Patents Examined by Thainan N Ton
  • Differentiation of human embryonic stem cells into pancreatic endocrine cells using thyroid hormone and/or alk5, an inhibitor of tgf-beta type 1 receptor
    Patent number: 10947511
    Abstract: The present invention provides methods to promote differentiation of pluripotent stem cells to pancreatic endoderm cells expressing PDX1, NKX6.1, and HB9. In particular, the methods encompass culturing Stage 4 to Stage 6 cells with a thyroid hormone (e.g. T3), an ALK5 inhibitor, or both.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: March 16, 2021
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Methods and compositions for growth of cells and embryonic tissue on a synthetic polymer matrix
    Patent number: 9487750
    Abstract: The present invention provides methods and compositions for establishing and maintaining growth of cells and embryonic tissue on a synthetic polymer matrix. For example, the present invention provides synthetic growth matrices for stem cells, gametes, mature differentiated cells, and embryonic tissue (e.g., blastomeres, embryos, and embryoid bodies). In certain embodiments, the cells are capable of going through multiple passages while remaining in an undifferentiated state as a result of the synthetic polymer matrix.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: November 8, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Gary D. Smith, Joerg Lahann, Himabindu Nandivada, Thomas Eyster, Luis Villa Diaz, Paul Krebsbach