Patents Examined by Sudhaker Patel
  • Substituted 1H-pyridinyl-2-ones as GABAA alpha 2/3 ligands
    Patent number: 6352994
    Abstract: Compounds according to Formula (I) or a salt thereof are selective ligands for GABAA receptors useful for treatment of disorders of the central nervous system:
    Type: Grant
    Filed: January 4, 2001
    Date of Patent: March 5, 2002
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian James Collins, Stephen Robert Fletcher, Timothy Harrison, Paul David Leeson, Christopher Richard Moyes, Alan John Nadin, Michael Rowley, Timothy Jason Sparey, Martin Richard Teall
  • &agr;1-adrenergic receptor antagonists
    Patent number: 6300499
    Abstract: Phenylpiperazine derivatives having high affinity for the &agr;1-adrenoreceptor and pharmaceutical compositions containing them. Also disclosed is a method of using the such derivatives to treat benign prostatic hyperplasia.
    Type: Grant
    Filed: September 28, 1998
    Date of Patent: October 9, 2001
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Dennis Bigg, Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Michel Auguet
  • Process for the synthesis of N-benzyl-3-(4-fluorophenyl)-1-4-oxazin-2-one
    Patent number: 6177564
    Abstract: The present invention is concerned with a novel process for the preparation of N-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one of the formula: This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity, in particular, as substance P (neurokinin-1) receptor antagonists.
    Type: Grant
    Filed: September 9, 1999
    Date of Patent: January 23, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Todd D. Nelson, Mahadevan Bhupathy
  • Fluorescence-derivatisation of carbonyl compounds-novel carbonyl reagents
    Patent number: 6060601
    Abstract: Perylene hydrazide imides of the general formula I a process for the preparation thereof, the use thereof as detection reagents for carbonyl compounds, protonic acids, acylating agents and metal salts, and also perylene hydrazones II and bi- and tri-fluorophoric perylene bisimides III, the preparation thereof and methods of using them.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: May 9, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Heinz Langhals, Wolfgang Jona
  • Spiro-azacyclic derivatives, their preparation and their use as tachykinin antagonists
    Patent number: 6046195
    Abstract: The present invention relates to certain spiro-azacyclic derivatives which are tachykinin antagonists and are useful, for example, in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia.
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: April 4, 2000
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Karen Elizabeth Haworth, Eileen Mary Seward, Christopher John Swain