Patents Examined by Susan Pellegrino
  • Chromosome 18 marker
    Patent number: 5955355
    Abstract: The present invention relates to the mammalian fsh05 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh05 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh05 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh05 gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh05 and to using such compounds as therapeutic agents in the treatment of fsh05 disorders and neuropsychiatric disorders.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: September 21, 1999
    Assignees: Millennium Pharmaceuticals, Inc., The Regents University of California
    Inventors: Hong Chen, Nelson B. Freimer
  • Chromosome 18 marker
    Patent number: 5939316
    Abstract: The present invention relates to the mammalian fsh22 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh22 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh22 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh22 gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh22 and to using such compounds as therapeutic agents in the treatment of fsh22 disorders and neuropsychiatric disorders.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: August 17, 1999
    Assignees: Millennium Pharmaceuticals, Inc., The Regents University of California
    Inventors: Hong Chen, Nelson B. Freimer
  • Chromosome 18 marker
    Patent number: 5866412
    Abstract: The present invention relates to the mammalian fsh15w6 gene, a novel gene associated with bipolar affective disorder (BAD) in humans. The invention encompasses fsh15w6 nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, fsh15w6 gene products and antibodies directed against such gene products, cloning vectors containing mammalian fsh15w6 gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of fsh15w6 and to using such compounds as therapeutic agents in the treatment of fsh15w6 disorders and neuropsychiatric disorders.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: February 2, 1999
    Assignees: Millennium Pharmaceuticals, Inc., The Regents University of California
    Inventors: Hong Chen, Nelson B. Freimer
  • Method and kit for confirming in vitro diagnosis of coeliac disease
    Patent number: 5817523
    Abstract: In order to diagnose the coeliac disease antiendomysial antibodies are detected through immunofluorescence techniques in culture media in which bioptic fragments of the human enteral mucosa are kept alive. The cultures of the enteral mucosa take place by dipping the bioptic fragment into nutrient liquids with or without the presence of low concentrations of peptic-tryptic digest of gliadin. The peptide fragment of gliadin containing a definite aminoacid sequence capable of production of antiendomysial antibodies to a greater extent than the PT digest, even in very little concentration, is also identified.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: October 6, 1998
    Inventor: Antonio Picarelli