Patents Examined by Susanna Moore
  • Patent number: 11459353
    Abstract: Methods for producing enantiodefined polycyclic compounds, particularly tetracyclic compounds, are provided. More particularly, synthetic methods for producing biologically active enantiodefined steroidal compositions of both natural (“nat-”) and unnatural (“ent-”) absolute stereochemistry are provided. An exemplary method for manufacturing a tetracyclic compound comprises a step of forming a hydrindane intermediate through coupling of a suitably functionalized enyne with a suitably functionalized alkyne and subsequently performing an intramolecular ring-closing reaction to form the tetracyclic compound. Steroidal compounds obtained by this method and methods of using such steroidal compounds in human and/or animal therapeutics and medicines are also provided.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: October 4, 2022
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventor: Glenn C. Micalizio
  • Patent number: 11447454
    Abstract: The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I:
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: September 20, 2022
    Assignee: TRIO MEDICINES LIMITED
    Inventors: Malcolm James Boyce, Liv Thomsen, Donald Alan Gilbert, David Wood
  • Patent number: 11447625
    Abstract: The present invention relates to the technical field of polymer spectral probes, and particularly to a perchloroethylene derivative and use thereof. The perchloroethylene derivative is prepared by reacting a compound A and a perchloroethylene resin. According to the present invention, the fluorescent polymer can be used as a high-selectivity and high-sensitivity enhanced colorimetric and fluorescent polymer probe for Fe3+ and Cr3+ As compared with the organic small molecule spectral probe, the polymer spectral probe has improved mechanical property, film forming property and excellent recyclability, and thus has a strong practicability.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: September 20, 2022
    Assignee: SOOCHOW UNIVERSITY
    Inventors: Dongmei Xu, Wenbo Guo
  • Patent number: 11434242
    Abstract: This invention relates to: (a) compounds of formula Ia (with R1, R4 to R6, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-?-hydroxylase inhibitors; (b) pharmaceutical compositions (comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: September 6, 2022
    Assignee: BIAL—PORTELA & CA, S.A.
    Inventors: Laszlo Erno Kiss, Alexander Beliaev, Tino Rossi, Pedro Nuno Leal Palma, Patrício Manuel Vieira Araujo Soares Da Silva, Rui Pinto, Francisco Cardona
  • Patent number: 11434240
    Abstract: The present invention provides compounds of formula I, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: September 6, 2022
    Assignee: Nimbus Lakshmi, Inc.
    Inventors: Craig E. Masse, Jeremy Robert Greenwood, Donna L. Romero, Geraldine C. Harriman, Ronald T. Wester, Mee Shelley, Joshua Jahmil Kennedy-Smith, Markus Dahlgren, Sayan Mondal, Shaughnessy Robinson
  • Patent number: 11434245
    Abstract: The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: September 6, 2022
    Assignee: Agency for Science, Technology and Research
    Inventors: Jenefer Alam, Soo Yei Ho, Wei Ling Wang, Athisayamani Jeyaraj Duraiswamy
  • Patent number: 11407764
    Abstract: Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: August 9, 2022
    Assignee: IDEAYA BIOSCIENCES, INC.
    Inventors: Muzaffar Alam, Hilary Plake Beck, Michael Patrick Dillon, Marcos Gonzalez-Lopez, James Clifford Sutton, Jr.
  • Patent number: 11407760
    Abstract: The present invention relates to a dioxinoquinoline compound of formula (I) or a pharmaceutically acceptable salt thereof. The invention also provides a preparation method of the compound of formula (I) and a pharmaceutically acceptable salt thereof, as well as uses thereof as a drug, wherein the drug acting as a tyrosine kinase (i.e. VEGFR-2 and c-MET) inhibitor is used for treating disorders related to tyrosine kinase.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: August 9, 2022
    Assignee: BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED
    Inventors: Qiang Zhang, Shannan Yu, Zhongxiang Wang, Shouye Feng, Yueming Sun, Yansheng Liu, Hongbo Zhang, Leifu Yang, Hailong Yang, Likai Zhou, Nanqiao Zheng, Chenming Hu, Zhanqiang Xu
  • Patent number: 11401297
    Abstract: Processes for the synthesis and purification of glycoconjugate derivatives of cholic acid of formula (I) are provided herein.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: August 2, 2022
    Assignee: DIPHARMA FRANCIS S.R.L.
    Inventors: Alessandro Restelli, Philipp Carboni, Gabriele Razzetti
  • Patent number: 11390623
    Abstract: The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R5, a and A are as defined herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D3-mediated (or D3-associated) disorders including, e.g., substance addiction, substance abuse, schizophrenia (e.g., its cognitive symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD or PD), Parkinson's disease, mania, anxiety, impulse control disorders, sexual disorders and depression.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: July 19, 2022
    Assignee: PFIZER INC.
