Patents Examined by Sun Jae Loewe
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Patent number: 8759335Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.Type: GrantFiled: January 31, 2005Date of Patent: June 24, 2014Assignee: Vertex Pharmaceuticals IncorporatedInventors: Sara Hadida Ruah, Peter Grootenhuis, Mark Miller, Matthew Hamilton
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Patent number: 8735322Abstract: Cyclohexanedione compounds, which are suitable for use as herbicides.Type: GrantFiled: September 23, 2009Date of Patent: May 27, 2014Assignee: Syngenta LimitedInventors: Christopher John Mathews, John Martin Clough, Kevin Beautement, Melloney Tyte, Louisa Robinson, Stephane AndréMarie Jeanmart
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Patent number: 8703721Abstract: The present invention relates to an arylalkylamine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, a process for preparing the same, and use of the above-mentioned compound as an activating compound (CaSR agonist) of a Ca sensing receptor, a pharmaceutical composition containing the above-mentioned compound as an effective ingredient, etc.Type: GrantFiled: May 12, 2011Date of Patent: April 22, 2014Assignee: Mitsubishi Tanabe Pharma CorporationInventors: Hiroshi Miyazaki, Junko Tsubakimoto, Kosuke Yasuda, Iwao Takamuro, Osamu Sakurai, Tetsuya Yanagida, Yutaka Hisada
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Patent number: 8686002Abstract: The invention relates to compounds of general formula (I), corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof and the prodrugs of said compounds. The invention also relates to the use of said compounds as binding partners for 5-HT5 receptors for treating diseases that are modulated by a 5-HT5 receptor activity, in particular, for treating neurodegenerative and neuropsychiatric disorders as well as signs, symptoms and dysfunctions.Type: GrantFiled: August 21, 2006Date of Patent: April 1, 2014Assignee: AbbVie Deutschland GmbH & Co. KGInventors: Wilhelm Amberg, Astrid Netz, Andreas Kling, Michael Ochse, Udo Lange, Charles W. Hutchins, Francisco Javier Garcia-Ladona, Alfred Hahn
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Patent number: 8680272Abstract: The present invention provides 3-arylethynyl substituted quinazolinone compounds of formula (A) as potential anticancer agents against sixty human cancer cell lines. R1?H, OH, OCH3; R2?H, OH, CH3, OCH3, NO2; R3?H, OH, OCH3, F, Cl; R2+R3=—OCH2O—; R4?H, OH, CH3, OCH3; R5?H, OH, CH3, OCH3; R6?H, OCH3.Type: GrantFiled: March 31, 2011Date of Patent: March 25, 2014Assignee: Council of Scientific & Industrial ResearchInventors: Ahmed Kamal, Farheen Sultana, Erla Vijaya Bharathi, Yellamelli Valli Venkata Srikanth, Arutla Viswanath, Ponnampalli Swapna
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Patent number: 8679730Abstract: The invention relates azide functionalized poly(3-hexylthiophene)s. Various azide functionalized poly(3-hexylthiophene)s and intermediates are disclosed and described, as well as method for making novel monomers that are synthesized and transformed into P3HT-Nmp for use as organic conducting polymers in organic photovoltaic devices.Type: GrantFiled: July 29, 2011Date of Patent: March 25, 2014Assignee: Brookhaven Science Associates, LLCInventors: Yang Qin, Robert B. Grubbs, Young Suk Park
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Patent number: 8673904Abstract: Provided herein are novel epoxide inhibitors of cysteine proteases, compositions comprising the epoxide inhibitors, and packaged pharmaceuticals. Also provided are methods of inhibiting a papain-family cysteine protease and methods of treating or preventing a disease by administering a composition containing an epoxide inhibitor of the invention. The compositions may be administered in combination with another therapeutic agent.Type: GrantFiled: June 13, 2007Date of Patent: March 18, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Matthew S. Bogyo, Amir M. Sadaghiani, Steven Verhelst
