Abstract: Certain aspects relate to drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye. In several embodiments, the devices are capable of controlled release of two or more drugs, the release of each drug into a different ocular space (e.g., an ocular compartment versus an ocular fluid outflow pathway).

Abstract: A medical device used to percutaneously gain access to a targeted site within a living body, for example the left ventricle of the heart. The device is comprised of an inner tubular member, outer tubular member, and an adjustable control handle. The control handle can precisely control the relative position of the inner tubular member relative to the outer member by providing feedback to the operator. This feedback provided by the control handle allows the operator to precisely maneuver the catheter within a body and change the shape of the catheter system without taking his/her eyes off the task that he/she is performing. The control handle is designed to precisely change the catheter system from one tip shape to another tip shape and back. Described herein are methods to use such devices.

Abstract: A balloon catheter may include a shaft having a distal side and a proximal side and a balloon provided at the distal side of the shaft. The balloon may have a plurality of wings in a deflated state, with each of the wings having a projection on an outer surface in a wrapped state, and each of the projections having a projecting direction, which is opposite to a wrapping direction of the wing. In a cross section that is perpendicular to a long axis direction of the balloon, a base of the projection may have a base first end part farther from a tip of the wing and a base second end part closer to the tip of the wing, and a tip of the projection may be closer to a base of the wing with respect to a line passing through the base first end part which is perpendicular to a line passing through the base first end part and the base second end part.

Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: The present disclosure relates to systems and methods for controlling physiological glucose concentrations in a patient using a closed loop artificial pancreas. The systems and methods may utilize a controller with control logic operative to execute a multi-model predictive controller algorithm to determine a medication dose to the patient.

Abstract: This passive safety device comprises an inner needle shield having a proximal end configured to be sealed to a tip of an injection device, a distal portion configured to be pricked by a needle in a pre-use position and pierced by the needle in an injection position, and an energy storage portion configured to accumulate energy as the passive safety device passes from the pre-use position to the injection position and release energy as the passive safety device passes from the injection position to a safety position. The passive safety device further comprises a sleeve surrounding the proximal end, an outer needle shield having a proximal end slidably attached to the sleeve so that the outer needle shield is movable relative to the sleeve, and a lock configured to lock the outer needle shield in the safety position.

Abstract: A non-surgical method of delivering a liquid radioactive solution from a source to a recipient comprising the steps of: determining a desired recipient level of radioactivity and recipient volume of the radioactive solution to be delivered to the recipient, providing a first valve having a waste position and a recipient position, providing a bolus conduit, a waste conduit and a recipient conduit, each conduit having a valve end being connected to said first valve, so that the first valve can establish a waste flow path in the waste position and a recipient flow path in the recipient position, the recipient flow path being different from said waste flow path, the bolus conduit comprising a measuring section and an internal volume, the internal volume being approximately equal to the desired recipient volume of the radioactive solution to be delivered to the recipient, arranging said first valve in the waste position, transporting a first amount of said radioactive solution through said waste flow path, the fir

Abstract: Methods and systems are disclosed wherein temperature in a device such as an ambulatory infusion pump is monitored during inductive charging of the device such that temperature-sensitive contents or components, such as, for example, insulin, particular circuitry and/or other components are not damaged. Temperature can be monitored in the device at one or more locations during inductive charging. If the temperature breaches one or more predetermined thresholds and/or is rising at a rate greater than one or more predetermined thresholds, charging can be suspended or provided at reduced power to prevent the temperature from further rising and damaging the contents and/or components of the device. One or more alerts associated with these events may also be triggered so that the user is aware of the situation and may take corrective action.

Abstract: A delivery device for delivering a gel or liquid pharmaceutical to a treatment site, the delivery device including a body extending from a delivery tip, the body defining a cavity for retaining a pharmaceutical or a pre-assembled cartridge holding the pharmaceutical; and a driver for mechanically discharging the pharmaceutical from the cartridge to the delivery tip. The driver may be adapted to release a consistent flow of the pharmaceutical. In addition, the delivery device may be biased into a release configuration.

Abstract: A drug delivery device including: a body and a movable component arranged inside the body, a dosage selection and injection mechanism setting the position of the movable component inside the body depending on a selected dosage, a non-contact sensor configured to output signals indicative of the position of the movable component inside the body, and a processor. The processor is configured to receive the signals output from the non-contact sensor and to determine based on the signals whether the movable component is either in an initial position inside the body corresponding to no selected dosage or in a selected dosage position. Upon determining that the movable component has changed its position back from the selected dosage position to the initial position, the processor is configured to cause an indication to be output which informs a user regarding a dwell time of the drug delivery device.

