Abstract: Disclosed are techniques and a device operable to determine a total amount of insulin delivered to the user over a predetermined time period. The total amount of insulin includes a total basal dosage delivered in basal dosages and a total bolus dosage delivered in bolus dosages over the predetermined time period. A proportion of the total amount of insulin delivered to the user provided via the total basal dosage amount over the predetermined time period is calculated. In response determining the proportion of the total amount of insulin attributed to the total basal dosage amount of insulin exceeds a threshold, an average basal dosage to be delivered within a subsequent time period that is approximately equal to the threshold may be determined. An instruction may be generated and output to deliver a modified basal dosage that substantially maintains the average basal dosage over the subsequent time period.

Abstract: The present disclosure is directed to a device that can be in the form of a sleeve that has a first upper portion and a second lower portion. The first upper portion can include exit ports to allow various catheters, such as peripherally inserted central catheter (PICC) lines, to extend through openings therein. The second lower portion is inverted upwardly over the first portion and can have a securement flap on an outer surface to tighten around the patient's arm and around the PICC line to ensure that the PICC line and the sleeve remain stationary relative to the patient's arm.

Abstract: Medical devices and related systems and methods are provided. A method of estimating a physiological condition using a first sensing arrangement involves obtaining a sensor translation model associated with a relationship between the first sensing arrangement and a second sensing arrangement, wherein the second sensing arrangement is different from the first sensing arrangement, obtaining one or more measurements from a sensing element coupled to the processing system of the first sensing arrangement, determining simulated measurement data for the second sensing arrangement by applying the sensor translation model to the one or more measurements from the sensing element of the first sensing arrangement, and determining an estimated value for the physiological condition by applying an estimation model associated with the second sensing arrangement to the simulated measurement data.

Abstract: An actuation mechanism is presented for a medicament delivery device having a plunger rod arranged to act on a stopper of a medicament container, an actuator arranged slidable and connected to the plunger rod for acting on the stopper when said actuator is operated by displacing it in a longitudinal direction of the actuation mechanism, and an activator for activating the actuation mechanism and for setting a dose. The activator having a generally tubular activator sleeve provided with a spirally extending groove on an outer surface, the groove arranged with a length corresponding to the total amount of medicament to be delivered in a number of doses contained in said medicament container, where the groove is provided with an end wall, a stop ring arranged coaxial with said activator sleeve. The activator sleeve arranged with a follower positioned in the groove and the follower arranged to abut the end wall when the total amount has been delivered.

Abstract: A catheter manufacturing method includes the step of providing a hollow cylindrical part of a catheter, having a longitudinal axis, to be bonded to a given part along respective edge surfaces of the hollow cylindrical and the given parts. One or more undercut structures that are disposed circumferentially with respect to the longitudinal axis and also generally parallel to the longitudinal axis, the undercut structures having a radial orientation with respect to the longitudinal axis, are formed at least in the edge surface of the hollow cylindrical part. The hollow cylindrical part and the given part are connected using the undercut structures.

Abstract: The invention relates to a dose control system configured for an injectable drug delivery device. The device comprises a disk-shaped diametral single-dipole magnet (9) attachable to a rotatable dose wheel, a housing removably attachable to the proximal extremity of the drug delivery body and comprising at least a first and a second magnetic field measurement means (8). An integrated control unit (2) is connected to the magnetic field measurement means and is configured to process information received therefrom. The magnetic field measurement means are located in the housing in a displaced axial relationship relative to the longitudinal axis of the drug delivery body and the magnet.

Abstract: The present disclosure relates to an injection device including: a housing; a carrier disposed within the housing for holding a syringe that has a needle at one end; a needle sleeve located within the housing and being axially moveable with respect to the housing between an extended position and a retracted position; a biasing element configured to bias the needle sleeve towards the extended position; and a locking mechanism configured to lock the needle sleeve in the extended position after use of the injection device, the locking mechanism comprising; a first locking member provided on and projecting from the carrier; and a second locking member comprising a deflectable arm provided on the needle sleeve and moveable between a relaxed position and a deflected position.

Abstract: A drug delivery device includes a housing defining a shell having a proximal and a distal end, a needle assembly at least partially disposed within the housing at the proximal end, a drive assembly at least partially disposed within the housing, and a damper mechanism at least partially disposed within the housing adjacent to the distal end. The housing further defines a longitudinal axis extending between the proximal end and the distal end. The needle assembly includes a syringe barrel containing a medicament and a needle or a cannula. The drive assembly is operably coupled to the needle assembly to urge the medicament through the needle or cannula. The damper mechanism is operably coupled to the drive assembly and the housing. Upon activating the drive assembly, the damper mechanism dampens an effect thereof.

Abstract: A surgical system for controlling fluid pressure during a surgical procedure is provided. Example systems include an inflow pump coupled to a fluid source and defining an outlet port. An inflow cannula is coupled to the outlet port of the inflow pump and includes a barcode disposed thereon. An endoscope extends from a proximal end to a distal end and includes a shaft. A camera is coupled at the proximal end of the endoscope and provides visualization of a surgical site through the shaft and output a corresponding imagery signal. A pump control unit is coupled to the inflow pump and controls an outlet pressure of the inflow pump. A camera control unit is coupled to the camera and to the pump control unit and receives the imagery signal and decodes the barcode and conveys information indicative of a pressure loss across the inflow cannula to the pump control unit.

