Patents Examined by Susan Coe
  • Patent number: 7186516
    Abstract: The present invention provides methods of detecting specific lysis of a cell by a lytic agent. The methods generally involve contacting a labeled target cell with a lytic agent; and detecting fluorescence in the target cell. The target cells are labeled with two fluorescent labels: a first fluorescent label that labels the plasma membrane; and a second fluorescent label that labels the cytosol. Release of the cytosolic label from the target cell indicates that the target cell has been lysed. The invention further provides methods of detecting the presence in a sample of a cell that specifically lyses a target cell. The invention further provides methods of detecting the presence in a sample of an antibody that specifically lyses a target cell. The methods are useful in a variety of applications.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: March 6, 2007
    Assignee: The J. David Gladstone Institutes
    Inventors: Douglas Nixon, Adrian B. McDermott, Scott Furlan, Martin Bigos, Megan Sheehy, Paul Klenerman
  • Patent number: 7163704
    Abstract: The invention discloses an injection made from Chinese herb Ixeris Sonchifolia Hance for treatment of cardio-cerebral vascular diseases and fundus diseases and method of producing thereof. The injection is in a form of lyophilized powder in which the rate of flavone to adenosine is 5 mg:15 ?g or 5 mg:30 ?g. The flavone and adenosine from Ixeris Sonchifolia Hance is more stable in the lyophilized powder form than in liquid form for injection so that it is easy to control the quality of the product so as to make the medicament safe and effective. It has benefit in store.
    Type: Grant
    Filed: April 21, 2003
    Date of Patent: January 16, 2007
    Inventor: Ruixiang Zhang
  • Patent number: 7098244
    Abstract: Provided is an antibacterial agent exhibiting an excellent antibacterial activity effect and exerting a mild influence on the environment and humans. The antibacterial agent of the present invention comprises, as an effective component, a mixture of coumarin analogues extracted from a citrus fruit pericarp, particularly a mixture of coumarin analogues obtained from citrus cold press oil.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: August 29, 2006
    Assignee: Takasago International Corporation
    Inventors: Tadahiro Hiramoto, Ryo Takeuchi, Minoru Hanada, Ritsuko Norose, legal representative, Fumitaka Norose, deceased
  • Patent number: 7087250
    Abstract: A herbal therapeutic composition is provided which enhances respiration comprising coloidal silver, osha root and fresh lobelia herb. Other herbal substituents which further enhance this novel composition are disclosed including licorice root, fresh yerba santa leaf, eyebright, cats claw, rosemary, fresh ginger, and grape seed.
    Type: Grant
    Filed: August 30, 2003
    Date of Patent: August 8, 2006
    Inventor: Artista Marchioni
  • Patent number: 7074437
    Abstract: The increased level of glucose in blood is the result of the destruction of ? cells of the Islets of Langerhans by autoimmune process in insulin-dependent form of diabetes or a relative lack of insulin in insulin-dependent form of diabetes. Constantly present hyperglycemia in diabetes and a relative lack of insulin aid the development of the neuropathy as a late complication of diabetes. For that purpose, a technical problem was set before the inventor with the request of the reduction of glucose in blood, and stopping of the process of the development of the neuropathy as the consequence of the “long” duration of diabetes. Such a mineral-protein preparation was prepared by which glycemia was successfully regulated, but the process was also stopped by depositing of Ca+ in nerve cells. Those early changes caused by diabetes were successfully stopped, so that the appearance of the neuropathy, as a late complication in diabetes, was postponed.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: July 11, 2006
    Inventors: Robert Basic, Mirko Hadzija, Boris Subotic
  • Patent number: 7060726
    Abstract: Provided is an antibacterial agent exhibiting an excellent antibacterial activity effect and exerting a mild influence on the environment and humans. The antibacterial agent of the present invention comprises, as an effective component, a mixture of coumarin analogues extracted from a citrus fruit pericarp, particularly a mixture of coumarin analogues obtained from citrus cold press oil.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: June 13, 2006
    Assignee: Takasago International Corporation
    Inventors: Tadahiro Hiramoto, Ryo Takeuchi, Minoru Hanada, Ritsuko Norose, legal representative, Fumitaka Norose, deceased
  • Patent number: 7060308
