Abstract: Means and methods for treating tumors in a mammal, in particular, malignant solid tumors, using adenovirus derived material and interleukin-3 (“IL-3 ”). Tthe adenovirus derived material preferably encodes IL-3 activity. Such an adenovirus is preferably administered systemically to the mammal, optionally in an isolated perfusion setting. In preferred embodiments, IL-3 activity is combined with other cytotoxic activity.
January 11, 2000
Date of Patent:
December 17, 2002
Crucell Holland B.V.
Marie Elisabeth Draijer-van der Kaaden, Abraham Bout, Dirk Willem van Bekkum