Abstract: This device is an inserting member fixing device to fix a linear inserting member to an insertion target, the inserting member fixing device comprising: a main body; a chuck portion; an inner sealing portion to be brought into close contact with an outer periphery of the inserting member; an inserting member supporting portion to support the inserting member; and a movement restricting portion to restrict movement of the inner sealing portion and the inserting member supporting portion. The inserting member supporting portion and the inner sealing portion are provided adjacent to each other in an axial direction of the inserting member, and a space is provided between the inserting member supporting portion and the inner sealing portion so that a main body-side end portion of the inserting member supporting portion is displaceable when the inserting member swings.

Abstract: Catheter hubs having one or more wings where a front and rear of the wing rotationally offset in a circumferential direction.

Abstract: A catheter handle (1) includes handle body (2), and rotary member (3) being free to rotate with respect to the handle body (2) and connected to the wire. The handle body (2), in a planar view from a rotation axis direction of the rotary member (3), has second space (12) for the conductive wire is located from more distal side to more proximal side than first space (11) for the rotary member (3). The operating part (4) of the rotary member (3) is disposed on one side, and the second space (12) is disposed on another side, in the width direction of the handle (1). Length L1 from the center of the rotation axis to the rotary member (3) on the one side is longer than length L2 from the center of the rotation axis to the rotary member (3) on the another side.

Abstract: A medical device used to percutaneously gain access to a targeted site within a living body, for example the left ventricle of the heart. The device is comprised of an inner tubular member, outer tubular member, and an adjustable control handle. The control handle can precisely control the relative position of the inner tubular member relative to the outer member by providing feedback to the operator. This feedback provided by the control handle allows the operator to precisely maneuver the catheter within a body and change the shape of the catheter system without taking his/her eyes off the task that he/she is performing. The control handle is designed to precisely change the catheter system from one tip shape to another tip shape and back. Described herein is a method to perform a catheter tip shape change without the need to observe manipulations of a control system to change catheter tip configurations.

Abstract: A medical device used to percutaneously gain access to a targeted site within a living body, for example the left ventricle of the heart. The device is comprised of an inner tubular member, outer tubular member, and an adjustable control handle. The control handle can precisely control the relative position of the inner tubular member relative to the outer member by providing feedback to the operator. This feedback provided by the control handle allows the operator to precisely maneuver the catheter within a body and change the shape of the catheter system without taking his/her eyes off the task that he/she is performing. The control handle is designed to precisely change the catheter system from one tip shape to another tip shape and back. Described herein are methods to use such devices.

Abstract: Certain aspects relate to drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye. In several embodiments, the devices are capable of controlled release of two or more drugs, the release of each drug into a different ocular space (e.g., an ocular compartment versus an ocular fluid outflow pathway).

Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: A balloon catheter may include a shaft having a distal side and a proximal side and a balloon provided at the distal side of the shaft. The balloon may have a plurality of wings in a deflated state, with each of the wings having a projection on an outer surface in a wrapped state, and each of the projections having a projecting direction, which is opposite to a wrapping direction of the wing. In a cross section that is perpendicular to a long axis direction of the balloon, a base of the projection may have a base first end part farther from a tip of the wing and a base second end part closer to the tip of the wing, and a tip of the projection may be closer to a base of the wing with respect to a line passing through the base first end part which is perpendicular to a line passing through the base first end part and the base second end part.

Abstract: A non-surgical method of delivering a liquid radioactive solution from a source to a recipient comprising the steps of: determining a desired recipient level of radioactivity and recipient volume of the radioactive solution to be delivered to the recipient, providing a first valve having a waste position and a recipient position, providing a bolus conduit, a waste conduit and a recipient conduit, each conduit having a valve end being connected to said first valve, so that the first valve can establish a waste flow path in the waste position and a recipient flow path in the recipient position, the recipient flow path being different from said waste flow path, the bolus conduit comprising a measuring section and an internal volume, the internal volume being approximately equal to the desired recipient volume of the radioactive solution to be delivered to the recipient, arranging said first valve in the waste position, transporting a first amount of said radioactive solution through said waste flow path, the fir

Abstract: This passive safety device comprises an inner needle shield having a proximal end configured to be sealed to a tip of an injection device, a distal portion configured to be pricked by a needle in a pre-use position and pierced by the needle in an injection position, and an energy storage portion configured to accumulate energy as the passive safety device passes from the pre-use position to the injection position and release energy as the passive safety device passes from the injection position to a safety position. The passive safety device further comprises a sleeve surrounding the proximal end, an outer needle shield having a proximal end slidably attached to the sleeve so that the outer needle shield is movable relative to the sleeve, and a lock configured to lock the outer needle shield in the safety position.

Abstract: The present disclosure relates to systems and methods for controlling physiological glucose concentrations in a patient using a closed loop artificial pancreas. The systems and methods may utilize a controller with control logic operative to execute a multi-model predictive controller algorithm to determine a medication dose to the patient.