Patents Examined by Terra Gibbs
  • Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
    Patent number: 7034009
    Abstract: The present invention relates to nucleic acid molecules such as ribozymes, DNAzymes, and antisense which modulate the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor, such as flt-1 and KDR. Nucleic acid molecules and methods for the inhibition of angiogenesis and treatment of cancer and ocular diseases are provided, optionally in conjunction with other therapeutic agents.
    Type: Grant
    Filed: May 3, 2002
    Date of Patent: April 25, 2006
    Assignees: Sirna Therapeutics, Inc., Chiron Corporation
    Inventors: Pamela Pavco, James McSwiggen, Dan Stinchcomb, Jaime Escobedo
  • 88kDa tumorigenic growth factor and antagonists
    Patent number: 6670183
    Abstract: This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expression or action. Antagonists to an 88 KDa autocrine growth and tumorigenicity stimulator are provided which inhibit its expression or biological activity. The antagonists include antisense oligonucleotides and antibodies.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: December 30, 2003
    Assignee: A & G Pharmaceutical, Inc.
    Inventor: Ginette Serrero