Patents Examined by Taofiq A. Solola
  • Patent number: 10894224
    Abstract: A system and method for removing undesirable organic compounds so that the desirable cannabinoids, terpenes, and any other beneficial organic compounds can be easily and effectively captured is provided herein. The system and method makes use of diatomaceous earth filters through which a solution containing the organic compounds is rinsed with liquid non-polar solvent. The undesirable components remain in the diatomaceous while the beneficial organic compounds pass through and are collected in a liquid solution.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: January 19, 2021
    Inventor: Caleb Mata
  • Patent number: 10894033
    Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: January 19, 2021
    Assignees: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: Liming Shao, John Emmerson Campbell, Michael Charles Hewitt, Una Campbell, Taleen G. Hanania
  • Patent number: 10888550
    Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R7, G1 and G2, are defined herein.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: January 12, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Tianbao Lu, Peter J. Connolly, Maxwell David Cummings, Gaston Stanislas Marcella Diels, Jan Willem Thuring, Ulrike Philippar, James Patrick Edwards, Didier Jean-Claude Berthelot, Tongfei Wu
  • Patent number: 10889717
    Abstract: The present disclosure provides composition having at least one leuco composition conforming to Formula (I): Ar1Ar2Ar3CH??(I) wherein Ar2 and Ar3 are independently a carbocyclic aryl or heteroaryl, and Ar1 is selected from the group consisting of: unsubstituted phenyl, electron deficient carbocyclic aryl, and heteroaryl. The present disclosure also provides a method of detecting an authentic composition and test kits for detecting authentic compositions.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: January 12, 2021
    Assignee: Milliken & Company
    Inventors: Sanjeev K. Dey, Haihu Qin, Gregory S. Miracle
  • Patent number: 10875834
    Abstract: Prodrugs and derivatives of 5-hydoxymethyl-2-furfural (5-HMF) with protected or modified aldehyde and/or alcohol moieties are provided. The prodrugs or derivatives exhibit increased bioavailability, e.g. due to having extended half-lives in circulation. The drugs are therefore administered i) at lower doses and/or ii) less frequently than 5-HMF, while still maintaining the beneficial therapeutic effects of 5-HMF.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: December 29, 2020
    Assignees: Virginia Commonwealth University, The Children's Hospital of Philadelphia
    Inventors: Martin K. Safo, Guoyan Xu, Yan Zhang, Osheiza Abdulmalik
  • Patent number: 10875853
    Abstract: Provided are a (hetero)arylamide compound as shown in formula (I) having an inhibitory effect on protein kinase activity, a pharmaceutically acceptable salt, a stereoisomer, a solvate or hydrate thereof, a pharmaceutical composition including the compound or a derivative thereof, and a method for preparing the compound. The compound can be used as an irreversible inhibitor for protein kinase, for preparing a plurality of drugs including an anti-tumour drug.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: December 29, 2020
    Assignee: Shenzhen TargetRx, Inc.
    Inventors: Yihan Wang, Jiuyang Zhao, Yixin Ai
  • Patent number: 10851050
    Abstract: The present disclosure discloses a biaryl urea ROR?t inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an ROR?t inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an ROR?t-related disease.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: December 1, 2020
    Inventors: Yonghui Wang, Yafei Huang, Fazhi Yu, Ting Tang
  • Patent number: 10851095
    Abstract: The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving elevated levels of aldosterone or abnormal or excessive fibrosis, such as kidney disease and hypertension.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: December 1, 2020
    Inventors: Bijoy Panicker, Lambertus J. W. M. Oehlen
  • Patent number: 10844081
    Abstract: Disclosed are a range of protected organoboronic acid reagents useful in the modular assembly of complex organic compounds. The reactivities of the protected organoboronic acid reagents may be varied predictably by changes to the number and identities of their substituents. Also disclosed are methods of using the protected organoboronic acid reagents in the synthesis of organic compounds.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: November 24, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Michael Schmidt, Greg Morehouse, Robert W. Pipal
  • Patent number: 10836760
    Abstract: The invention provides compositions and methods for the treatment of presbyopia. The methods preferably comprise storing an aceclidine composition in a container having a headspace at a temperature from about 2 to about 8 degrees Celsius. The methods further comprise filling the container under an inert gas overlay and/or enclosing the container an anti-leaching material or disposing the container in a second container containing an anti-leaching material.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: November 17, 2020
    Assignee: Presbyopia Therapies LLC
    Inventor: Gerald Horn
  • Patent number: 10836748
    Abstract: The invention relates to a compound according to general formula (I), which acts as a bradykinin (BK) B2 receptor antagonist; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: November 17, 2020
    Assignee: Pharvaris Netherlands B.V.
