Patents Examined by Taofiq A. Solola
  • Patent number: 12029217
    Abstract: Disclosed herein are safened compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt or ester thereof and (b) a safener comprising isoxadifen or agriculturally acceptable salt or ester thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt or ester thereof and (b) a safener comprising isoxadifen or agriculturally acceptable salt or ester thereof.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: July 9, 2024
    Assignee: Corteva Agriscience LLC
    Inventors: Norbert M. Satchivi, Jeremy Kister
  • Patent number: 12029723
    Abstract: The invention provides safe and efficacious treatments for Female Sexual Disorders, genitopelvic pain/penetration disorders; vulvovaginal atrophy, vestibulodynia, dyspareunia, sexual interest/arousal disorder, low female libido, and female orgasmic disorder.
    Type: Grant
    Filed: July 18, 2022
    Date of Patent: July 9, 2024
    Assignee: GTO PHARMA, LLC.
    Inventor: Wendy Anne Epstein
  • Patent number: 12017993
    Abstract: Methods for preparing 5-fluoro-6-(bromo or chloro)picloram analogs, or derivatives thereof, from picloram acid, picloram ester, or the nitrile analog of picloram are provided. The methods include chemical process steps that: (1) introduce a phthaloyl group onto the 4-amino substituent of picloram acid, picloram ester, or the nitrile analog of picloram, (2) add 2 fluorine atoms at the 5,6-positions of the pyridine ring using halex fluorination chemistry, (3) remove the phthaloyl group, hydrolyze the ester or nitrile substituent, and add chlorine or bromine to the 6-position by treatment with an acid and water, and finally, (4) esterify the 5-fluoro-6-(bromo or chloro)picloram acid produced in step (3) to a 5-fluoro-6-(bromo or chloro)picloram ester.
    Type: Grant
    Filed: June 23, 2022
    Date of Patent: June 25, 2024
    Assignee: CORTEVA AGRISCIENCE LLC
    Inventors: Jayachandran Devaraj, Nugzar Ghavtadze, Nicholas M. Irvine, Jeremy Kister, Melissa Lee, Ronald B. Leng, Rongrong [Mandy] Lin, Rong Ling, Noormohamed M. Niyaz, Abraham D. Schuitman, Aaron A. Shinkle, Siyu Tu, Gregory T. Whiteker, Chunming Zhang
  • Patent number: 12012416
    Abstract: A method of improving skin health and condition comprising the application of select isohexides to the skin.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: June 18, 2024
    Assignee: Sytheon Ltd
    Inventor: Ratan K Chaudhuri
  • Patent number: 12012418
    Abstract: The present invention is generally directed towards compounds capable of binding the aryl hydrocarbon receptor and modulating its activity, methods of treating inflammatory conditions such as Crohn's disease using such compounds, and pharmaceutical compositions comprising such compounds. Also provided are methods of increasing levels of IL-22 in a subject and/or decreasing levels of IFN-? in a subject.
    Type: Grant
    Filed: July 7, 2022
    Date of Patent: June 18, 2024
    Assignee: Nogra Pharma Limited
    Inventors: Francesca Viti, Salvatore Bellinvia, Salvatore Demartis
  • Patent number: 12006324
    Abstract: Disclosed herein is a specific method of preparation of Trilaciclib. The said method is to provide an efficacy of a protection free synthetic method of Trilaciclib with less steps and good yields.
    Type: Grant
    Filed: December 19, 2022
    Date of Patent: June 11, 2024
    Assignee: CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO. LTD.
    Inventors: Satyanarayana Kamani, Hsin-Yun Chang, Tzu-Chiang Lu, Chin-Cheng Mai
  • Patent number: 11999731
    Abstract: Provided herein are compounds that modulate EGFR and methods of using the same, for example to treat cancer.
    Type: Grant
    Filed: May 9, 2022
    Date of Patent: June 4, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Mukesh K. Nyati, Theodore S. Lawrence, Christopher Whitehead, Jason Christopher Rech, Brennan Taylor Watch
  • Patent number: 11993577
    Abstract: Provided herein is a process for the preparation of 3,4-methylenedioxymethamphetamine, (R)-3,4-methylenedioxymethamphetamine and (S)-3,4-methylenedioxymethamphetamine.
    Type: Grant
    Filed: September 1, 2022
    Date of Patent: May 28, 2024
    Assignee: EmpathBio, Inc.
    Inventors: Majed Fawaz, Nicholas Morra
  • Patent number: 11993562
    Abstract: The invention provides a plurality of methods which may be employed as a single method or a plurality of sequential method steps in the isolation and purification of Cannabidiol from Hemp plants. It also provides methods for having a terpene-rich fraction as a byproduct of the method. Depending upon the ultimate objective, the individual method components may be used separately or combined with one or more method steps to accomplish the objectives.
    Type: Grant
    Filed: March 31, 2022
    Date of Patent: May 28, 2024
    Assignee: RJ LEE GROUP, INC.
    Inventors: Alan M. Levine, Steven J. Monaco, Richard J. Lee, Duane M. Erickson
  • Patent number: 11986810
    Abstract: A 4,4?-divinylazoarylene-bridged diruthenium complex with a general formula [{Ru(CO)(L-?2[N,S]?)(PiPr3)2}2(?—{CH?CH—C6H2—(iPr)2-2,6}2—N?N-4,4?)], its synthesis, and its use as an catalyst in inorganic processes.
