Abstract: A method of processing stillage by hydrothermally fractionating stillage to create unique product fractions, by heating the stillage to a temperature of 250 degrees F. to 350 degrees F., and recovering a stickwater fraction from the stillage. Stickwater, oil, biomass, bio-products, extracts, metabolites, and treated water obtained from the method above. A method of performing ethanol fermentation by hydrothermally fractionating stillage to create unique product fractions by heating the stillage to a temperature of 250 degrees F. to 350 degrees F., separating the stillage into a ProFat fraction and a stickwater fraction, and recovering oil from the ProFat fraction.

Abstract: Methods for controlling bleeding (e.g., enhancing coagulation and reducing fibrinolysis) in a subject are disclosed. The methods include selecting a subject in need of enhanced coagulation or reduced fibrinolysis, and administering to the subject a carbon monoxide releasing molecule (CORM). Examples of CORMs include tricarbonyldichloro-ruthenium (II) dimer, tricarbonylchloro-(glycinato)ruthenium (II), sodium boranocarbonate, dimanganese decacarbonyl, and iron pentacarbonyl. Further disclosed are compositions and methods for treating a subject in need of a blood product by administering to the subject a composition including a CORM and a blood product (e.g., cryoprecipitate or fresh frozen plasma).

Abstract: Disclosed herein are methods of detecting blood disorders, such as diabetes. In particular examples the method includes contacting a blood sample with an amine reagent, blocking an excess of the amine reagent with a blocking reagent, digesting the modified blood sample with trypsin to produce a digested blood sample containing a plurality of glycated N-terminal peptides and non-glycated N-terminal peptides, then analyzing the digested blood sample with MALDI MS. Also provided are reagents for use in such methods.

Abstract: A method and corresponding pharmaceutical composition to inhibit neuropathic pain by injecting intrathecally into a mammalian subject a neuropathic pain-inhibiting amount of a phosphatase falling within E.C. 3.1.3.x, more specifically a protein phosphatase falling within E.C. 3.1.3.16, and most specifically calcineurin.

Abstract: Method for extracting oils, proteins and fermentable sugars from vegetable material in an aqueous medium, includes: a) adding water to the vegetable material; b) adding an enzyme mixture containing at least one cellulase, at least one hemicellulase, and at least one pectinase, the ratio between the pectinase activity and the cellulase activity being at least 0.14, and the ratio between the pectinase activity and the hemicellulase activity being at least 7.10?3, the pectinase activity being less than 120 ?mol/min/mL; c) incubating the vegetable material and the enzyme mixture with stirring to release oils, proteins and fermentable sugars in the reaction medium; d) separating the reaction medium to obtain free oil, an aqueous phase containing proteins and fermentable sugars, and a solid phase; e) optionally separating and recycling an emulsion of free oil or aqueous phase, to the medium; f) separating the proteins and fermentable sugars from the aqueous phase.

Abstract: Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.

Abstract: A method for treating a patient with migraine headache includes administering to the patient a therapeutically effective amount of an invertebrate presynaptic neurotoxin in a pharmaceutically safe form. The administration includes extramuscular injection of the neurotoxin to emerging nerve points including foraminal sites for enabling neurotoxin access to concentrated nerve bundles at exit points of the foramina.

Abstract: The invention provides a method to prevent, inhibit or treat one or more neurological symptoms associated with a lysosomal storage disease in a mammal in need thereof, which includes intranasally administering to the mammal a composition comprising an effective amount of a lysosomal storage enzyme or a recombinant adeno-associated virus vector comprising an open reading frame encoding a lysosomal storage enzyme. Also provided are compositions and devices useful in the methods.

Abstract: The invention relates to a sensor comprising a sensing layer and a surface layer, wherein said surface layer comprises, a first region suitable for adherent growth of cells, and a second region, adjacent to said second layer, suitable for the attachment of proteins, wherein the first and second region are in contact with the sensing layer.

Abstract: The invention is composition comprising red blood cells in an aqueous suspension medium and one or more cis di-ahls; wherein more than 6 percent by weight of the hemoglobin in the red blood cells is S-Alc glycated hemoglobin. In another embodiment, the invention is a method comprising contacting red blood cells in a suspension medium having a concentration of S-Alc glycated hemoglobin of greater than 6 percent by weight of the hemoglobin in the red blood cells with a sufficient amount of one or more cis di-ahls such that the concentration of S-Alc glycated hemoglobin in resulting composition as measured by high pressure liquid chromatography, immunoassay and boronate affinity methods is consistent.

Abstract: By way of summary, the present invention meets some or all of the above needs by providing in a first aspect a method comprising contacting red blood cells in a suspension medium containing mannose under conditions such that the concentration of S-Alc glycated hemoglobin is increased to greater than about 6 percent by weight of the hemoglobin in the red blood cells. Preferably the suspension medium is an aqueous suspension medium. In preferred embodiments, the method is performed at about ambient temperature, 18° C. to about 23° C.

Abstract: A method and process is provided to help increase flow within the piping of a clinical vacuum system under low flow inlet conditions and to re-establish flow under zero flow inlet conditions, among other things. The method and process broadly uses the steps of isolating and accessing the piping of the clinical vacuum system, introducing an enzymatic solution to the piping, and then extracting the solution following exposure of the solution to the piping to remove complex organic materials from the piping. A portable collection canister can be used to measure the amount of enzymatic solution that is put into the piping and removed from the piping to ensure that the system is dry. The collection canister can be connected via hose to a zone valve box of the system or to a service valve of the system.

Abstract: A method for the production of alcohol and other bioproducts from power boiler woody biomass extract containing hemicelluloses, with or without combining extract from wood prior to Kraft cooking. The process is integrated with the host Kraft pulp mill plant process to minimize the heat loss from extracting hemicelluloses and the energy used in the process.

Abstract: The invention relates to a composition formulated for a topical application to the skin containing, as essential constituents, peroxide lipids that have a degree of peroxidation between 30 and 500 milliequivalents per kg of peroxide lipids and cod liver oil. This composition can be used as a medical device, in order to form a protective film on the skin, especially for the care of irritated skin and/or skin that has red spots and/or skin that has superficial lesions, and/or as an adjuvant in skin massaging operations. It is most particularly useful for the care and/or prevention of eschars.

Abstract: Methods are described for increasing the absorption of micronutrients such as vitamins and minerals by an organism's digestive system. Multiple competitions and multiple synergies between micronutrients are identified and micronutrient formulations are created so that synergistic micronutrients are included in the same formulation while competitive or interfering micronutrients are included in different formulations. At least two micronutrient formulations can be created with each formulation being ingested by the organism at a different time within a single twenty-four hour period or longer. By ingesting each micronutrient formulation at different and remote times, advantage is obtained from absorption synergies existing between some micronutrients while absorption interferences between competitive micronutrients are avoided or eliminated so as to increase the efficiency of absorption of micronutrients by the digestive system.