Patents Examined by Suzanne Ziska
  • Drug releasing coatings for medical devices
    Patent number: 9289539
    Abstract: The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, an antioxidant, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In some embodiments, the additive is a liquid. In other embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide or ester groups.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: March 22, 2016
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Compositions for treating biofilms and methods for using same
    Patent number: 9283278
    Abstract: Compositions containing a surface active agent and a sub-lethal amount of an antimicrobial agent and methods for using such compositions are provided herein.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: March 15, 2016
    Assignee: Plurogen Therapeutics, Inc.
    Inventors: George Rodeheaver, Adam Katz
  • Macrocyclic serine protease inhibitors
    Patent number: 9284307
    Abstract: Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula Ia or Ib, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: March 15, 2016
    Assignee: Idenix Pharmaceuticals LLC
    Inventors: Christophe Claude Parsy, Francois-Rene Alexandre, Frederic Leroy, Thierry Convard, Dominique Surleraux
  • Drug releasing coatings for medical devices
    Patent number: 9283358
    Abstract: Medical devices are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: March 15, 2016
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Nanoclusters compositions and methods
    Patent number: 9278069
    Abstract: Compositions, methods of making, and methods of using nanoclusters in which the nanoclusters comprise a plurality of nanoparticles having a core of nanoparticles arranged such that the surfaces of the nanoparticles contact adjacent nanoparticles, the nanoparticles comprise an active ingredient, and the nanocluster has a mass median aerodynamic diameter of from about 0.25 ?m to about 20 ?m.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: March 8, 2016
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Cory J. Berkland, Lianjun Shi, Nashwa El Gendy, Carl Plumley, Mark Bailey
  • Anti-viral compounds
    Patent number: 9278922
    Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: March 8, 2016
    Assignee: ABBVIE INC.
    Inventors: Pamela L. Donner, Lissa T. Nelson, Tammie K. Jinkerson, Ryan G. Keddy, Christopher E. Motter, Mark A. Matulenko, Allan C. Krueger, David A. DeGoey, Sachin V. Patel, John T. Randolph, Warren M. Kati, Charles W. Hutchins, Todd N. Soltwedel
  • Natural antimicrobial compositions
    Patent number: 9273272
    Abstract: The present invention provides novel antimicrobial compositions. In one embodiment, the antimicrobial composition comprises an antimicrobial effective amount of a mixture comprising (a) two or more fatty acids, each of which is natural or naturally derived, and (b) at least one of (i) a natural or naturally derived product, (ii) an alcoholic solvent, or (iii) an organic acid or a salt thereof. The present invention also provides a product comprising a preservative effective amount of the aforementioned mixture.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: March 1, 2016
    Assignee: LINCOLN MANUFACTURING INC.
    Inventor: Patrick Jay Lutz
  • Preform produced by electrospinning, method for producing the same and use of such a preform
    Patent number: 9272076
    Abstract: The invention relates to a method for producing a preform by means of an electrospinning process. The present invention also relates to the use of the present preform as a substrate for growing human or animal tissue thereon. The present invention furthermore relates to a method for growing human or animal tissue on a substrate, wherein the present preform is used as the substrate.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: March 1, 2016
    Assignee: Technische Universiteit Eindhoven
    Inventor: Franciscus Petrus Thomas Baaijens
  • Medical devices with an activated coating
    Patent number: 9273191
    Abstract: Implantable medical devices include a substrate having applied thereto a coating including a polymeric material possessing a core and at least one functional group known to have click reactivity.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: March 1, 2016
    Assignees: Sofradim Production, Covidien LP
    Inventors: Sébastien Ladet, Ahmad Robert Hadba
  • Cleansing composition
    Patent number: 9271909
    Abstract: A cleansing composition containing the following components (A) and (B): (A) an ether carboxylate of Formula (1) R1—O—(CH2CH2O)n—CH2—COOX (1) wherein —R1 represents a linear or branched C4-C10 alkyl or alkenyl group, —n represents a number from 0.5 to 20, and —X represents a hydrogen atom or a cation selected from the group consisting of an alkali metal, an alkaline earth metal, ammonium, an alkylammonium, an alkanolammonium, and a glucammonium; and (B) an ether carboxylate of Formula (2) R2—O—(CH2CH2O)m-CH2—COOY (2) wherein —R2 represents a linear or branched C12-C22 alkyl or alkenyl group, —m represents a number from 0.5 to 20, and —Y represents a hydrogen atom or a cation, selected from the group consisting of an alkali metal, an alkaline earth metal, ammonium, an alkylammonium, an alkanolammonium, and a glucammonium.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: March 1, 2016
    Assignees: KAO CORPORATION, KAO CORPORATION, S.A.
    Inventors: Pilar Castan Barberan, Michael Stapels, Takashi Masui, Hiroki Takeuchi, Masahiro Miyaki
  • Shelf stable, reduced corrosion, ready to use peroxycarboxylic acid antimicrobial compositions
    Patent number: 9271494
    Abstract: The present invention relates to shelf stable and/or less corrosive peroxycarboxylic acid antimicrobial compositions, including ready-to-use compositions. Shelf stable compositions can include defined ratios of hydrogen peroxide to peroxycarboxylic acid and/or hydrogen peroxide to protonated carboxylic acid, but need not include strong acid. Reduced corrosion compositions can include carboxylic acid and corrosion inhibitor at acid pH. Compositions of the invention can have advantageous activity against spores.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: March 1, 2016
    Assignee: Ecolab USA, Inc.
