Abstract: The present invention provides a production method of a 5-phthalancarbonitrile compound, which comprises the use of a novel compound of the formula [I]
wherein X is chlorine atom, bromine atom or iodine atom, as a key intermediate; intermediate; and the process of preparing intermediates.
Abstract: This invention relates to compositions comprising a polycarbonate, polyester or polyketone which is subject to oxidative, thermal and/or light-induced degradation, or their mixtures and blends, and at least one benzofuran-2-one type compound, to the use thereof for stabilising polycarbonate, polyester or polyketone or their mixtures or blends against oxidative, thermal and/or light-induced degradation, as well as to a process for stabilising these plastic materials.
Abstract: The present invention is to provided a trifluoro-substituted benzoic acid, an ester thereof, particularly 2,3,4-trifluoro-5-iodobenzonic acid, 2,3,4-trifluoro-5-trifluoromethylbenzonic acid, esters thereof, which are useful as a starting material for synthesizeing a quinolonecarboxylic acid compound useful as a medicine, an anti-bacterial agent or an antiviral agent, and processes for preparing these compounds and 2,4,5-trifluoro-3-iodobenzonic acid, 2,4,5-trifluoro-3-trifluoromethylbenzoic acid and esters thereof.
Abstract: Heterocyclic compounds of the formula:
wherein
R1 is carboxy or protected carboxy,
R2 is aryl which may have suitable substituent(s),
R3 is aryl which may have suitable substituent(s),
R4 is hydrogen, lower alkyl, hydroxy or aryl,
A1 is lower alkylene,
etc.,
etc. and
n is 0 or 1,
and pharmaceutically acceptable salts thereof which are useful as a medicament.
Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
Type:
Grant
Filed:
September 13, 2000
Date of Patent:
October 9, 2001
Assignee:
Sloan-Kettering Institute for Cancer Research
Inventors:
Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dang Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J Sorensen, Aaron Balog, Kenneth A. Savin
Abstract: A process for the preparation of 2,3-dihydroindoles of the formula (I)
by reaction of halostyrenes of the formula (IIa) or (IIb)
with amines of the formula (III)
R1—NH2 (III)
in at least one inert solvent or in water, and in the presence of at least one base.
Type:
Grant
Filed:
November 18, 1999
Date of Patent:
October 2, 2001
Assignee:
Aventis Research & Technologies GmbH & Co. KG
Inventors:
Matthias Beller, Thomas Riermeier, Harald Trauthwein, Claudia Breindl
Abstract: The present invention relates to a process for preparing hydroxamic acids from hydroxylic acid intermediates wherein the carboxylic acid intermediate does not possess reactive substituents such as hydroxy or amino groups.
Abstract: The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I)
in which
Het represents one of the groups
and G, V, W, X, Y and Z are each as defined in the description,
to processes and intermediates for their preparation and to their use as pesticides and herbicides.
Type:
Grant
Filed:
June 4, 1999
Date of Patent:
September 11, 2001
Assignee:
Bayer Aktiengesellschaft
Inventors:
Hermann Hagemann, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Peter Dahmen, Markus Dollinger, Alan Graff, Wolfram Andersch
Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
Type:
Grant
Filed:
October 18, 2000
Date of Patent:
September 4, 2001
Assignee:
Sloan-Kettering Institute for Cancer Research
Inventors:
Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dand Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J Sorensen, Aaron Balog, Kenneth A. Savin
Abstract: The invention relates to compounds of general formula (I), their optically active isomers and salts wherein Ar=alycylic, aromatic or one or more heteroatom containing heterocyclic moiety, optionally substituted by one or more alkoxy-, methylenedioxy-, alkyl-, halogen-, haloalkyl-,or nitro- group and/or condensed with a benzene ring.
Ar—(CR1R2)m—(YR3R4)n—X—(CR5R6)o—(CR7R8)p—C≡C—E (I)
The compounds of general formula (I) according to the invention can be applied as active ingredients of pesticides, preferably arthropodicide compositions, and as synergists of other arthropodicideactive ingredients.
Type:
Grant
Filed:
August 31, 1998
Date of Patent:
August 21, 2001
Assignee:
Chinoin Gyogyszer es Vegyeszeti
Inventors:
Geza Arvai, Ildiko Bakonyvari, Bela Bertok, Laszlo Csiz, Iren Czudor, Zsuzsa R. Kuruczne, Laszlo Pap, Istvan Szekely
Abstract: Compounds having the formula ##STR1## wherein each A may be the same or different and is an alkyl group, a phenyl group or a substituted derivative of a phenyl group;Y may be the same or different and is hydrogen, an unbranched alkyl group, a halide or a group having the structure ##STR2## wherein R is hydrogen, an alkoxide group, an alkyl group, or OH; B may be the same or different and each is hydrogen or an alkyl group;Z.sup.- is a soluble, pharmaceutically acceptable negative ion, andX may be the same or different and is an axial ligand selected from the group consisting of moieties having the formula: ##STR3## The compounds and compositions thereof exhibit antiviral activity.