    Abstract: A Caralluma extract and a method of making thereof which can be standardized and reproducible, and which prevents the glycosides from decomposition, which can reduce the undesirable non-glycoside components. In the first Caralluma extract, the resinous material does not exceed 0.5% by weight, and, in the second Caralluma extract, the resinous material does not exceed 1.0% by weight. The first extract is produced by optionally pretreatment of plant materials, optional crushing and/or grinding, extraction, and concentration. The filtration step and the resin removal step may be performed optionally. The second extract is produced by contacting the first Caralluma extract with excipients, drying, powdering, sifting and blending. The Caralluma extracts of the present invention can be used for medical purposes and as food additives.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: June 13, 2006
    Inventors: Ramaswamy Rajendran, Kamala Rajendran
  • Patent number: 7056520
    Abstract: Methods and compositions for the treatment, control or prophylaxis of a viral infection in a mammal, the method including administering to the mammal an effective amount of galactofucan sulfate from Undaria.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: June 6, 2006
    Assignee: Marinova Party Limited
    Inventors: J Helen Fitton, Charles Dragar
  • Patent number: 7048932
    Abstract: This invention provides compositions and methods for stimulating the immune system. Such methods include administering an extract, purified peptide-linked glucan or active component thereof from Coriolus versicolor. The methods are particularly useful for prophylactic and therapeutic treatment of secondary immunodeficiency, wherein the immunodeficiency is the result of an infection, a malignant neoplastic disease, an autoimmune disease, a protein losing state, an immunosuppressive treatment, surgery or anesthesia.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: May 23, 2006
    Assignee: The Chinese University of Hong Kong
    Inventors: Albert H. L. Chow, Kevin K. W. Chu
  • Patent number: 7045282
    Abstract: Kidney disease is diagnosed by measuring urinary catalytic iron in humans. Progressive kidney disease is treated by administering an iron chelator to humans. In particular, the progression of kidney disease essentially can be halted and the severity of kidney disease can be reduced by the administration of iron chelators to humans afflicted with a progressive kidney disease. The methods include measuring catalytic iron content in urine in a human afflicted with a progressive kidney disease and administering an iron chelator to the human. The method can include measuring total urinary protein content, blood urea nitrogen or creatinine in a blood sample before, during or after the administration of an iron chelator.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: May 16, 2006
    Assignee: Shiva Biomedical LLC
    Inventor: Sudhir V. Shah
  • Patent number: 7041321
    Abstract: A method is provided for effecting smoke detoxification in a human by using a composition that is made of effective amounts of supercritical extract and hydroalcoholic extract of turmeric.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: May 9, 2006
    Assignee: New Chapter, Inc.
    Inventors: Thomas Newmark, Paul Schulick
  • Patent number: 7037536
    Abstract: The present invention relates to an ?-amylase activity inhibitor, and to food and beverages comprising the ?-amylase activity inhibitor. The ?-amylase activity inhibitor of the present invention exhibits remarkably excellent ?-amylase inhibitory activity as compared with guava extract. Accordingly, food and beverages containing the ?-amylase activity inhibitor are diet food and beverages suitable for people of high blood-sugar level or hyderlipidemia.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: May 2, 2006
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Takashi Makino, Ritsuo Aiyama, Yoriko Deguchi, Masaaki Watanuki, Masako Nakazawa, Harumi Mizukoshi, Masato Nagaoka, Katsuhisa Harada, Kuniko Osada
  • Patent number: 7037643
    Abstract: Kidney disease is diagnosed by measuring urinary catalytic iron in humans. Progressive kidney disease is treated by administering an iron chelator to humans. In particular, the progression of kidney disease essentially can be halted and the severity of kidney disease can be reduced by the administration of iron chelators to humans afflicted with a progressive kidney disease. The methods include measuring catalytic iron content in urine in a human afflicted with a progressive kidney disease and administering an iron chelator to the human. The method can include measuring total urinary protein content, blood urea nitrogen or creatinine in a blood sample before, during or after the administration of an iron chelator.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: May 2, 2006
