Abstract: Methods for making thebaine and an acid salt of thebaine are disclosed herein. In one embodiment, an acid salt of thebaine is made from codeinone or an acid salt of one or more of the following: 8-methoxy-?6-dihydrothebaine, codeinone dimethyl ketal, and neopinone dimethyl ketal.
Type:
Grant
Filed:
November 25, 2003
Date of Patent:
October 25, 2005
Assignee:
Euro-Celtique S.A.
Inventors:
Robert J. Kupper, Arie Gutman, Igor Rukhman, Lev Yudovich, Gennady A. Nisnevich
Abstract: A composition of L-ascorbic acid derivatives is described comprising L-ascorbic acid and lysine or lysine moieties, wherein L-ascorbic acid is covalently bound to the lysine or lysine moieties. The composition so described is used to prevent the degradation of extracellular matrix, stabilize connective tissue, is used to as an antioxidant, and is used for treating damage to skin comprising applying the topical composition to the skin.
Type:
Grant
Filed:
August 23, 2002
Date of Patent:
March 8, 2005
Inventors:
Waheed M. Roomi, Shrirang Netke, Vadim Ivanov, Aleksandra Niedzwiecki, Matthias Rath
Abstract: The present invention provides novel phosphonic acid diester derivatives useful as medicines. The phosphonic acid diester derivatives
are represented by the general formula:
wherein R1 represents amino group, N-lower alkylamino group, N-lower alkenylamino group, or the like;
R2 and R3 represent hydrogen atom, lower alkyl group, halogen atom, lower alkoxy group, or the like;
R4 represents hydrogen atom, lower alkyl group or phenyl(lower)alkyl group;
R5 and R6 represent lower alkyl group;
X, Y and Z represent that all of them are carbon atoms or one of them is nitrogen atom and the other two are carbon atoms;
Q represents a single bond or alkylene group;
or the pharmacologically acceptable salts thereof.
Abstract: A method for producing compounds of the general formula (I)
in which R is a linear or any branched (C1-C18) alkyl group, from compounds of the general formula (II)
that are reacted in the presence of hydrogen cyanide or a precursor producing hydrogen cyanide in situ and of catalytic amounts of base. The presence of another polar solvent is not necessary. Compounds of formula (I) are important intermediates for perfumes and aromatic substances.
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