    Type: Grant
    Filed: January 5, 2024
    Date of Patent: May 21, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventor: Obadah Subhi Abdel-Rahman
  • Patent number: 11981679
    Abstract: The present disclosure relates to a series of tricyclic compounds, their tautomers, polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by adenosine receptor (AR) activity. The disclosure also relates to process of preparation of these tricyclic compounds of Formula I. These compounds are useful in the treatment, prevention or suppression of diseases and disorders that may be susceptible to improvement by antagonism of the adenosine receptor. The disclosure also relates to the process of preparation of the tricyclic compounds, and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 9, 2022
    Date of Patent: May 14, 2024
    Assignee: IMPETIS BIOSCIENCES LTD.
    Inventors: Sujay Basu, Sachin Thorat, Yogesh Shejul, Anil Panmand, Meena Patel, Goraksha Khose, Rajesh Bonagiri, Dinesh Barawkar, Bheemashankar Kulkarni, Kasim Mookhtiar
  • Patent number: 11981793
    Abstract: An ultraviolet radiation absorbing composition can be used as a light stabilizer for a shaped artificial polymer article, wherein the polymer is a synthetic polymer and/or a natural elastomer and wherein the ultraviolet radiation absorbing composition includes the compound of formula (I) wherein n and m are independently 0 to 20, and at least one of m and n being ?1; and X1, X2, X3, X4 and X5 are the same or different and are independently selected from H, C(O)R1 with R1 being C8-C24-alkyl, or a group of the general formula (II) wherein R2 is H or halogen.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: May 14, 2024
    Assignee: BASF SE
    Inventors: Thomas Ehlis, Heinz Herbst, Daniel Mueller, Manuele Vitali, Gregor Huber
  • Patent number: 11975312
    Abstract: A 4,4?-divinylazoarylene-bridged diruthenium complex bearing two Ru(CO)(2-mercaptoquinolato)(PiPr3)2 moieties, its synthesis, and its use as a catalyst.
    Type: Grant
    Filed: January 10, 2024
    Date of Patent: May 7, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventor: Obadah Subhi Abdel-Rahman
  • Patent number: 11974981
    Abstract: Methods and compositions are provided for treating endometriosis in an individual, and the pain associated with endometriosis. Aspects of the methods include administering to the individual an agent that promotes ALDH activity.
    Type: Grant
    Filed: February 25, 2022
    Date of Patent: May 7, 2024
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eric Gross, Daria Mochly-Rosen, Stacy Lynn McAllister
  • Patent number: 11970451
    Abstract: An 6-(3-hydroxyphenyl)-2-methoxy-4-(3-methylphenyl)nicotinonitrile compound, its synthesis, and its use as an antimicrobial agent.
    Type: Grant
    Filed: December 7, 2023
    Date of Patent: April 30, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed
  • Patent number: 11963956
    Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: April 23, 2024
    Assignee: FORMA Therapeutics, Inc.
    Inventors: Patrick F. Kelly, Susan Ashwell, Blythe Thomson, Alan Collis, Jeff Davis, Duncan Walker, Wei Lu
  • Patent number: 11957671
    Abstract: This invention pertains to the prevention and treatment of aging-associated disease. The invention relates to the use of benzodioxane inhibitors of leukotriene production through modulation of leukotriene A4 hydrolase (“LTA4H”) to treat and/or prevent conditions associated with aging such as cognitive disorders, motor disorders, and neuroinflammation.
    Type: Grant
    Filed: October 31, 2022
    Date of Patent: April 16, 2024
    Assignee: Alkahest, Inc.
    Inventors: Meghan Kerrisk Campbell, Eva Czirr, Reema Harish
  • Patent number: 11952495
    Abstract: The present disclosure provides for compounds of Formula (I), its corresponding compounds of Formula (II) or salts thereof and their use as fluorogenic pH sensors.
    Type: Grant
    Filed: October 11, 2021
    Date of Patent: April 9, 2024
    Assignee: Life Technologies Corporation
    Inventors: Yi-Zhen Hu, Aimei Chen, Daniel Beacham, Chrisgen Vonnegut, Krishnamurthy Nacharaju
  • Patent number: 11945827
    Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: April 2, 2024
    Assignee: The Johns Hopkins University
    Inventors: Jun Liu, Sam Hong, Brett R. Ullman, Joseph E. Semple, Kana Yamamoto, Puneet Kumar, Magesh Sadagopan, Jennifer C. Schmitt
  • Patent number: 11939312
    Abstract: Provided are enantiomers of MDMA, such as R-MDMA and S-MDMA, and non-racemic mixtures thereof. In some embodiments, the provided mixtures comprise R-MDMA in enantiomeric excess. In other aspects, provided are methods of making such enantiomers and non-racemic mixtures, compositions thereof, and methods of using the same. In some aspects, features of the provided mixtures, compositions, and methods include improved pharmacokinetics, reduced toxicity, such as neurotoxicity, and a reduced potential for abuse. In some embodiments, improved pharmacokinetics include a reduced duration of action. In some embodiments, reduced toxicity and abuse potential result from distinct binding profiles compared to racemic MDMA, R-MDMA, or S-MDMA.
    Type: Grant
    Filed: August 3, 2023
    Date of Patent: March 26, 2024
    Assignee: Arcadia Medicine, Inc.
    Inventor: Nikita Obidin