Patents Examined by Sumesh H Kaushal
  • Patent number: 6495131
    Abstract: Means and methods for treating tumors in a mammal, in particular, malignant solid tumors, using adenovirus derived material and interleukin-3 (“IL-3 ”). Tthe adenovirus derived material preferably encodes IL-3 activity. Such an adenovirus is preferably administered systemically to the mammal, optionally in an isolated perfusion setting. In preferred embodiments, IL-3 activity is combined with other cytotoxic activity.
    Type: Grant
    Filed: January 11, 2000
    Date of Patent: December 17, 2002
    Assignee: Crucell Holland B.V.
    Inventors: Marie Elisabeth Draijer-van der Kaaden, Abraham Bout, Dirk Willem van Bekkum