Abstract: An intervertebral disc surgical system has at least one optical cannula configured with a working channel and an optical channel, wherein the working channel and the optical channel are positioned parallel to one another. The working channel is configured to receive the elongated tubular member of an electrosurgical instrument and the optical channel is configured to receive an optical scope. The optical cannula has an optical cannula operative end for entering an operative field of a patient.

Abstract: A Coude catheter insures proper drainage and reduces tissue damage by using a loop section having an open passageway positioned on a proximal end of the catheter to adjust the catheter.

Abstract: A medical device assembly may include a stylet having a distal stylet body and a proximal stylet hub, a cannula having a distal cannula body and a proximal cannula hub, and a lock for securing the stylet to the cannula, wherein the lock includes at least one abutment on at least one of the stylet hub and the cannula hub for restricting relative movement between the stylet hub and the cannula hub.

Abstract: A needleless injector pressurizes a substance to be injected having an ejection pressure defined as a pressure of the substance to be injected ejected through an ejection port. The ejection pressure is raised to a first peak pressure after pressurizing is started, is lowered to a pressure lower than the first peak pressure afterward, and then is raised to a second peak pressure again. An on-completion reached depth that is an on-completion reached depth of the substance when the pressurizing portion completes pressurizing is adjustable, the on-completion reached depth being increased along with increase of the first peak pressure and being increased along with reduction of a length between peaks from a first timing at which the ejection pressure reaches the first peak pressure to a second timing at which the ejection pressure reaches the second peak pressure.

Abstract: The present invention provides a power unit (1) for a drug delivery device as well as methods for providing and mounting the power unit (1) in the drug delivery device. The power unit (1) comprises a first interface member (30) extending along a reference axis and comprising a hollow body (31) and a first engagement structure (35), a second interface member (10) comprising a tubular structure (11) extending at least partially through the hollow body (31) and having a skirt (12), and a second engagement structure (14) configured for releasable engagement with the first engagement structure (35), and a torsion spring (20) comprising a first end portion (23) being attached to the first interface member (30) and a second end portion (22) being attached to the second interface member (10), the torsion spring (20) being pre-strained to induce a relative rotational motion between the first interface member (30) and the second interface member (10).

Abstract: A part of a device for injecting a liquid product having an end sleeve and a syringe support which is able to move with respect to the end sleeve. The syringe support is designed to bear an injection syringe fitted with a removable protective cap. A deformable ring is kinematically connected to the syringe support. This ring can be deformed elastically between a configuration which is designed to axially immobilize the injection syringe in the syringe support, and a configuration designed to allow the protective cap to pass through the deformable ring.

Abstract: A drug delivery device comprising a delivery unit (2) including an internal reservoir (8), a subcutaneous delivery mechanism (6), a pump for pumping liquid from the internal reservoir to the subcutaneous delivery system, and a liquid filling mechanism (12) configured for injecting liquid from an external vial (16) or reservoir into the internal reservoir. The liquid filling mechanism comprises a filling port (14) and a valve mechanism (18) selectively operable to: open a first fluid path (54) extending from the filling port to the internal fluid reservoir and close a second fluid path (56) extending from the internal reservoir to the subcutaneous delivery member, or close the first fluid path and open the second fluid path.

Abstract: The present disclosure relates to a subcutaneous fixation system for fixing medical devices, in particular catheters, and keeping them in position with respect to an access point on the skin of a patient.

Abstract: A method of treating soft tissue conditions. A harvesting device is provided. The harvesting device is operably connected to a tissue processing device using tubing. An aperture is formed in a bone. The bone has an interior. The harvesting device is inserted through the aperture in the bone and into the interior of the bone. The harvesting device is manipulated to dissociate connective tissue progenitor cells in the interior of the bone. Tissue is aspirated from the interior of the bone. The connective tissue progenitor cells are separated from the aspirated tissue. The separated connective tissue progenitor cells are injected in a region of a body that is experiencing a soft tissue condition to treat the soft tissue condition.

Abstract: An elastomeric pump having at least one sensor for sensing changes in elongation of a bladder of the pump is provided. Also provided is an infusion assembly including an elastomeric pump having a bladder, at least one sensor for sensing changes in elongation of the bladder, and an indicator for providing one or more outputs of the sensor. The sensor may be a flexible sensor positioned in contact with the bladder of the pump, or a dielectric material may be incorporated into the material the bladder is made from such that the dielectric elastomer material of the bladder forms the sensor.