    Inventors: Thomas Allen Chappie, Jaclyn Louise Henderson, Joseph Michael Young, Travis T. Wager, Bethany Lyn Kormos, Nandini Chaturbhai Patel, Simone Sciabola, Jamison Bryce Tuttle, Patrick Robert Verhoest, Joseph Walter Tucker
  • Patent number: 11390645
    Abstract: A process for the synthesis of ?-hydroxy 3-17-(1H-benzimidazol-1-yl)androsta-5,16-diene is described, a compound also known as Galeterone and used in the treatment of prostate cancer, having the formula (6).
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: July 19, 2022
    Assignee: INDUSTRIALE CHIMICA S.R.L.
    Inventors: Francesco Barbieri, Roberto Lenna
  • Patent number: 11370811
    Abstract: Disclosed are bioavailable solid state (17-?)-3-Oxoandrost-4-en-17-yl dodecanoate compositions and methods of use in administration to mammals in need of thereof. The (17-?)-3-Oxoandrost-4-en-17-yl dodecanoate is preferably provided in a solid state crystalline form having a plurality of peaks corresponding to the peaks shown in FIG. 2, a plurality of crystallites ranging in size from about 40 nm to about 60 nm based as identified via powder x-ray diffraction spectra, and a melting point in the range of about 51° C. to about 63° C. The compositions may be provided in oral or injectable administration form for the treatment of conditions such as in need of testosterone therapy.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: June 28, 2022
    Inventors: Kilyoung Kim, Mahesh V. Patel, Nachiappan Chidambaram, Joel Frank
  • Patent number: 11358940
    Abstract: Provided herein are the K-Ras inhibitors of the formulae: Also provided are compositions comprising thereof for treating cancer.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: June 14, 2022
    Assignees: The Regents of the University of California, Leidos Biomedical Research, Inc.
    Inventors: Frank McCormick, Adam Renslo, David Turner, Anna E. Maciag, Marcin Dyba, Elizabeth D. Vo, Joseph Saavedra, Vandana Kumari
  • Patent number: 11352339
    Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30).
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: June 7, 2022
    Assignee: MISSION THERAPEUTICS LIMITED
    Inventors: Alison Jones, Mark Ian Kemp, Martin Lee Stockley, Michael David Woodrow
  • Patent number: 11352359
    Abstract: The present disclosure provides novel compounds useful as PI3K protein kinase modulators, in particular as PI3K delta (?) and/or gamma (?) protein kinase modulators. The present disclosure also provides methods for preparing PI3K protein kinase modulators, pharmaceutical compositions containing them, and methods of treatment, prevention and/or amelioration of PI3K kinase mediated diseases or disorders with them.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: June 7, 2022
    Assignee: RHIZEN PHARMACEUTICALS AG
    Inventors: Prashant Kashinath Bhavar, Swaroop Kumar Venkata Satya Vakkalanka, Govindarajulu Babu
  • Patent number: 11345669
    Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: May 31, 2022
    Assignee: NodThera Limited
    Inventors: David Harrison, Alan Paul Watt, Nicolas Boutard, Charles-Henry Fabritius, Michal Galezowski, Piotr Kowalczyk, Oleksandr Levenets, Jakub Woyciechowski
  • Patent number: 11339163
    Abstract: The present invention discloses novel BRaf inhibitors, compositions comprising these BRaf inhibitors and uses thereof for the treatment, amelioration and/or prevention of cutaneous reactions.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: May 24, 2022
    Assignee: Lutris Pharma Ltd.
    Inventor: Noa Shelach
  • Patent number: 11332467
    Abstract: Solid state forms of Palbociclib dimesylate, processes for preparation thereof and use thereof for preparation of Palbociclib are disclosed.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: May 17, 2022
    Assignee: PLANTEX LTD.
    Inventors: Maurizio Gallina, Paolo Angioletti, Paolo S. Tiseni, Marina Ratkaj
  • Patent number: 11331320
    Abstract: The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: May 17, 2022
    Assignees: Incyte Holdings Corporation, Incyte Cororation
    Inventors: James D. Rodgers, Stacey Shepard
  • Patent number: 11319287
    Abstract: The present invention relates to novel compounds and method for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1) and ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of cancer and conditions involving mitochondrial dysfunction. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: May 3, 2022
    Assignee: MISSION THERAPEUTICS LIMITED
    Inventors: Mark Kemp, Martin Stockley, Alison Jones