Abstract: Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.
Type:
Grant
Filed:
March 13, 2020
Date of Patent:
August 3, 2021
Assignee:
Onyx Therapeutics, Inc.
Inventors:
Dustin McMinn, Henry Johnson, Simeon Bowers, David C. Moebius
Abstract: Disclosed is a process for separating and recovering 3-hydroxypropionic acid from an aqueous solution comprising 3-hydroxypropionic acid and acrylic acid, comprising counter current extracting the aqueous solution with ethyl acetate extractant. Further disclosed is a process for separating and recovering 3-hydroxypropionic acid and acrylic acid from an aqueous solution comprising 3-hydroxypropionic acid and acrylic acid.
Type:
Grant
Filed:
June 25, 2004
Date of Patent:
October 9, 2007
Inventors:
Xiangsheng Meng, Paraskevas Tsobanakis, Jeffrey Malsam, Timothy Abraham