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Patent number: 8669362Abstract: Processes are provided which create an aldehyde methylene, or hydrated or hemiacetal methylene attached to a heteroatom of a 6 membered ring without going through an olefinic group and without the necessity of using an osmium reagent. In particular, a compound of formula (I) can be produced from (II) and avoid the use of an allyl amine: (formulae I and II) where R, P1 P3, R3 and Rx are as described herein.Type: GrantFiled: September 5, 2013Date of Patent: March 11, 2014Assignees: Shiongi & Co., Ltd., VIIV Healthcare CompanyInventors: Brian Johns, Maosheng Duan, Toshikazu Hakogi
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Patent number: 8669234Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.Type: GrantFiled: June 7, 2012Date of Patent: March 11, 2014Assignee: Gilead Sciences, Inc.Inventors: Hongyan Guo, Darryl Kato, Thorsten A. Kirschberg, Evan S. Krygowski, John O. Link, Michael L. Mitchell, Jay P. Parrish, James Taylor
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Patent number: 8669114Abstract: The subject of the invention at hand are novel, a little basic, fluorinated pentafluorophenyl imide anions, which can be used as anions in ionic liquids. Methods for producing ionic liquids are described, which contain these novel pentafluorophenyl imide ions as anions, as well as quaternary organic ammonium ions, guanidinium ions, N-organo-pyridinium ions, imidazolium, imidazolidinium or benzimidazolidinium ions, alkyl-alkylidene phosphoranes or aryl-alkylidene phosphoranes as cations. Alternative methods according to the present invention provide ionic liquids through reaction of ketene N,N-diacetals or alkyl or aryl-alkylidene phosphoranes with acids. The ionic liquids according to the present invention are suitable, for example, as solvents for syntheses, as mobile and/or stationary phase in chromatography, as electrolyte systems for batteries, galvanic elements, fuel cells and rechargeable battery packs.Type: GrantFiled: May 17, 2007Date of Patent: March 11, 2014Assignee: Philipps-Universitaet MarburgInventors: Jorg Sundermeyer, Thomas Linder
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Patent number: 8663564Abstract: Embodiments of the present invention relate to carbon dioxide sequestration systems and methods. In an embodiment, the invention includes a method of sequestering carbon dioxide. The method can include mixing carbon dioxide with an alcohol to form a reaction mixture and contacting the reaction mixture with a metal oxide catalyst under reaction conditions sufficient to produce a carbonate as a reaction product. In an embodiment, the invention includes a carbon dioxide sequestration system. The system can include a carbon dioxide supply source, an alcohol supply source, and a reaction vessel. A metal oxide catalyst can be disposed within the reaction vessel. The system can be configured to mix carbon dioxide from the carbon dioxide supply source with an alcohol from the alcohol supply source to form a reaction mixture and contact the reaction mixture with the metal oxide catalyst. Other embodiments are also described herein.Type: GrantFiled: May 23, 2011Date of Patent: March 4, 2014Assignee: Sartec CorporationInventors: Daniel Thomas Nowlan, Clayton V. McNeff
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Patent number: 8664389Abstract: The present invention relates to an improved and novel process for the preparation of high purity crystalline base of Lapatinib of formula-(1) having chemical name N-{3-chloro-4-[(3-fluorobenzyloxy]phenyl}-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl]-2-furyl]-4-quin-azolinamine and its pharmaceutically acceptable salts. The present invention further relates to intermediates according to formula (8) and formula (9) used in this process.Type: GrantFiled: August 12, 2009Date of Patent: March 4, 2014Assignee: Natco Pharma LimitedInventors: Ramanadham Jyothi Prasad, Bhujanga Rao Adibhatla Kali Satya, Nannapaneni Venkaiah Chowdary
