Abstract: A process for the manufacture of ?-Difluoromethylornithine, analogs and derivatives is described from ornithine hydrochloride or from N?-phthaloyl ornithine hydrochloride, conversion to an alkyl ester, conversion to solid derivatives through the formation of Schiff bases, subsequent halomethylation using suitable bases and hydrolysis.
Type:
Grant
Filed:
September 5, 2002
Date of Patent:
February 14, 2006
Assignee:
Sabinsa Corporation
Inventors:
Muhammed Majeed, Kalyanam Nagabhushanam, Keshava Rao Rapole, Ravikrishna Chebolu