    Inventors: Christoph Gibson, Joern Saupe, Horst-Dieter Ambrosi, Lars Ole Haustedt
  • Patent number: 10836776
    Abstract: The present application relate to process for preparation of tetrahydrofuran compound of formula II, 4-Methylene tetrahydrofuran compound of formula V and tetrahydropyran compound of formula IX which are useful as intermediates for the preparation of halichondrin B analogues such as Eribulin or its pharmaceutically acceptable salts.
    Type: Grant
    Filed: November 23, 2017
    Date of Patent: November 17, 2020
    Inventors: Kumar Sarvesh, Debjit Basu, Raja gopal Penumandla, Prapulla Kumar Palvai
  • Patent number: 10822324
    Abstract: The present invention relates to a method for selectively separating propylene carbonate by adding water to reaction products comprising a polyether carbonate polyol and propylene carbonate, which are generated from a polymerization reaction of propylene oxide and carbon dioxide under a double metal cyanide (DMC) catalyst, wherein an economical and effective separation of propylene carbonate can be achieved.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: November 3, 2020
    Inventors: Joon-Hyun Baik, Jae-Hee Ha
  • Patent number: 10815245
    Abstract: The present invention relates to the production of xylene derivatives from furfural and its derivatives. The invention describes new routes for converting furfural and its derivatives into xylene derivatives including novel intermediates.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: October 27, 2020
    Inventors: Didier Morvan, Olivier Back, Raphaƫl Wischert, Eric Muller
  • Patent number: 10807981
    Abstract: The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride has Btk-selective inhibitory activity and, in addition to having excellent metabolic stability, it is a compound that exhibits a high level of solubility and absorption with respect to the free base and can be crystallized, hence it can serve as a therapeutic agent for diseases involving B cells and mast cells.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: October 20, 2020
    Inventors: Shingo Yamamoto, Toshio Yoshizawa
  • Patent number: 10800809
    Abstract: The present invention relates to an improved process for the preparation of carfilzomib or a pharmaceutically acceptable salt thereof. The present invention also relates to a process for the preparation of amorphous form of carfilzomib.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: October 13, 2020
    Assignee: Laurus Labs Limited
    Inventors: Sanjay Kumar Dehury, Nagaraju Mekala, Jahangeer Baba Shaik, Srinivasa Rao Buddepu, Lakshmi Kanth Kola, Venkata Sunil Kumar Indukuri, Seeta Rama Anjaneyulu Gorantla, Satyanarayana Chava
  • Patent number: 10793590
    Abstract: Compounds of formula (I) or formula (II), compositions and methods useful for treating and/or preventing a fungal infections are provided. wherein the substituents are as defined in the appended claims.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: October 6, 2020
    Assignees: President and Fellows of Harvard College, Wisconsin Alumni Research Foundation, Universidad de Costa Rica
    Inventors: Ethan Van Arnam, Clarissa Sit, Antonio Ruzzini, Jon Clardy, Cameron Currie, Adrian Alberto Pinto-Tomas
  • Patent number: 10793524
    Abstract: Provided is a method for regenerating an aromatic amide compound into a corresponding aromatic nitrile compound, the method realizing a dehydration reaction of providing a target compound selectively at a high yield, with generation of a by-product being suppressed. Also provided is a method for producing an aromatic nitrile compound that decreases the number of steps of the dehydration reaction and significantly improves the reaction speed even at a pressure close to normal pressure. In addition, the above-described production method is applied to a carbonate ester production method to provide a method for producing a carbonate ester efficiently. The above-described methods are realized by a method for producing an aromatic nitrile compound including a dehydration reaction of dehydrating an aromatic amide compound, in which the dehydration reaction uses, as a solvent, any of 1,2-dimethoxybenzene, 1,3-dimethoxybenzene and 1,3,5-trimethoxybenzene.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: October 6, 2020
    Inventors: Hidefumi Harada, Yousuke Shinkai, Hongyu Liu, Takehiko Isobe, Yoshinori Isahaya
  • Patent number: 10792584
    Abstract: A process for producing THC-O-acetate using a succession of distillation, salting-out assisted liquid-liquid extractions (SALLEs), and solvent recovery techniques. Tetrahydrocannabinol (THC) in cannabis oil reacts with acetic anhydride under reflux to produce THC-O-acetate and acetic acid. The resulting crude product is distilled and subjected to a SALLE with hexane followed by a SALLE with petroleum ether, before being distilled again in order to obtain a refined, THC-O-acetate product.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: October 6, 2020
    Assignee: Nextleaf Solutions Ltd.
    Inventors: Krupal Devendra Pal, Ryan Delmoral Ko, Brock Aston Hughes, Ivan Jason Casselman
  • Patent number: 10787442
    Abstract: Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: September 29, 2020
    Inventors: John G. Catalano, Martha Alicia De La Rosa, Wieslaw Mieczyslaw Kazmierski, Vicente Samano