Abstract: The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inhibiting NF-?B-dependent target gene expression in a cell.

Abstract: The present invention relates to a microorganism which comprises at least one copy of a polynucleic acid sequence which is foreign to the host and which encodes a protein having an enzymic activity, and comprises a chaperone system which assists the expression of the protein in the form of an active enzyme, and to a method for producing a protein having esterase activity using such a microorganism.

Abstract: The present invention provides a firefly luciferase for inexpensive, highly accurate and highly sensitive nucleic acid analysis that uses dATP instead of an expensive reagent having low reactivity to DNA polymerase in the manner of dATP?S, a method of analyzing nucleic acid that uses that luciferase, and a kit for analyzing nucleic acid thereof. The present invention relates to a composition for analyzing nucleic acid that contains luciferase for which reactivity to dATP is equal to or less than 1/400 reactivity to ATP, a method of analyzing nucleic acid that comprises the use of that composition, and a kit for analyzing nucleic acid comprising that composition.

Abstract: Protein lattices are disclosed which have a regular structure with a repeating unit repeating in three dimensions and have many uses, for example to support an array of macromolecular entities for X-ray crystallography. The repeating unit comprises protein protomers which each comprise at least two monomers fused together. The monomers are each monomers of a respective oligomer assembly into which the monomers are assembled for assembly of the protomers into the lattice. The repeating unit comprises protomers comprising at least a first monomer which is a monomer of a first oligomer assembly which has a set of rotational symmetry axes extending in three dimensions, and a further monomer fused to the first monomer which further monomer is a monomer of a further oligomer assembly which has a rotational symmetry axis of the same order as one of the set of rotational symmetry axes of the first oligomer assembly.

Abstract: A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.

Abstract: The present disclosure relates to methods and compositions for engineering photoautotrophic organisms to convert carbon dioxide and light into fatty acid esters and other molecules, including biofuels. The molecules are then secreted by the organism into a growth medium.