Patents Examined by Taofiq A. Solola
  • Imidazolepyridine compounds and uses thereof
    Patent number: 10676479
    Abstract: A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R3, R4, R6, and R7 are as defined herein.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: June 9, 2020
    Assignee: Novartis AG
    Inventors: Ho Man Chan, Xingnian Fu, Xiang-Ju Justin Gu, Ying Huang, Ling Li, Yuan Mi, Wei Qi, Martin Sendzik, Yongfeng Sun, Long Wang, Zhengtian Yu, Hailong Zhang, Ji Yue Zhang, Man Zhang, Qiong Zhang, Kehao Zhao
  • Amide-sulfamide derivatives, compositions, and uses related to CXCR4 inhibition
    Patent number: 10669270
    Abstract: This disclosure relates amide-sulfamide compounds disclosed herein and uses related to CXCR4 inhibition. In certain embodiments, the compounds have formula I, salts, derivatives, and prodrugs thereof wherein, A is a bridging aryl or heterocyclyl and R1 and R2 are further disclosed herein. In certain embodiments, the disclosure contemplates pharmaceutical compositions comprising compounds disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing CXCR4 related diseases or conditions by administering an effective amount of a compound disclosed herein to a subject in need thereof.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: June 2, 2020
    Assignee: Emory University
    Inventors: Hyunsuk Shim, Qi Shi, Renren Bai
  • Process for preparing methoxy methyl pyridine dicarboxylate
    Patent number: 10669254
    Abstract: The present invention provides a process for preparing a compound of the formula (I): wherein each occurrence of R1 is a C1-C4 alkyl; and R2 is C1-C4 alkyl.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: June 2, 2020
    Assignee: ADAMA AGAN LTD.
    Inventors: Tzurit Kusneic, Omer Tzor, Avihai Yacovan
  • Combining electronic monitoring with inhaled pharmacological therapy to manage cardiac arrhythmias including atrial fibrillation
    Patent number: 10660578
    Abstract: Disclosed herein are methods of treating cardiac arrhythmia with electronic monitoring in a timely manner. Also disclosed herein are systems for electronic monitoring of cardiac arrhythmia.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: May 26, 2020
    Assignee: InCarda Therapeutics, Inc.
    Inventors: Rangachari Narasimhan, Luiz Belardinelli, Carlos A. Schuler
  • Synthesis and composition of rapafucin libraries
    Patent number: 10662220
    Abstract: A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: May 26, 2020
    Assignee: The Johns Hopkins University
    Inventors: Jun Liu, Jingxin Wang, Zufeng Guo, Sam Hong, Wukun Liu, Hanjing Peng, Manisha Das
  • Biaryl urea derivative or salt thereof and preparation process and use for the same
    Patent number: 10647665
    Abstract: The present invention discloses a biaryl urea ROR?t inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an ROR?t inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an ROR?t-related disease.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: May 12, 2020
    Assignee: Fudan University
    Inventors: Yonghui Wang, Yafei Huang, Fazhi Yu, Ting Tang
  • Process for preparing 2-(1-(tert-butoxycarbonyl)piperidine-4-yl)benzoic acid
    Patent number: 10640467
    Abstract: The invention relates to processes for preparing 2-(1-(tert-butoxycarbonyl)-piperidine-4-yl)benzoic acid having formula I: Among its various uses, this compound is useful as an intermediate for preparing ampreloxetine and salts thereof.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: May 5, 2020
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Miroslav Rapta, Dimitar Filipov
  • 9,10-?,?-OH-taxane analogs and methods for production thereof
    Patent number: 10639293
    Abstract: The present invention relates to a method for the treatment of cancer in a cancer patient.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: May 5, 2020
    Assignee: Tapestry Pharmaceuticals, Inc.
    Inventors: Jan Zygmunt, James Ferrara, James D. McChesney
  • Compound and intermediate thereof
    Patent number: 10640456
    Abstract: A compound represented by the following general formula (I): (the symbols in the general formula (I) are as described in the Description), wherein the compound contains one or more structures selected from the following (i) and (ii): (i) “A” is an aliphatic hydrocarbon group containing two or more alicyclic hydrocarbon groups, containing a saturated aliphatic hydrocarbon group at a terminal position directly bound to “N”, and optionally containing O, S, N in a carbon chain (ii) at least one of R2, R3, R4 and R5 is a cycloalkyl group optionally containing a substituent group or an aryl group optionally containing a substituent group.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: May 5, 2020
    Assignees: DAI NIPPON PRINTING CO., LTD., YAMAMOTO CHEMICALS, INC.
