Patents Examined by Suzanne M. Noakes
  • Patent number: 10443049
    Abstract: Disclosed are variants of ACE2, pharmaceutical compositions comprising the variants of ACE2, and treatment methods for reducing Angiotensin II (1-8) plasma levels and/or increasing Angiotensin (1-7) plasma levels in a subject in need thereof. The disclosed variants of ACE2 may include polypeptide fragments of ACE2 having ACE2 activity for converting AngII(1-8) to Ang(1-7). Suitable subjects suitable for the disclosed methods of treatment may include subjects having or at risk for developing diabetic and non-diabetic chronic kidney disease, acute renal failure and its prevention, chronic kidney disease, severe hypertension, scleroderma and its skin, pulmonary, kidney and hypertensive complications, malignant hypertension, renovascular hypertension secondary to renal artery stenosis, idiopathic pulmonary fibrosis, liver fibrosis such as in liver cirrhosis patients, an aortic aneurysm, cardiac fibrosis and remodeling, left ventricular hypertrophy, and an acute stroke.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: October 15, 2019
    Assignee: Northwestern University
    Inventors: Daniel Batlle, Jan Wysocki
  • Patent number: 10441637
    Abstract: Methods for crystallizing a molecule of interest, such as a polypeptide, in complex with nucleic acid, including contacting the molecule of interest with selenium-derivatized nucleic acid and crystallizing the molecule of interest/selenium-derivatized nucleic acid complex are provided. Methods for determining the X-ray crystal structure of molecule of interest/selenium-derivatized nucleic acid complexes are also provided. Typically, the method of X-ray crystal structural determination includes selenium single-wavelength anomalous phasing of the selenium-derivatized nucleic acid. In some embodiments the phases for the X-ray crystal structure of the molecule of interest are not provided from another crystal. Also disclosed are methods of affecting a biological process by administering a functional nucleic acid to a cell or a subject and/or by bringing into contact a nuclease and a functional nucleic acid, where the functional nucleic acid is selenium-derivatized nucleic acid.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: October 15, 2019
    Assignee: SeNA Research, Inc.
    Inventor: Zhen Huang
  • Patent number: 10435718
    Abstract: The invention relates to a process for the preparation of a sugar and/or fermentation product from lignocellulosic material.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: October 8, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Johannes Petrus Smits, Elisabeth Maria Gierveld
  • Patent number: 10435721
    Abstract: Provided herein are Metschnikowia species that produce xylitol from xylose when cultured, as well as methods to make and use these Metschnikowia species.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: October 8, 2019
    Assignee: Creatus Biosciences Inc.
    Inventors: Zongli Luo, Hendrik Jurgens Jansen van Vuuren, Allan George DeBono, Andrew Taplin Ferguson
  • Patent number: 10428318
    Abstract: The invention provides engineered enzymes of transsialidase and/or sialyl transferase activity that have increased regioselectivity and/or increased thermostability.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: October 1, 2019
    Assignee: GLYCOM A/S
    Inventors: Andreas Vogel, Ramona Schmiedel, Elise Champion, Gyula Dekany
  • Patent number: 10428320
    Abstract: The invention concerns the determination and evaluation of the crystal structure of autolysin E (AtlE) of Staphylococcus aureus (S. aureus), or a crystallizable fragment of AtlE, a method for producing a crystal of AtlE and the respective crystallization kit, and its use in a method for screening an inhibitor of the N-acetylglucosaminidase activity of AtlE, for obtaining atomic spatial relationship data, and for identifying a binding compound of AtlE, e.g. by in silico screening.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: October 1, 2019
    Assignee: J. Stefan Institute
    Inventors: Marko Miheli{hacek over (c)}, Miha Renko, Dusan Turk
  • Patent number: 10421952
    Abstract: The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolases (OPPAs) having three or more site mutations, methods of production, kits and methods of use to effectively degrade toxic V-agent type chemical compounds such as VX, VR, CVX, and VM.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: September 24, 2019
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Steven P Harvey, Mark A Guelta
  • Patent number: 10415102
    Abstract: Methods that may be used for the electrochemical detection of multiple parameters, including chemical compounds. Further provided are cells that may be used in the electrochemical detection of multiple parameters, including chemical compounds, as well as a kit for the electrochemical detection of multiple parameters, including chemical compounds.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: September 17, 2019
    Assignee: Fredsense Technologies Corp.
