Abstract: A method for assaying bone resorption rates by quantitating the concentration of peptide fragments derived from bone collagen, found in a body fluid. The method includes immunometric assay, fluorometric assay and electrochemical titration. The structure of specific peptide fragments having 3-hydroxypyridinium cross-links found in urine of Paget's disease patients and procedures for making monoclonal antibodies is also described.
Abstract: Di(D-tryptophyl and/or tetrahydropyridoindolylcarbonyl)-containing peptide amides useful as Substance P agonists and/or antagonists and as antihypertensives and/or analgesics and a process for preparing them are disclosed.
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