    Inventors: Masato Okada, Takafumi Yoshida, Satoshi Kinoshita
  • Heterocyclic derivatives and use thereof
    Patent number: 10633394
    Abstract: A heterocyclic derivative represented by formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, which has an inhibitory effect on the activation of STAT3 protein, and is useful for the prevention or treatment of diseases associated with the activation of STAT3 protein.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: April 28, 2020
    Assignee: C&C RESEARCH LABORATORIES
    Inventors: Chan Hee Park, Sang Hwi Lee, Junhwan Im, Soon Ok Lee, Jungsook Kim, Heon Kyu Park, Jee Hun Yun, Kwang Seok Ko, Hye Jung Kim, Byungho Kim, Mi Sun Kim, Minjung Kong, Hyung Jo Moon
  • GPR120 agonists for the treatment of type II diabetes
    Patent number: 10618893
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, G, and Q are defined herein; and wherein R11, R21, R41, RB1 and G1, are defined herein.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: April 14, 2020
    Assignee: JANSSEN PHARMACEUTICALS NV
    Inventors: Zhihua Sui, Chaozhong Cai, Xuqing Zhang
  • Pyridinol derivative or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient
    Patent number: 10604487
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating inflammatory bowel disease, containing, as an active ingredient, a pyridinol derivative or a pharmaceutically acceptable salt thereof. A pyridinol derivative represented by chemical formula 1 or a pharmaceutically acceptable salt thereof has an excellent colitis inhibitory effect in an inflammatory bowel disease model, and thus can be useful as a medicine for preventing or treating inflammatory bowel disease.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: March 31, 2020
    Assignees: Research Cooperation Foundation of Yeungnam University, Industry-University Cooperation Foundation Hanyang University Erica Campus
    Inventors: Byeong-Seon Jeong, Jung-Ae Kim, Tae-gyu Nam
  • Energy storage molecular material, crystal dielectric layer and capacitor
    Patent number: 10597407
    Abstract: The present disclosure provides an energy storage molecular material, crystal dielectric layer and capacitor which may solve a problem of the further increase of volumetric and mass density of reserved energy associated with some energy storage devices, and at the same time reduce cost of materials.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: March 24, 2020
    Assignee: CAPACITOR SCIENCES INCORPORATED
    Inventor: Pavel Lazarev
  • Organic compound, crystal dielectric layer and capacitor
    Patent number: 10600574
    Abstract: The present disclosure provides an organic compound characterized by electronic polarizability and having a following general structural formula: where Core is an aromatic polycyclic conjugated molecule, R1 is an insulating group, n is 1, 2, 3, 4, 5, 6, 7 or 8, R2 is substitute located in apex positions, R3 and R4 are located in side (lateral) positions and, the core has flat anisometric form and R2 are selected from hydrogen and nucleophilic groups (donors) and R3 and R4 are independently selected from hydrogen and electrophilic groups (acceptors) or vice versa R3 and R4 are independently selected from hydrogen and nucleophilic groups (donors) and R2 are selected from hydrogen and electrophilic groups (acceptors).
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: March 24, 2020
    Assignee: CAPACITOR SCIENCES INCORPORATED
    Inventors: Paul Furuta, Pavel Ivan Lazarev
  • Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
    Patent number: 10590104
    Abstract: Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of making the polymorphic forms and methods of their use are also disclosed.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: March 17, 2020
    Assignee: Celgene Corporation
    Inventors: Markian S. Jaworsky, Roger Shen-Chu Chen, George W. Muller
  • Mercaptopurine hemihydrate
    Patent number: 10590137
    Abstract: Provided herein is a new mercaptopurine form, as a hemihydrate, and methods of making and using the same.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: March 17, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Adam J. Matzger, Kortney Kersten
  • Aminothiazole derivatives useful as antiviral agents
    Patent number: 10590094
    Abstract: The invention relates to novel compounds of the Formula (I), to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: March 17, 2020
    Assignee: Innovative Molecules GmbH
    Inventors: Gerald Kleymann, Christian Gege
  • Benzo[b]furans as bromodomain inhibitors
    Patent number: 10583112
    Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: March 10, 2020
    Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
    Inventors: Stephen John Atkinson, Emmanuel Hubert Demont, Lee Andrew Harrison, Alexander G. Preston, Jonathan Thomas Seal, Ian David Wall, Robert J. Watson, James Michael Woolven
  • Method for preparing 2-chloro-6-trichloromethylpyridine through liquid phase photochlorination of 2-methylpyridine
    Patent number: 10577326
    Abstract: The present invention relates to a method for preparing 2-chloro-6-trichloromethylpyridine with product purity greater than or equal to 99.0% by using trifluoromethyl chlorobenzene as a solvent for reaction between 2-methylpyridine with chlorine gas, in which 2-methylpyridine and chlorine gas are used as starting materials, trifluoromethyl chlorobenzene is used as a solvent, 2-methylpyridine is prepared into a liquid raw material by using the solvent trifluoromethyl chlorobenzene, and the liquid raw material is continuously fed to perform liquid phase photochlorination reaction at temperature of 160-240° C. under irradiation of ultraviolet light to obtain 2-chloro-6-trichloromethylpyridine solution.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: March 3, 2020
    Assignee: Zhejiang Avilive Chemical, Co., Ltd.
    Inventors: Huiyue Li, Keqiang Jin, Jiaquan Zhu
  • Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
    Patent number: 10577345
    Abstract: Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde (also referred to herein as Compound (I)) and intermediates used in such processes. Compound (I) binds to hemoglobin and increases it oxygen affinity and hence can be useful for the treatment of diseases such as sickle cell disease.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: March 3, 2020
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Zhe Li, Nathan Guz, Yiyang Shao, Julieana Cocuz, Markus Frieser, George Petros Yiannikouros, Liang Liao