Abstract: An isochronous bus may includes a data signal, a data valid signal, a frame synch signal and a clock signal. The bandwidth of the data signal is partitioned into a plurality of frames. The frame rate may be selected based upon the sample rate of one of the isochronous devices connected to the isochronous bus or maybe some divisor of the data rate of the isochronous bus. Each frame is partitioned into a plurality of data channels. Each data channel transmits data from an isochronous device. A number of bit time slots are allocated to each data channel. The number of bit time slots allocated to each data channel varies based upon the sample rate of the device corresponding to the data channel. In one embodiment, each data channel is allocated more bit time slots than the nominal samples of its corresponding device. In this manner, any drift of the sample clock may be accommodated. A data valid signal is transmitted synchronous to the data signal and the clock signal.