    Assignee: Shiva Biomedicals, LLC
    Inventor: Sudhir V. Shah
  • Patent number: 7033619
    Abstract: The present invention comprises an apparatus and methods for making herbal extracts. The apparatus employs a percolation vessel having a filter and discharge valve. A heater is provided to heat the contents of the vessel to up to about 60° C. during the cold percolation process. A control is provided to monitor the contents of the vessel and regulate the heater output to obtain and maintain the proper temperature. A pump draws the output of the vessel and recirculates it to the vessel top so that the vessel effluent passes through the vessel charge. The method entails continuously percolating a solvent through a bed of herbaceous material in the vessel at a temperature between room temperature and about 60° C. to produce an extract comprising active principles contained in the herbaceous material. The thus produced extract is highly concentrated and contains a large proportion of the active principles in the raw material.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: April 25, 2006
    Inventor: Earle C. Sweet
  • Patent number: 7025965
    Abstract: A means and method for treating inflammation and pain in animals is described. The compounds include phycocyanin in a pharmaceutically acceptable carrier. Phycocyanin has been found to be a COX-2 selective agent, and therefore alleviates pain and inflammation without the side effects that occur with NSAIDs that are not COX-2 selective.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: April 11, 2006
    Assignee: Pharma Chemie, Inc.
    Inventor: Mark J. Pieloch
  • Patent number: 7008648
    Abstract: A method of suppressing or curbing appetite and treating or preventing obesity comprising administering to a human or other mammal in need of such treatment an effective amount of plant material derived or derivable from plants of the genera Stapelia and Orbea.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: March 7, 2006
    Assignee: Novartis Nutrition AG
    Inventors: David Gregory Corley, James Miller
  • Patent number: 7001622
    Abstract: The present invention describes a composition for preventing pruritis or inflammation that includes field pussy-toes plant extract, and methods of using and manufacturing the same. The compositions of this invention have been found to be especially useful in preventing and treating lesions from poison ivy, chicken pox, and cold sores.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: February 21, 2006
    Inventor: Robert Berndt
  • Patent number: 6998396
    Abstract: Kidney disease is diagnosed by measuring urinary catalytic iron in humans. Progressive kidney disease is treated by administering an iron chelator to humans. In particular, the progression of kidney disease essentially can be halted and the severity of kidney disease can be reduced by the administration of iron chelators to humans afflicted with a progressive kidney disease. The methods include measuring catalytic iron content in urine in a human afflicted with a progressive kidney disease and administering an iron chelator to the human. The method can include measuring total urinary protein content, blood urea nitrogen or creatinine in a blood sample before, during or after the administration of an iron chelator.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: February 14, 2006
    Assignee: Shiva Biomedical, LLC
    Inventor: Sudhir V. Shah
  • Patent number: 6998121
    Abstract: Method for administering streptolysin O to treat various connective tissue disorders in humans and animals such as Dupuytren's contracture, scleroderma, Peyronie's disease, mastistis in animals, and claudication due to peripheral arterial disease.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: February 14, 2006
    Assignee: Milkhaus Laboratory, Inc.
    Inventor: John McMichael
  • Patent number: 6998141
    Abstract: This invention discloses a medication combination, consisting of Baizhu, Danggui, Hanxincao, Huotanmucao, Ainaxiang, Shuodiao, Malan, Ludou, Canger, Daqinggen, Banbianlian, Xingren, Nuzhenzi, Qianhu, Jiatonghao, Yinchenhao, Yujin, Zhishi, Banxia, and Fuling for treating hepatoma and pancreatic cancer, modifies the conventional extraction procedure and is characterized by the inclusion of Poria, which possesses an anti-tumor ability, as the excipient. This medication combination is based on a novel and continuous theory for cancer therapy and traditional Chinese medicine theories. It has made use of nature and characteristics of those abovementioned medications to lead and change the environments for cancer growth inside the patients' bodies, and then to result in the discomfort and revulsion of cancer cells in such environments.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: February 14, 2006
    Inventor: Chien-Yung Lee