Patents Examined by Susannah Lee
  • 7-Amido-isoindolyl compounds and their pharmaceutical uses
    Patent number: 7034052
    Abstract: The invention encompasses 7-amido-isoindolyl compounds and methods of using these compounds and compositions in mammals for treatment, prevention or management of various diseases and disorders. Examples inlcude, but are not limited to, cancer, inflammatory bowel disease and myelodysplastic syndrome.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: April 25, 2006
    Assignee: Celgene Corporation
    Inventors: Hon-Wah Man, George W. Muller, Weihong Zhang
  • Benzofuran derivatives
    Patent number: 7015246
    Abstract: The invention relates to novel benzofuran derivatives, to processes for preparing them and to their uses in medicaments.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: March 21, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Carsten Schmeck, Ulrich Müller, Gunter Schmidt, Josef Pernerstorfer, Hilmar Bischoff, Axel Kretschmer, Verena Vöhringer, Christiane Faeste, Helmut Haning, Markus Hauswald, Delf Schmidt, Martin Zoche, Heiner Apeler, Willi Jonghaus, Peter Reinemer
  • HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use
    Patent number: 7001912
    Abstract: Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity of HIV integrase enzyme and to treat HIV integrase-mediated diseases and conditions.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: February 21, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Atsuo Kuki, Xinqiang Li, Michael Bruno Plewe, Hai Wang, Junhu Zhang
  • 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
    Patent number: 6992096
    Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: January 31, 2006
    Assignee: PTC Therapeutics, Inc.
    Inventors: Gary Mitchell Karp, Seongwoo Hwang, Guangming Chen, Neil Gregory Almstead, Young-Choon Moon
  • Process for making N-vinyl-2-pyrrolidone
    Patent number: 6982337
    Abstract: A process for making N-vinyl-2-pyrrolidone (NVP) is disclosed. The process comprises dehydrating N-(2-hydroxyethyl)-2-pyrrolidone (HEP) in the presence of a catalyst and added water. Adding an effective amount of water into the dehydration process reduces the amount of N-ethyl-2-pyrrolidone (NEP) formed compared with the amount produced in the absence of the added water. Adding water can also sustain high conversions of HEP, minimize heavies formation, and improve selectivity to NVP. The process provides high-purity NVP and avoids a costly crystallization step.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: January 3, 2006
    Assignee: Lyondell Chemical Technology, L.P.
    Inventor: Andrew P. Kahn