    Inventors: Daniel E. Pedersen, Katherine Joan Molinaro, Michael Besse
  • Pharmaceutical formulations useful in the treatment of insomnia
    Patent number: 9265720
    Abstract: There is provided a formulation suitable for transmucosal administration comprising a short acting hypnotic drug, which formulation provides a measurable plasma concentration of drug within 10 minutes of administration. The formulation is capable of providing sleep on demand, and preferably comprises particles of drug, for example zolpidem or a pharmaceutically-acceptable salt thereof and a mucoadhesion promoting agent, such as sodium carboxymethylcellulose, which particles of drug and mucoadhesive are presented upon the surface of larger carrier particles.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: February 23, 2016
    Assignee: Orexo AB
    Inventors: Anders Pettersson, Christer Nyström, Susanne Bredenberg
  • Compositions comprising decitabine and tetrahydrouridine and uses thereof
    Patent number: 9265785
    Abstract: Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: February 23, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Joseph Desimone, Yogen Saunthararajah
  • Stable pharmaceutical compositions comprising a pyrimidine-sulfamide
    Patent number: 9265762
    Abstract: The invention relates to stable pharmaceutical compositions comprising the compound of the below formula, or pharmaceutically acceptable salts, solvates, hydrates or morphological forms thereof.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: February 23, 2016
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Charles Tokunbo Adesuyi, Bruce Hamilton Lithgow, Olivier Lambert, Lovelace Holman
  • Compositions comprising decitabine and tetrahydrouridine and uses thereof
    Patent number: 9259469
    Abstract: Compositions comprising decitabine and tetrahydrouridine for the treatment of blood disorders and hematological and solid malignancies are described.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: February 16, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Joseph Desimone, Yogen Saunthararajah
  • Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
    Patent number: 9248220
    Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, a contrast agent, and an additive.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: February 2, 2016
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Mono (iron hydroxypyrone) and combination (iron hydroxypyrone and GI inflammation inhibiting agents) compositions for anaemia or infections
    Patent number: 9248148
    Abstract: There is provided a composition or kit of parts comprising: one or more compounds capable of treating and/or preventing an inflammatory disease of the gastrointestinal tract: and an iron hydroxypyrone, for increasing the level of iron in a patient's bloodstream and/or treating and/or preventing anaemia such as iron deficiency anaemia. A composition comprising iron hydroxypyrone is also provided for administration to a subject: having or at risk of having achlorhydria; wherein the gastric pH of the subject is equal to or greater than about 4; or wherein the subject has an inflammatory disease of the gastrointestinal tract.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: February 2, 2016
    Assignee: Iron Therapeutics Holdings AG
    Inventor: Michael Arthur Stockham
  • Polysialic acid-based N-trimethyl chitosan gel nanoparticles for systemic drug delivery
    Patent number: 9241913
    Abstract: Gel nanoparticles for encapsulating and delivering a pharmaceutical compound to a patient. The nanoparticles are formed from N-trimethyl chitosan and polysialic acid, preferably in the presence of sodium tripolyphosphate. A ratio of polysialic acid to N-trimethyl chitosan of about 0.5 to 1 produces nanoparticles having diameter of about 100 nm (plus or minus 25 nm) and a zeta potential above 30 milivolts that can stability contain a pharmaceutical compound, such as methotrexate, for delivery to a patient.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: January 26, 2016
    Assignee: Syracuse University
    Inventor: Rebecca A. Bader
  • Pharmaceutical composition comprising nanocrystals
    Patent number: 9241940
    Abstract: The present invention relates to processes for the manufacture of suspensions comprising one or more water soluble or water insoluble pharmaceutical or nutraceutical active ingredients with a particle size in the range of from 0.01 to 10 micron. More specifically, suspensions prepared by this process can be used to formulate pharmaceutical compositions, especially in liquid fill capsules.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: January 26, 2016
    Assignee: MW Encap Limited
    Inventor: Stephen Brown
  • Oral film-form base and oral film-form preparation
    Patent number: 9238004
    Abstract: The present invention provides a film-form base having one or more sugars or sugar alcohols dispersed as fine particles therein, and also provides a film-form preparation containing the base and a drug. The base is produced by dispersing, in an organic solvent having a solubility parameter of 9.7 or higher, an edible polymer soluble in water and the organic solvent, and particles of one or two or more compounds selected from the group consisting of mono- to hexasaccharide sugars and sugar alcohols thereof which have an average particle size of 0.1 ?m to 60 ?m and are insoluble in an organic solvent. The present invention can therefore provide oral film-form base and preparation which have a rapid dissolution profile in the mouth and sufficient film strength, and provide a reduced sticky sensation attributed to the water-soluble polymer in the mouth and an improved feel when handled with the fingers.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: January 19, 2016
    Assignee: NITTO DENKO CORPORATION
    Inventors: Daisuke Asari, Mitsuhiko Hori, Keiko Ogawa