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Patent number: 8664423Abstract: A process for the preparation of acylated secondary alcohol alkoxylates and a process for making secondary alcohol alkoxy sulfates comprising the steps of:— preparing secondary alcohol alkoxylates by the afore-mentioned process; and sulfating the secondary alcohol alkoxylates is described.Type: GrantFiled: October 28, 2009Date of Patent: March 4, 2014Assignee: Shell Oil CompanyInventors: Harry Van Der Heijden, Renata Helena Van Der Made, Jan Hermen Hendrik Meurs, Quoc An On, Arie Van Zon
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Patent number: 8664410Abstract: The invention relates to a fluorescent dye of general formula I or II wherein R1, R2, R3 and R4 are independently hydrogen or a branched or unbranched, saturated or unsaturated, aliphatic or aromatic, functionally substituted, or unsubstituted hydrocarbon radical, wherein at least one of the R1 or R2 radicals and one of the R3 or R4 radicals is not hydrogen and the R1 and R3 radicals and/or R2 and R4 radicals in formula I can be bridged to each other, and X and Y independently represent a substituted or unsubstituted C1 or C2 hydrocarbon radical wherein any one carbon unit can be replaced by an N or S heteroatom. The dye is remarkable for its high fluorescence intensity and large Stokes shift in combination with a long fluorescence lifetime.Type: GrantFiled: June 24, 2011Date of Patent: March 4, 2014Assignee: Universitat PotsdamInventors: Pablo Wessig, Kristian Möllnitz, Robert Wawrzinek
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Patent number: 8664204Abstract: Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.Type: GrantFiled: July 12, 2013Date of Patent: March 4, 2014Assignee: Threshold Pharmaceuticals, Inc.Inventors: Mark Matteucci, Jian-Xin Duan, Hailong Jiao
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Patent number: 8653259Abstract: The invention provides the process illustrated in scheme 1 for synthesizing heterocyclic compounds of formula I. In the process, an isothiocyanate of formula II is initially reacted with a primary amine or formula III to give a thiourea of formula IV. Subsequently, the thiourea of formula IV is converted to the corresponding heterocycle of formula I using a base and a sulfonyl chloride.Type: GrantFiled: February 6, 2008Date of Patent: February 18, 2014Assignee: Sanofi-Aventis Deutschland GmbHInventors: Uwe Heinelt, Hans-Jochen Lang
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Patent number: 8642278Abstract: The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.Type: GrantFiled: November 22, 2006Date of Patent: February 4, 2014Assignee: University of South FloridaInventors: Said M. Sebti, Srikumar Chellappan, Nicholas James Lawrence
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Patent number: 8642025Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.Type: GrantFiled: October 12, 2012Date of Patent: February 4, 2014Assignee: Bristol-Myers Squibb CompanyInventors: Carol Bachand, Makonen Belema, Daniel H. Deon, Andrew C. Good, Jason Goodrich, Clint A. James, Rico Lavoie, Omar D. Lopez, Alain Martel, Nicholas A. Meanwell, Van N. Nguyen, Jeffrey Lee Romine, Edward H. Ruediger, Lawrence B. Snyder, Denis R. St. Laurent, Fukang Yang, David R. Langley, Lawrence G. Hamann
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Patent number: 8641816Abstract: Provided are new functionalized surfactants and methods of their preparation and use. The surfactants are compounds of formula I: wherein R1, R2, and R3 are as defined herein.Type: GrantFiled: October 21, 2010Date of Patent: February 4, 2014Assignee: Dow Global Technologies LLCInventors: Matthias S. Ober, Edward D. Daugs, Wanglin Yu, Cynthia L. Rand
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Patent number: 8629288Abstract: The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives, and to the hydrazones formed as intermediates in the process.Type: GrantFiled: February 12, 2009Date of Patent: January 14, 2014Assignee: Bayer Intellectual Property GmbHInventors: Sergii Pazenok, Norbert Lui, Jens-Dietmar Heinrich, Thomas Wollner