses thereof
    Patent number: 11524989
    Abstract: The present invention provides novel compounds comprising an antigen of AML cells, and uses thereof.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: December 13, 2022
    Assignee: KLING BIOTHERAPEUTICS B.V.
    Inventors: Hergen Spits, Marijn Aletta Gillissen, Martijn Kedde, Mette Deborah Hazenberg, Paula Maria Wilhelmina van Helden, Wouter Pos
  • Peptide-containing formulations
    Patent number: 11517608
    Abstract: A formulation comprising glutamic acid, or a salt thereof, and an effective amount of a peptide is provided. The invention also provides a method of preparing the formulation, methods of treating a condition using the formulation, and a kit containing components of the formulation. The invention further provides a sustained release formulation for drug substances comprising glutamic acid, or a salt thereof, and an amount of a peptide.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: December 6, 2022
    Assignee: COHBAR, INC.
    Inventors: Kenneth Cundy, Kent K. Grindstaff, Remi Magnan
  • Method for producing amide compound
    Patent number: 11512108
    Abstract: Provided is a novel method whereby an amide compound can be produced by highly stereoselectively and efficiently performing amidation between a plurality of amino acids and/or peptides. A compound of general formula (3) is synthesized by forming an amide bond between the carboxyl group on the right side of general formula (1) in a compound represented thereby and the amino group on the left side of general formula (2) in a compound represented thereby, in the presence of a Lewis acid catalyst and a silylating agent [in formulae (1), (2) and (3), each symbol has the same meaning as defined in claims].
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: November 29, 2022
    Assignee: CHUBU UNIVERSITY EDUCATIONAL FOUNDATION
    Inventors: Hisashi Yamamoto, Wataru Muramatsu, Tomohiro Hattori
  • Method for preparing salicylamine acetate
    Patent number: 11512044
    Abstract: Disclosed is a method for preparing salicylamine acetate. The method comprises the steps of: (1) carrying out amino protection on salicylaldehyde having a structure represented by formula 1 to obtain a compound having a structure represented by formula 2; and (2) carrying out acid hydrolysis to the compound having a structure represented by formula 2 and then reacting the acid-hydrolyzed compound with acetic acid to obtain salicylamine acetate.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: November 29, 2022
    Assignee: TSI GROUP CO., LTD.
    Inventor: Ling Long
  • Process for preparation of amino alcohols
    Patent number: 11512040
    Abstract: A process for the preparation of amino alcohols includes condensing a compound of Formula (II), a stereoisomer, a tautomer, or a salt thereof with a compound of Formula (IIIa) or Formula (IIIb), a stereoisomer, a tautomer, or a salt thereof to form a condensation product; hydroxylating or acyloxylating the condensation product in the presence of an oxidant to obtain a hydroxylation or acyloxylation product; and subjecting the hydroxylation or acyloxylation product to one or more subsequent reactions comprising a hydrolysis reaction, alcohol deprotection, an amino lysis reaction, or a combination of two or more thereof to obtain an amino alcohol of Formula (I).
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: November 29, 2022
    Assignees: BASF SE, BASF CORPORATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Martin Ernst, Stephan Zuend, Bo Su, Ala Bunescu, John F. Hartwig
  • Modified microcystins and nodularins
    Patent number: 11512114
    Abstract: A compound includes cytotoxic agents such as microcystin and nodularin. More specifically, a modified microcystin and/or nodularin compound contains one or more modified substrates, wherein one or more modified substrates include an anchor group directly accessible or transformable for use in conjugation chemistry (incl. click chemistry), for the attachment of a targeting moiety. This compound is useful for cancer treatment.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: November 29, 2022
    Assignee: Cyano Biotech GmbH
    Inventors: Heike Enke, Wolfram Lorenzen, Stefan Jahns, Dan Enke, Timo Niedermeyer, Julia Moschny
  • Polypeptide conjugates for intracellular delivery of stapled peptides
    Patent number: 11510991
    Abstract: The present disclosure provides novel polypeptide conjugates. The polypeptide conjugates disclosed herein comprise a stapled peptide comprising a peptide and at least one staple which holds the peptide in an ?-helical conformation, and a cyclic cell-penetrating peptide (cCPP) conjugated, directly or indirectly, to the stapled peptide. The present disclosure demonstrates that cCPPs can be used to confer consistent cell-permeability to stapled peptides.
    Type: Grant
    Filed: October 28, 2018
    Date of Patent: November 29, 2022
    Assignee: Ohio State Innovation Foundation
    Inventor: Dehua Pei
  • Anti-VEGF protein compositions and methods for producing the same
    Patent number: 11505593
    Abstract: The present disclosure pertains to compositions comprising anti-VEGF proteins and methods for producing such compositions.
    Type: Grant
    Filed: February 8, 2022
    Date of Patent: November 22, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Shunhai Wang, Ning Li, Hunter Chen, Amardeep Singh Bhupender Bhalla
  • Processes for the preparation of (S)-tert-butyl 4,5- diamino-5-oxopentanoate
    Patent number: 11505522
    Abstract: Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: November 22, 2022
    Assignee: CELGENE CORPORATION
    Inventors: John F. Traverse, Michael J. Zacuto, Weihong Zhang, Kirsten Faye Johnson, Maryll E. Geherty, Christopher Marton
  • Polypeptide comprising cell-penetrating sequence and composition comprising same
    Patent number: 11505577
    Abstract: The present application provides: a polypeptide characterized by having an ability of penetrating into a cell and the structure represented by Formula (I) wherein n is a number of 2 to 20; R1 and R2 may independently represent a C1-C4 alkyl group or may bind to each other to form a ring; R3 represents a C1-C10 primary aminoalkyl group; R4 represents a hydrogen atom or a C1-C10 hydrocarbon group; the “n” number of R1, R2, R3, and R4 may independently be the same with or different from each other; and the N-terminus and the C-terminus may or may not be modified independently; and a cell-invasive composition comprising the polypeptide and a substance of interest.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: November 22, 2022
    Assignee: RIKEN
    Inventors: Keiji Numata, Kosuke Tsuchiya, Yu Miyagi, Takaaki Miyamoto
  • Insulin analogues and uses thereof
    Patent number: 11498951
    Abstract: The present invention is in the therapeutic field of drugs for medical conditions relating to diabetes. More specifically the invention relates to insulin analogues of human insulin. The invention provides pharmaceutical compositions comprising such insulin analogues and the uses if the such analogues for the treatment or prevention of medical conditions relating to diabetes.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: November 15, 2022
    Assignee: Novo Nordisk A/S
    Inventors: Frantisek Hubalek, Mathias Norrman, Helle Birk Olsen, Peter Madsen, Thomas Boerglum Kjeldsen, Jeppe Sturis
  • Self-assembling peptides comprising non-Ionic polar amino acids
    Patent number: 11497833
    Abstract: Compositions, peptide solutions and macroscopic scaffolds of self-assembling peptides consisting essentially of non-ionic, polar amino acids are provided. Particular peptides include those comprising, or consisting essentially of, serine, threonine, tyrosine, cysteine, glutamine, asparagine, methionine, tryptophan, hydroxy-proline, and combinations thereof. Methods of sterilizing the self-assembling peptides, and scaffolds comprising the peptides are also provided.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: November 15, 2022
    Assignee: 3-D Matrix, Ltd.
    Inventors: Eun Seok Gil, Marika Rioult, Keiji Nagano, Karl Patrick Gilbert, Toshiro Kiyofuji, Yuya Hasegawa