Abstract: A medical injection system adapted for a single-handed injection, the medical injection device comprising a gas compartment configured to contain a gas, the gas compartment comprising a piston, a reservoir intended to contain a drug composition, the reservoir having a proximal portion and a distal portion provided with a fluid exit configured to receive an injection needle, wherein the piston can move proximally between a distal position defining a first volume of the gas compartment to a proximal position defining a second volume of the gas compartment smaller than the first volume, and wherein the gas compartment is in gas communication with the reservoir in order to force the drug composition through the fluid exit, when the piston is moved proximally.

Abstract: A microneedle container includes a housing that houses a microneedle and a cover that covers the microneedle. The microneedle includes a base having a first surface on which a projection is formed and a second surface supported by a supporting portion of the housing. The base has an abutted portion on the first surface where the projection is not formed, and the cover has an abutment portion that faces the abutted portion, and a facing portion that faces the projection. A distance between the abutment portion and the facing portion is larger than that between the abutted portion and a distal end of the projection in a direction in which the projection extends. A distance between the abutment portion and the supporting portion is smaller than a sum of a distance between the abutted portion and the second surface and a distance between the abutted portion and the distal end.

Abstract: There is provided drug delivery devices including a drug container assembly with a needle and automatic needle insertion and drug delivery mechanisms. Aspects of the devices described include a noise-generation mechanism to indicate the completion of drug delivery, a mechanism for triggering drug delivery following needle insertion, front-end activation of the device and a safety mechanism for covering the needle after use and methods of assembly of the devices.

Abstract: A medicament delivery device includes a housing arranged to accommodate a medicament container, and a drive unit operably arranged to act on an accommodated medicament container for expelling a dose of medicament. The drive unit includes a plunger rod, a force element operably connected to the plunger rod, a connector arranged to releasably hold the plunger rod, an actuator element operably arranged to the connector, and a manually operable actuator arranged to act on the actuator element for releasing the connector when operated. A safety device is arranged to releasably hold the actuator element in a locking position with the connector, preventing unintended release of the plunger rod.

Abstract: The invention relates to a drive mechanism for a needle insertion arrangement, the drive mechanism comprising: an actuator, a rotatable drive pulley directly or indirectly coupled to the actuator, and a belt adapted to engage the drive pulley and adapted to be fixed to a needle retainer.

Abstract: A modular medical pump system provides separate pump units that may be pre-associated with flexible tubes. Multiple pump units may be installed in a controller that coordinates operation of the pump units for delivery of multiple medicaments to a patient. The pump units may carry drug information and the controller may hold patient information allowing drug delivery and interaction to be assessed by the controller.

Abstract: A medicament delivery device includes a housing having distal and proximal ends along a longitudinal axis. The housing is arranged to accommodate a medicament container and a delivery member connected to the container; a reloadable drive mechanism for acting on an accommodated container; a delivery member cover at the proximal end and slidable in relation to the housing along the axis; and a cover lock mechanism that includes a first lock member on an actuator movably arranged in relation to the housing and a second lock member on the cover. The first lock member engages the second lock member to block movement of the cover, and the actuator is movable in relation to the cover such that manually actuating the actuator generally transverse to the axis causes the first lock member to be moved out of engagement with the second lock member, thereby allowing the cover to be moved.

Abstract: A method of performing a medical procedure, includes providing a catheter including a first lumen in fluid communication with a first distal opening and a second lumen in fluid communication with a second distal opening, advancing a distal end of a first intra-catheter stiffener element through the first lumen and out of the first distal opening, coupling the first intra-catheter stiffener element to the catheter, advancing a distal end of a second intra-catheter stiffener element through the second lumen and out of the second distal opening, coupling the second intra-catheter stiffener element to the catheter, and advancing the catheter into a patient.

Abstract: A catheter having a secondary port that enables flushing a fluid from a portion of the catheter. The secondary port is disposed along the length of the catheter tube so as to be near an entry point of the catheter into a patient's body. A clamp is disposed adjacent to the secondary port on a side proximate to the patient's body. The secondary port and clamp enable flushing of a fluid from a portion of the catheter that is external to the patient's body and disposal of a clot- or obstruction-dissolving agent into the external portion of the catheter. Upon removal of the clot or obstruction, the secondary port and clamp enable removal of the dissolving agent and replenishing the fluid in the external portion of the catheter to resume provision of the fluid to the patient.

Abstract: A method and system are disclosed for driving a plunger in a drug reservoir. In some embodiments, a variable friction element interconnects between a pushing shaft and a wall of the reservoir. For example, rotation of a driving element in a first direction relative to the pushing shaft may advance the pushing shaft in the reservoir. The friction element may have increased friction resistance to rotation of the pushing shaft in the first direction in comparison to frictional resistance to advancing the pushing shaft. For example, the increased friction may result from wedging a radial element between the pushing shaft and the wall of the reservoir.

Abstract: A perimeter fill syringe is disclosed, wherein the syringe includes a solid core, allowing fluid to fill an area around the perimeter of the syringe barrel, enabling a wider diameter for the barrel thus increasing the visibility of the markings and ease of handling by a user.