    Inventors: Robert Matthew Mayall, Emily Candice Hicks, Margaret Mary-Flora Renaud-Young, David Christopher Lloyd, Lisa Kara Oberding, Iain Fraser Scotney George
  • Patent number: 10415024
    Abstract: The present invention provides polypeptides related to Ralstonia proteins, nucleic acids encoding the same, compositions comprising the same, kits comprising the same, non-human transgenic animals comprising the same, and methods of using the same.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: September 17, 2019
    Inventors: Eric M. Ostertag, Tseten Yeshi
  • Patent number: 10415066
    Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: September 17, 2019
    Assignees: Danmarks Tekniske Universitet, Københavns Universitet
    Inventors: Birger Lindberg Møller, Bjørn Madsen, Dan Stærk, Finn Thyge Okkels, Johan Andersen-Ranberg, Kenneth Thermann Kongstad, Kim Binderup, Mads Bennedsen, Majse Nafisi, Paiman Khorsand-Jamal, Rubini Maya Kannangara, Uffe Hasbro Mortensen, Ulf Thrane, Rasmus John Normand Frandsen
  • Patent number: 10415062
    Abstract: The present invention relates to a genetically modified microorganism for the production of 2,4-dihydroxybutyrate, by metabolic transformation of xylose via the 1,2,4-butanetriol intermediate. The invention also relates to a method for the production of 2,4-dihydroxybutyrate by culturing said genetically modified microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: September 17, 2019
    Inventors: Philippe Soucaille, Gwénaëlle Bestel-Corre, Laurence Dumon-Seignovert
  • Patent number: 10407673
    Abstract: A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO:1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has a low hydrolyzing activity and a high tranglycosylation activity, as compared to those of the wild-type EndoS2. A method for preparing an engineered glycoprotein using the mutant of EndoS2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. The activated oligosaccharide is a glycan oxazoline.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: September 10, 2019
    Assignees: CHO Pharma Inc., Academia Sinica
    Inventors: Nan-Horng Lin, Lin-Ya Huang, Sachin S Shivatare, Li-Tzu Chen, Chi-Huey Wong, Chung-Yi Wu, Ting Cheng
  • Patent number: 10400028
    Abstract: A2M polypeptide compositions containing a non-natural bait region are disclosed. Methods of producing wild-type and variant A2M polypeptides and polynucleotides containing a non-natural bait region are also disclosed. The bait regions of the variant A2M polypeptides demonstrate enhanced protease inhibitory characteristics compared to wild-type A2M. Variant A2M polypeptides that demonstrate longer half-lives upon administration to an organism compared to wild-type A2M are disclosed. The A2M compositions are useful in treating a number of diseases and conditions including inflammation, chronic wounds, and diseases with a pathology associated with proteases.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: September 3, 2019
    Inventors: Lewis Hanna, John David Laughlin, Shawn Robert Browning
  • Patent number: 10391048
    Abstract: The invention discloses a novel high-temperature resistant superoxide dismutase (SOD) and a coding gene and application thereof. The superoxide dismutase has a very high stability and activity under various severe conditions such as high temperature, high acidity or alkalinity and various proteases such as pepsin and trypsin. The superoxide dismutase of the present invention overcomes the problems of the existing SOD products, such as unstability, low in activity or even a complete lack of activity and prone to degradation and inactivation in the digestive tract. And the superoxide dismutase of the present invention is expected to be developed into cosmetics or health-care foods or medicines which are stable in activity and have a good effect.
    Type: Grant
    Filed: December 26, 2016
    Date of Patent: August 27, 2019
    Assignee: Hangzhou Redox Pharmatech Co., Ltd.
    Inventor: Fanguo Meng
  • Patent number: 10392643
    Abstract: A biosynthetic method of making carboxyl CoA from long-chain carboxylic acid including expressing an ACS in a cellular system, feeding a long-chain carboxylic acid to the cellular system, growing the cellular system in a medium, and producing carboxyl CoA.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: August 27, 2019
    Assignee: Conagen Inc.
    Inventors: Hui Chen, Hongxue Wang, Xiaodan Yu
  • Patent number: 10383806
    Abstract: Topical compositions, packaging systems and methods for improving the appearance of skin or at least one sign of aging in skin are described.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: August 20, 2019
    Inventors: Jatinder Rana, Ganesh Diwakar, Heidi Evenocheck, Louise M. Schneider, Deepa Shenoy, John Rebhun, Samantha Roloff, Jeffrey Scholten, Jason N. Rothouse
  • Patent number: 10385094
    Abstract: A colostrum solid extraction process utilizes rennet coagulation prior to pH adjustment to alter the protein profile resulting in an animal feed supplement which enhances feed efficiency and general health. Rennet coagulation is used to produce extracted whey from colostrum. A pH of the extracted whey is adjusted by cooling the extracted whey to below 70 degrees Fahrenheit, adding an first solution to lower the pH of the extracted whey to 4.2 pH, adding a second solution to lower the pH of the extracted whey to 2.5 pH, agitating the extracted whey after reaching 2.5 pH, resting the extracted whey after agitation, and adding a third solution to raise the pH of the extracted whey to 4.2 pH.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: August 20, 2019
    Inventor: Dustin Kjelden
  • Patent number: 10385095
    Abstract: Described herein are methods to produce keratin protein-based biomaterials, the parameters required to achieve improved extraction, the parameters required to improve isolation, the parameters of lyophilization and the grinding process to achieve consistent particulate sizes of protein materials.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: August 20, 2019
    Assignee: Keratin Biosciences, Inc
    Inventors: Luke Burnett, Sarah Ann Boyd
  • Patent number: 10377993
    Abstract: This invention provides a recombinant microorganism into which an acyl-CoA reductase exhibiting excellent activity in a reduction reaction using acyl-CoA as a substrate has been introduced. Such recombinant microorganism comprises a nucleic acid encoding an acyl-CoA reductase comprising any of characteristic Common sequences 1 to 3 introduced into a host microorganism.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: August 13, 2019
    Inventors: Chikara Ohto, Masayoshi Muramatsu, Masakazu Ito, Jun Ogawa, Shigenobu Kishino
  • Patent number: 10377799
    Abstract: A process of forming a gluten-derived flame retardant material includes forming an amine-functionalized flame retardant molecule that includes an aryl halide group and a phosphorus moiety. The process also includes chemically reacting the amine-functionalized flame retardant molecule with a gluten protein under transamidation conditions to bind the phosphorus moiety to a first portion of the gluten protein. The process further includes initiating a cross-coupling reaction between the aryl halide group and amine group of a second portion of the gluten protein to form a gluten-derived flame retardant material.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: August 13, 2019
    Assignee: International Business Machines Corporation
    Inventors: Scott B. King, Brandon M. Kobilka, Joseph Kuczynski, Jason T. Wertz