Abstract: A handle component of a medical device is disclosed for delivering a material to an enclosed cavity or space. The handle component includes a self-contained mechanism for holding the material and for providing or releasing the material to the enclosed cavity. The handle component also includes a pressure relief valve in fluid communication with the mechanism and the enclosed cavity. The pressure relief valve is configured to indicate when delivery of the material to the enclosed cavity reaches a preselected or set pressure and to thereby assure precise filling of the enclosed cavity with the material.

Abstract: A medicament delivery device is provided having a power body having opposite proximal and distal ends, a plunger rod driver coaxial and movably arranged in relation to said power body, a plunger rod coaxial and movably arranged in relation to said plunger rod driver, a force spring element operably connected between the plunger rod and the power body The plunger rod driver has a first holding elements arranged to interact with second holding elements on the plunger rod and with the power body for releasably holding the plunger rod with the force spring element in an injection tensioned state.

Abstract: A drug coated balloon catheter has a balloon and a drug coating covering the surface of the balloon; the drug coating comprises an active drug and a carrier; the active drug is paclitaxel, rapamycin, a paclitaxel derivative or rapamycin derivative; the carrier comprises an organic acid salt and polyalcohol; a mass ratio of the active drug to the carrier in the drug coating is 0.2 to 100, and a mass ratio of the organic acid salt to the polyalcohol is (0.2 to 5):1. The organic acid salt and the polyalcohol in the drug coating jointly take effect to prevent the premature release of drugs before the balloon catheter is positioned at a target site, and to promote the drugs being quickly released from the surface of the balloon and absorbed by the target tissue, thus reducing drug loss during transmission, and also having a better drug transfer effect.

Abstract: Drive mechanism for a drug delivery device is disclosed. The drive mechanism includes an elongated housing extending in an axial direction. It includes a piston rod that operably engages with a piston of a cartridge to displace the piston in an axial distal direction. It includes a first dose indicating member that is rotatably supported on a longitudinal axis. It includes a second dose indicating member axially adjacent to the first dose indicating member and rotatably supported on the longitudinal axis. It includes a dose setting sleeve extending in an axial direction, rotatably engaged with the first dose indicating member and axially extending through the first dose indicating member to rotatably engage with the second dose indicating member.

Abstract: Cleaning systems and devices are provided for cleaning body-inserted tubes (e.g., endotracheal tubes, chest cleaning tubes). In one embodiment, a closed suction system includes a suction catheter having at least one deployable (e.g., inflatable) cleaning member at a distal portion of the suction catheter and at least one suction opening distal to the cleaning member. The closed suction system module may include a control unit at its proximal end adapted to facilitate operation in one of the following three operational states: i) a first operational state in which only the cleaning member is functional, ii) a second operational state in which only suction is functional, or iii) a third operational state in which neither suction nor the cleaning member is functional.

Abstract: The present invention provides an emergency supply valve to support the in situ administration of a drug to a subject in need thereof, comprising an infusion needle connected to a movable piston, wherein said piston is forwarded by infusion solution unable to pass the regular drug line due to kinking or obstruction thereof, a self-sealing membrane that is disrupted by the infusion needle when the piston is in a forward position, a connecting unit that connects the needle to the regular drug conduit when the needle is in a forward position, and a pressure sensitive mechanism that retracts the piston from the forward position when an increased pressure of the drug supply is normalized and its use for the treatment of subjects in need thereof.

Abstract: A method and system are disclosed for driving a plunger in a drug reservoir. In some embodiments, a variable friction element interconnects between a pushing shaft and a wall of the reservoir. For example, rotation of a driving element in a first direction relative to the pushing shaft may advance the pushing shaft in the reservoir. The friction element may have increased friction resistance to rotation of the pushing shaft in the first direction in comparison to frictional resistance to advancing the pushing shaft. For example, the increased friction may result from wedging a radial element between the pushing shaft and the wall of the reservoir.

Abstract: Drug delivery device adapted to receive a cartridge and including a housing, a front-loaded cartridge holder adapted to receive and hold a cartridge in a loaded position, and stop structure adapted to engage a proximal surface of a received cartridge The stop structure is actuatable between a receiving state in which the stop structure is positioned in a first axial position thereby defining how far proximally a received cartridge can be inserted, and an operational state in which the stop structure allows an inserted cartridge to be moved axially to a second more proximal position.

Abstract: An adaptor, system, and method for collecting for a breast pump. A breast milk bag has a hole adjacent an end margin. The bag can have a reclosable seal and a zone of weakness for separating a sealed portion from a header. An adaptor has inlet end and an outlet end and defines a flow passage. The inlet end is securable to the outlet of the breast pump so liquid therefrom can flow through the flow passage. A slot extends through the adaptor wall to at least partially define a retainer for extending through the hole to mount the bag on the adapter. In a method of use, the bag is secured to the adaptor using the retainer, filled with breast milk, sealed while secured to the adaptor, and the sealed portion of the bag can be removed by tearing the bag along the zone of weakness.